Publications by authors named "Kevin D Costa"

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Design and implementation of a Targeted HealthcaRe InnoVation & Entrepreneurship (THRIVE) fellowship program.
Ian C Odland, Joseph Borrello, Layla Fattah, Tyree D Williams, Kevin D Costa

PLoS One· September 2025

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Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2.
Chrystian Junqueira Alves, Theodore Hannah, Sita Sadia, Christy Kolsteeg, Angela Dixon, Paula Fernandes da Costa Franklin, Kevin D Costa

Nat Commun· January 2025

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Enhanced drug classification using machine learning with multiplexed cardiac contractility assays.
Reza Aghavali, Erin G Roberts, Yosuke K Kurokawa, Erica Mak, Martin Y C Chan, Kevin D Costa

Pharmacol Res· November 2024

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Regenerative potential of mouse neonatal intervertebral disc depends on collagen crosslink density.
Danielle N D'Erminio, Kaya A Adelzadeh, Ashley M Rosenberg, Robert J Wiener, Olivia M Torre, Kevin D Costa

iScience· October 2024

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Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia.
Valentina d'Escamard, Daniella Kadian-Dodov, Lijiang Ma, Sizhao Lu, Annette King, Kevin D Costa

Nat Cardiovasc Res· September 2024

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Generation and characterization of novel human induced pluripotent stem cell (iPSC) lines originating from five asymptomatic individuals carrying the PLN-R14del pathogenic variant and a non-carrier relative.
Valentina Balducci, Francesco Scardigli, Magdalena Harakalova, J Peter van Tintelen, Pieter A Doevendans, Kevin D Costa

Stem Cell Res· October 2023

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Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues.
Camille C van Neste, Karlo A Wiley, Serena W Chang, Joseph Borrello, Irene C Turnbull, Kevin D Costa

J Vis Exp· June 2023

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Rianú: Multi-tissue tracking software for increased throughput of engineered cardiac tissue screening.
Jack F Murphy, Kevin D Costa, Irene C Turnbull

Comput Methods Programs Biomed Update· May 2023

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Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues.
Shangli Cheng, David Brenière-Letuffe, Virpi Ahola, Andy O T Wong, Hoi Yee Keung, Kevin D Costa

iScience· April 2023

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Computational design of custom therapeutic cells to correct failing human cardiomyocytes.
Andrew Tieu, Katherine G Phillips, Kevin D Costa, Joshua Mayourian

Front Syst Biol· January 2023

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Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact.
Jaydev Dave, Nour Raad, Nishka Mittal, Lu Zhang, Anthony Fargnoli, Kevin D Costa

Cardiovasc Res· December 2022

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Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms.
Ben Ma, Elaina Melton, Robert Wiener, Ning Zhou, Wenqian Wu, Kevin D Costa

Hypertension· August 2022

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Generation of human induced pluripotent stem cell (iPSC) lines derived from five patients carrying the pathogenic phospholamban-R14del (PLN-R14del) variant and three non-carrier family members.
Nishka Mittal, Jaydev Dave, Magdalena Harakalova, J Peter van Tintelen, Folkert W Asselbergs, Kevin D Costa

Stem Cell Res· April 2022

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Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium.
Katherine G Phillips, Irene C Turnbull, Roger J Hajjar, Kevin D Costa, Joshua Mayourian

Front Physiol· January 2022

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Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues.
Andy On-Tik Wong, Bimal Gurung, Wing Sum Wong, Suet Yee Mak, Wan Wai Tse, Kevin D Costa

J Mol Cell Cardiol· April 2021

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High-resolution integrated piezoresistive sensors for microfluidic monitoring.
Yongxiao Zhou, Erik M Werner, Eugene Lee, Michael Chu, Thao Nguyen, Kevin D Costa

Lab Chip· January 2021

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Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation as Revealed by Optical Mapping of Action Potentials and Calcium Transients.
Andy On-Tik Wong, Nicodemus Wong, Lin Geng, Maggie Zi-Ying Chow, Eugene K Lee, Kevin D Costa

Front Physiol· March 2020

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Adult human cardiac stem cell supplementation effectively increases contractile function and maturation in human engineered cardiac tissues.
Jack F Murphy, Joshua Mayourian, Francesca Stillitano, Sadek Munawar, Kathleen M Broughton, Kevin D Costa

Stem Cell Res Ther· December 2019

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Sarco/endoplasmic reticulum Ca-ATPase is a more effective calcium remover than sodium-calcium exchanger in human embryonic stem cell-derived cardiomyocytes.
Sen Li, Anant Chopra, Wendy Keung, Camie W Y Chan, Kevin D Costa

Am J Physiol Heart Circ Physiol· November 2019

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Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses.
Wendy Keung, Patrick K W Chan, Peter C Backeris, Eugene K Lee, Nicodemus Wong, Kevin D Costa

Clin Pharmacol Ther· August 2019

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Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells.
Andy On-Tik Wong, Gabriel Wong, Michael Shen, Maggie Zi-Ying Chow, Wan Wai Tse, Kevin D Costa

Stem Cell Res Ther· July 2019

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Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues.
Maggie Zi-Ying Chow, Stephanie N Sadrian, Wendy Keung, Lin Geng, Lihuan Ren, Kevin D Costa

Sci Rep· May 2019

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An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity.
Joshua Mayourian, Eric A Sobie, Kevin D Costa

Methods Mol Biol· March 2019

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Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies.
Irene C Turnbull, Joshua Mayourian, Jack F Murphy, Francesca Stillitano, Delaine K Ceholski, Kevin D Costa

Methods Mol Biol· March 2019

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3D Printing a Mechanically-Tunable Acrylate Resin on a Commercial DLP-SLA Printer.
Joseph Borrello, Philip Nasser, James Iatridis, Kevin D Costa

Addit Manuf· October 2018

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