Publications by authors named "Kevin D Bunker"

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The Selective Estrogen Receptor Degrader ZN-c5 Has Broad Anti-Tumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models.
Jianhui Ma, Sayee Hegde, Masha Sergeeva, Binita Chakraborty, Suzanne E Wardell, Kevin D Bunker

Mol Cancer Ther· December 2025

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Effects of a novel acetaminophen analog on cardiorespiratory compensatory responses and survival in a male rat model of traumatic hemorrhage.
Miryam M Pando, Kathy L Ryan, Mariam L Calderon, Cassandra M Rodriguez, Brian S Connor, Kevin D Bunker

Physiol Rep· November 2025

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Azenosertib Is a Potent and Selective WEE1 Kinase Inhibitor with Broad Antitumor Activity Across a Range of Solid Tumors.
Jianhui Ma, Wen Liu, Jiali Li, Daehwan Kim, Sangyub Kim, Kevin D Bunker

Mol Cancer Ther· August 2025

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Discovery of ZN-c5, an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) with Improved Pharmacokinetics.
Sayee G Hegde, Peter Q Huang, Kevin D Bunker, Chad D Hopkins, Deborah H Slee

J Med Chem· July 2025

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Discovery of an Orally Bioavailable and Brain Penetrant Selective Estrogen Receptor Degrader.
Guobao Zhang, Peter Q Huang, Kevin D Bunker, Sayee G Hegde, Jianhui Ma

J Med Chem· June 2025

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Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers.
Daehwan Kim, Heekyung Chung, Wen Liu, Kangjin Jeong, Tugba Y Ozmen, Kevin D Bunker

NPJ Precis Oncol· January 2025

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Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.
Peter Q Huang, Brant C Boren, Sayee G Hegde, Hui Liu, Aditya K Unni, Kevin D Bunker

J Med Chem· September 2021

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Evaluation of KP-1199: a novel acetaminophen analog for hemostatic function and antinociceptive effects.
Kristin M Reddoch-Cardenas, Bopaiah P Cheppudira, Thomas Garza, Chad D Hopkins, Kevin D Bunker

Transfusion· July 2021

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Acid-Induced Liberation of Polysubstituted Cyclopentadiene Ligands from Cyclopentadienyl Cobalt: A [2 + 2 + 1] Cycloaddition Route toward 1,2,4-Trisubstituted Cyclopentadienes.
Pengjin Qin, Ryan L Holland, Kevin D Bunker, Joseph M O'Connor, Kim K Baldridge

J Org Chem· November 2019

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Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
Qinhua Huang, Ted W Johnson, Simon Bailey, Alexei Brooun, Kevin D Bunker

J Med Chem· February 2014

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Scalable synthesis of 1-bicyclo[1.1.1]pentylamine via a hydrohydrazination reaction.
Kevin D Bunker, Neal W Sach, Qinhua Huang, Paul F Richardson

Org Lett· September 2011

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2-Chloro-4-(1H-pyrazol-1-yl)-5-(trifluoro-meth-yl)pyrimidine.
Kevin D Bunker, Curtis Moore, Cynthia L Palmer, Arnold L Rheingold, Alex Yanovsky

Acta Crystallogr Sect E Struct Rep Online· May 2010

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4-Chloro-7-hydr-oxy-6-methyl-1,7-naphthyridin-8(7H)-one.
Kevin D Bunker, Seiji Nukui, Arnold L Rheingold, Antonio Dipasquale, Alex Yanovsky

Acta Crystallogr Sect E Struct Rep Online· November 2009

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3-Amino-5-bromo-2-iodo-pyridine.
Kevin D Bunker, Neal W Sach, Seiji Nukui, Arnold L Rheingold, Alex Yanovsky

Acta Crystallogr Sect E Struct Rep Online· December 2008

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Reactions of a metallacyclobutene complex with alkenes.
Ryan L Holland, Kevin D Bunker, Christopher H Chen, Antonio G DiPasquale, Arnold L Rheingold

J Am Chem Soc· August 2008

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Sulfoxide carbon-sulfur bond activation.
Joseph M O'Connor, Kevin D Bunker, Arnold L Rheingold, Lev Zakharov

J Am Chem Soc· March 2005

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Ring-strain effects on the oxidation potential of enediynes and enediyne complexes.
Kim K Baldridge, Bernadette T Donovan-Merkert, Joseph M O'Connor, Linda I Lee, Adam Closson, Kevin D Bunker

Org Biomol Chem· March 2003

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