Publications by authors named "Kevin D McCarty"

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A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1.
Ziqi Zhu, Yoon-Mi Chung, Mohammad Alyamani, Yijing Dai, Kevin D McCarty

Nat Commun· December 2025

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A synthesis of 1β-hydroxytestosterone, a metabolite of xenobiotic human cytochrome P450 enzymes, beginning with a borylation of boldione.
Anna I Elizondo, Kevin D McCarty, Hadi D Arman, F Peter Guengerich, Francis K Yoshimoto

Org Biomol Chem· October 2025

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Mass Spectral Analysis of Sterols and Other Steroids in Different Ionization Modes: Sensitivity and Oxidation Artifacts.
Kevin D McCarty, F Peter Guengerich

J Am Soc Mass Spectrom· August 2025

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Cytochrome P450 and P450 11A1 retain Compound I (FeO) chemistry with electrophilic substrates poised for Compound 0 (FeO) reactions.
Kevin D McCarty, Yasuhiro Tateishi, F Peter Guengerich

J Biol Chem· July 2025

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Liver fatty acid binding protein FABP1 transfers substrates to cytochrome P450 4A11 for catalysis.
Kevin D McCarty, F Peter Guengerich

J Biol Chem· February 2025

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Roles of Ferric Peroxide Anion Intermediates (FeO , Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model.
Yasuhiro Tateishi, Kevin D McCarty, Martha V Martin, Francis K Yoshimoto, F Peter Guengerich

Angew Chem Int Ed Engl· August 2024

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Updates on Mechanisms of Cytochrome P450 Catalysis of Complex Steroid Oxidations.
F Peter Guengerich, Yasuhiro Tateishi, Kevin D McCarty, Francis K Yoshimoto

Int J Mol Sci· August 2024

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Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation.
Kevin D McCarty, Yasuhiro Tateishi, Tatiana Y Hargrove, Galina I Lepesheva, F Peter Guengerich

Angew Chem Int Ed Engl· February 2024

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Oxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4.
Yasuhiro Tateishi, Kevin D McCarty, Martha V Martin, F Peter Guengerich

ACS Catal· February 2024

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The multistep oxidation of cholesterol to pregnenolone by human cytochrome P450 11A1 is highly processive.
Kevin D McCarty, Lu Liu, Yasuhiro Tateishi, Hannah L Wapshott-Stehli, F Peter Guengerich

J Biol Chem· January 2024

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Steroid 17α-hydroxylase/17, 20-lyase (cytochrome P450 17A1).
F Peter Guengerich, Kevin D McCarty, Yasuhiro Tateishi, Lu Liu

Methods Enzymol· November 2023

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Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1.
Kevin D McCarty, Molly E Sullivan, Yasuhiro Tateishi, Tatiana Y Hargrove, Galina I Lepesheva

J Biol Chem· July 2023

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Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases.
Jeffrey Y Jian, Kevin D McCarty, Jo Ann W Byl, F Peter Guengerich, Keir C Neuman

Nucleic Acids Res· May 2023

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Kinetics of cytochrome P450 3A4 inhibition by heterocyclic drugs defines a general sequential multistep binding process.
F Peter Guengerich, Kevin D McCarty, Jesse G Chapman

J Biol Chem· August 2021

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Tight binding of cytochrome b to cytochrome P450 17A1 is a critical feature of stimulation of C21 steroid lyase activity and androgen synthesis.
Donghak Kim, Vitchan Kim, Kevin D McCarty, F Peter Guengerich

J Biol Chem· August 2021

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Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis.
F Peter Guengerich, Kevin D McCarty, Jesse G Chapman, Yasuhiro Tateishi

J Biol Chem· August 2021

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Tryptophan-75 Is a Low-Energy Channel-Gating Residue that Facilitates Substrate Egress/Access in Cytochrome P450 2D6.
Kevin D McCarty, Samuel A Ratliff, Kyle A Furge, Laura Lowe Furge

Drug Metab Dispos· March 2021

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