Publications by authors named "Kevin Mellert"

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Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma.
Charles S Umbaugh, Marie Groth, Cihan Erkut, Kwang-Seok Lee, Joana Marinho, Kevin Mellert

Sci Adv· September 2025

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Complementary approaches define the metabolic features that accompany Richter syndrome transformation.
Giulia Omezzolli, Andrea Iannello, Francesco E Vallone, Lorenzo Brandimarte, Matilde Micillo, Kevin Mellert

Cell Mol Life Sci· April 2025

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Cucurbitacin B Exhibits Antitumor Effects on Chordoma Cells via Disruption of Brachyury.
Carolin Seeling, Johannes Neumahr, Fabian Häberle, André Lechel, Peter Möller, Kevin Mellert

Int J Mol Sci· April 2025

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Decreased apoptotic priming and loss of BCL-2 dependence are functional hallmarks of Richter's syndrome.
Antonella Rigo, Tiziana Vaisitti, Carlo Laudanna, Eleonora Terrabuio, Matilde Micillo, Kevin Mellert

Cell Death Dis· May 2024

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Impact of CDK Inhibitors on Expression in Chordoma Cell Lines Including the First Stable Cell Line of a High-Grade Chordoma.
Sarah Bette, Luisa Haase, Juliane Nell, Thomas Grieser, Alexandra von Baer, Kevin Mellert

Diagnostics (Basel)· May 2024

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[Giant cell tumor of bone-an update].
Felix Tschavoll, Gianluca Lutteri, Benedikt Leinauer, Kevin Mellert, Peter Möller

Pathologie (Heidelb)· December 2023

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Histomorphometric Analysis of 38 Giant Cell Tumors of Bone after Recurrence as Compared to Changes Following Denosumab Treatment.
Sophia Arndt, Wolfgang Hartmann, András Rókusz, Benedikt Leinauer, Alexandra von Baer, Kevin Mellert

Cancers (Basel)· August 2023

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Giant Cells of Various Lesions Are Characterised by Different Expression Patterns of HLA-Molecules and Molecules Involved in the Cell Cycle, Bone Metabolism, and Lineage Affiliation: An Immunohistochemical Study with a Review of the Literature.
Vivien Hild, Kevin Mellert, Peter Möller, Thomas F E Barth

Cancers (Basel)· July 2023

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Emergence of SARS-CoV-2 spike protein at the vaccination site.
Annika Beck, Hanna Dietenberger, Sebastian N Kunz, Kevin Mellert, Peter Möller

Immun Inflamm Dis· March 2023

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Prognostic Relevance and In Vitro Targeting of Concomitant PTEN and p16 Deficiency in Chordomas.
Carolin Seeling, Elena Mosca, Eva Mantel, Peter Möller, Thomas F E Barth, Kevin Mellert

Cancers (Basel)· March 2023

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Epigenetic lockdown of CDKN1A (p21) and CDKN2A (p16) characterises the neoplastic spindle cell component of giant cell tumours of bone.
Julian Giesche, Kevin Mellert, Sven Geißler, Sophia Arndt, Carolin Seeling

J Pathol· August 2022

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CARD9 Forms an Alternative CBM Complex in Richter Syndrome.
Julia Maier, André Lechel, Ralf Marienfeld, Thomas F E Barth, Peter Möller, Kevin Mellert

Cancers (Basel)· January 2022

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H3F3A-mutated giant cell tumour of bone without giant cells-clinical presentation, radiology and histology of three cases.
Benedikt Leinauer, Eduard Wolf, Mathias Werner, Daniel Baumhoer, Thomas Breining, Kevin Mellert

Histopathology· November 2021

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Ciprofloxacin enhances phototoxicity of 5-aminolevulinic acid mediated photodynamic treatment for chordoma cell lines.
Hanah Hadice Gull, Cihat Karadag, Brigitte Senger, Rüdiger V Sorg, Peter Möller, Kevin Mellert

Photodiagnosis Photodyn Ther· September 2021

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Molecular features and vulnerabilities of recurrent chordomas.
Carolin Seeling, André Lechel, Michael Svinarenko, Peter Möller, Thomas F E Barth, Kevin Mellert

J Exp Clin Cancer Res· July 2021

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Profiling of three H3F3A-mutated and denosumab-treated giant cell tumors of bone points to diverging pathways during progression and malignant transformation.
Marc Hasenfratz, Kevin Mellert, Ralf Marienfeld, Alexandra von Baer, Markus Schultheiss

Sci Rep· March 2021

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U-RT1 - A new model for Richter transformation.
Teresa Schmid, Julia Maier, Melanie Martin, Alpaslan Tasdogan, Eugen Tausch, Kevin Mellert

Neoplasia· January 2021

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U-DCS: characterization of the first permanent human dendritic sarcoma cell line.
Kevin Mellert, Julian Benckendorff, Frank Leithäuser, Katarzyna Zimmermann, Peter Wiegand

Sci Rep· December 2020

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Clostridial C3 Toxins Enter and Intoxicate Human Dendritic Cells.
Maximilian Fellermann, Christina Huchler, Lea Fechter, Tobias Kolb, Fanny Wondany, Kevin Mellert

Toxins (Basel)· September 2020

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The impact of SOCS1 mutations in diffuse large B-cell lymphoma.
Kevin Mellert, Melanie Martin, Jochen K Lennerz, Manuel Lüdeke, Annette M Staiger

Br J Haematol· December 2019

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Characterization of Three Novel H3F3A-mutated Giant Cell Tumor Cell Lines and Targeting of Their Wee1 Pathway.
Christoph Lübbehüsen, Julian Lüke, Carolin Seeling, Kevin Mellert, Ralf Marienfeld

Sci Rep· April 2019

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Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib.
Michael J Böhm, Ralf Marienfeld, Daniela Jäger, Kevin Mellert, Adrian von Witzleben

Sarcoma· January 2019

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H3F3A mutation in giant cell tumour of the bone is detected by immunohistochemistry using a monoclonal antibody against the G34W mutated site of the histone H3.3 variant.
Julian Lüke, Alexandra von Baer, Jordan Schreiber, Christoph Lübbehüsen, Thomas Breining, Kevin Mellert

Histopathology· July 2017

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HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.
Daniela Jäger, Thomas F E Barth, Silke Brüderlein, Angelika Scheuerle, Beate Rinner, Kevin Mellert

Sci Rep· May 2017

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Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway.
Adrian von Witzleben, Lukas T Goerttler, Ralf Marienfeld, Holger Barth, André Lechel, Kevin Mellert

Cancer Res· September 2015

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