Publications by authors named "Kevin G Pinney"

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Targeting Tumor-Associated Hypoxia with Bioreductively Activatable Prodrug Conjugates Derived from Dihydronaphthalene, Benzosuberene, and Indole-based Inhibitors of Tubulin Polymerization.
Zhe Shi, Rajsekhar Guddneppanavar, Blake A Winn, Matthew T MacDonough, Clinton S George, Kevin G Pinney

RSC Med Chem· August 2025

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Benzosuberene and Tetracyclic Analogues as Colchicine Site Inhibitors of Tubulin Polymerization.
Jennifer M VanNatta, Graham J Carlson, Haichan Niu, Ruoli Bai, Hashini I Wanniarachchi, Kevin G Pinney

ACS Med Chem Lett· June 2025

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Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents.
Rebecca Vairin, Caleb Tamminga, Zhe Shi, Christian Borchardt, Jayaram Jambulapati, Kevin G Pinney

Bioorg Med Chem· February 2025

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Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers.
Jacob W Ford, Jennifer M VanNatta, Deboprosad Mondal, Chen-Ming Lin, Yuling Deng, Kevin G Pinney

Tetrahedron· February 2025

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Evaluating Therapeutic Efficacy of the Vascular Disrupting Agent OXi8007 Against Kidney Cancer in Mice.
Hashini I Wanniarachchi, Regan Schuetze, Yuling Deng, Khagendra B Hamal, Cyprian I Pavlich, Kevin G Pinney

Cancers (Basel)· February 2025

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Application of Chlorosulfonyl Isocyanate (CSI) in the Synthesis of Fused Tetracyclic Ketone Ring Systems.
Jennifer M VanNatta, Haichan Niu, Graham J Carlson, Kevin G Pinney

J Org Chem· November 2024

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Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization.
Wen Ren, Yuling Deng, Jacob D Ward, Rebecca Vairin, Ruoli Bai, Kevin G Pinney

Eur J Med Chem· January 2024

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Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues.
Wen Ren, Rebecca Vairin, Jacob D Ward, Ricardo Francis, Jenny VanNatta, Kevin G Pinney

Bioorg Med Chem· September 2023

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Synthesis of the Hypoxia-Inducible Factor-2 (HIF-2) Inhibitor, 3-[(1,2,3)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977, Belzutifan); Efficient Replication of Established Approaches.
Khagendra B Hamal, Cyprian I Pavlich, Graham J Carlson, Yu Ching Wong, Fangzhou Zhao, Kevin G Pinney

Tetrahedron Lett· September 2023

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Oxygen-Sensing Chemiluminescent Iridium(III) 1,2-Dioxetanes: Unusual Coordination and Activity.
Husain N Kagalwala, Lorena Bueno, Hashini Wanniarachchi, Daniel K Unruh, Khagendra B Hamal, Kevin G Pinney

Anal Sens· January 2023

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Demonstrating Tumor Vascular Disrupting Activity of the Small-Molecule Dihydronaphthalene Tubulin-Binding Agent OXi6196 as a Potential Therapeutic for Cancer Treatment.
Li Liu, Regan Schuetze, Jeni L Gerberich, Ramona Lopez, Samuel O Odutola, Kevin G Pinney

Cancers (Basel)· August 2022

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Imaging-Guided Evaluation of the Novel Small-Molecule Benzosuberene Tubulin-Binding Agent KGP265 as a Potential Therapeutic Agent for Cancer Treatment.
Yihang Guo, Honghong Wang, Jeni L Gerberich, Samuel O Odutola, Amanda K Charlton-Sevcik, Kevin G Pinney

Cancers (Basel)· September 2021

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Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors.
Li Liu, Devin O'Kelly, Regan Schuetze, Graham Carlson, Heling Zhou, Kevin G Pinney

Molecules· April 2021

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Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.
Blake A Winn, Laxman Devkota, Bunnarack Kuch, Matthew T MacDonough, Tracy E Strecker, Kevin G Pinney

J Nat Prod· April 2020

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Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.
Casey J Maguire, Graham J Carlson, Jacob W Ford, Tracy E Strecker, Ernest Hamel, Kevin G Pinney

Medchemcomm· August 2019

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Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization.
Haichan Niu, Tracy E Strecker, Jeni L Gerberich, James W Campbell, Debabrata Saha, Kevin G Pinney

J Med Chem· June 2019

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Efficient Synthetic Methodology for the Construction of Dihydronaphthalene and Benzosuberene Molecular Frameworks.
Deboprosad Mondal, Haichan Niu, Kevin G Pinney

Tetrahedron Lett· January 2019

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Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents.
Casey J Maguire, Zhi Chen, Vani P Mocharla, Madhavi Sriram, Tracy E Strecker, Kevin G Pinney

Medchemcomm· October 2018

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Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research.
Deboprosad Mondal, Jacob Ford, Kevin G Pinney

Tetrahedron Lett· October 2018

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Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L.
Erica N Parker, Samuel O Odutola, Yifan Wang, Tracy E Strecker, Rajeswari Mukherjee, Kevin G Pinney

Bioorg Med Chem Lett· March 2017

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Bioreductively activatable prodrug conjugates of phenstatin designed to target tumor hypoxia.
Blake A Winn, Zhe Shi, Graham J Carlson, Yifan Wang, Benson L Nguyen, Kevin G Pinney

Bioorg Med Chem Lett· February 2017

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Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.
Christine A Herdman, Tracy E Strecker, Rajendra P Tanpure, Zhi Chen, Alex Winters, Kevin G Pinney

Medchemcomm· December 2016

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Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
Laxman Devkota, Chen-Ming Lin, Tracy E Strecker, Yifan Wang, Justin K Tidmore, Kevin G Pinney

Bioorg Med Chem· March 2016

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Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization.
Christine A Herdman, Laxman Devkota, Chen-Ming Lin, Haichan Niu, Tracy E Strecker, Kevin G Pinney

Bioorg Med Chem· December 2015

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Mechanistic Considerations in the Synthesis of 2-Aryl-Indole Analogues under Bischler-Mohlau Conditions.
Matthew T MacDonough, Zhe Shi, Kevin G Pinney

Tetrahedron Lett· June 2015

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