Publications by authors named "Kevin Metcalf"

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Biologics developability data analysis using hierarchical clustering accelerates candidate lead selection, optimization, and preformulation screening.
Kevin James Metcalf, Galen Wo, Jan Paulo Zaragoza, Fahimeh Raoufi, Jeanne Baker

MAbs· December 2025

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Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.
Kayvon Pedram, D Judy Shon, Gabrielle S Tender, Natalia R Mantuano, Jason J Northey, Kevin J Metcalf

Nat Biotechnol· April 2024

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A machine learning strategy for the identification of key descriptors and prediction models for IgG monoclonal antibody developability properties.
Andrew B Waight, David Prihoda, Rojan Shrestha, Kevin Metcalf, Marc Bailly

MAbs· November 2023

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Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression.
Kevin James Metcalf, Mary-Kate Hayward, Eric Berens, Alastair J Ironside, Connor Stashko

Matrix Biol Plus· June 2022

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Leveraging microenvironmental synthetic lethalities to treat cancer.
Kevin J Metcalf, Alaa Alazzeh, Zena Werb, Valerie M Weaver

J Clin Invest· March 2021

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Synthetic Tuning of Domain Stoichiometry in Nanobody-Enzyme Megamolecules.
Kevin J Metcalf, Blaise R Kimmel, Daniel J Sykora, Justin A Modica, Kelly A Parker

Bioconjug Chem· January 2021

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Concepts of extracellular matrix remodelling in tumour progression and metastasis.
Juliane Winkler, Abisola Abisoye-Ogunniyan, Kevin J Metcalf, Zena Werb

Nat Commun· October 2020

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Role of Lipopolysaccharide in Protecting OmpT from Autoproteolysis during In Vitro Refolding.
Gaurav Sinsinbar, Sushanth Gudlur, Kevin J Metcalf, Milan Mrksich, Madhavan Nallani

Biomolecules· June 2020

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Long-Range Energy Transfer in Protein Megamolecules.
Elijah L Taylor, Kevin J Metcalf, Benedetta Carlotti, Cheng-Tsung Lai, Justin A Modica

J Am Chem Soc· November 2018

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Photoactivatable Reaction for Covalent Nanoscale Patterning of Multiple Proteins.
Shengwang Zhou, Kevin J Metcalf, Pradeep Bugga, Jennifer Grant, Milan Mrksich

ACS Appl Mater Interfaces· November 2018

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An estimate is worth about a thousand experiments: using order-of-magnitude estimates to identify cellular engineering targets.
Kevin James Metcalf, Marilyn F Slininger Lee, Christopher Matthew Jakobson, Danielle Tullman-Ercek

Microb Cell Fact· August 2018

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Use of Transcriptional Control to Increase Secretion of Heterologous Proteins in T3S Systems.
Kevin J Metcalf, Danielle Tullman-Ercek

Methods Mol Biol· January 2018

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Proteins adopt functionally active conformations after type III secretion.
Kevin James Metcalf, James Lea Bevington, Sandy Lisette Rosales, Lisa Ann Burdette, Elias Valdivia

Microb Cell Fact· December 2016

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Type III secretion as a generalizable strategy for the production of full-length biopolymer-forming proteins.
Anum Azam, Cheng Li, Kevin J Metcalf, Danielle Tullman-Ercek

Biotechnol Bioeng· November 2016

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Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor.
Michael L Burns, Thomas M Malott, Kevin J Metcalf, Arthya Puguh, Jonah R Chan

Biotechnol J· March 2016

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Using transcriptional control to increase titers of secreted heterologous proteins by the type III secretion system.
Kevin J Metcalf, Casey Finnerty, Anum Azam, Elias Valdivia, Danielle Tullman-Ercek

Appl Environ Microbiol· October 2014

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Directed evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae.
Michael L Burns, Thomas M Malott, Kevin J Metcalf, Benjamin J Hackel, Jonah R Chan

Appl Environ Microbiol· September 2014

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