Publications by authors named "Kevin Smart"

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Safety and Antitumor Activity of a Novel aCD25 Treg Depleter RG6292 as a Single Agent and in Combination with Atezolizumab in Patients with Solid Tumors.
Valentina Gambardella, Michael Ong, Maria E Rodriguez-Ruiz, Jean-Pascal Machiels, Miguel F Sanmamed, Kevin Smart

Cancer Res Commun· March 2025

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Development of a population pharmacokinetic model to characterize the pharmacokinetics of intrathecally administered tominersen in cerebrospinal fluid and plasma.
Yumi Yamamoto, Patricia Sanwald Ducray, Marcus Björnsson, Kevin Smart, Paul Grimsey

CPT Pharmacometrics Syst Pharmacol· September 2023

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PK/PD Mediated Dose Optimization of Emactuzumab, a CSF1R Inhibitor, in Patients With Advanced Solid Tumors and Diffuse-Type Tenosynovial Giant Cell Tumor.
Kevin Smart, Ann-Marie Bröske, Dominik Rüttinger, Claudia Mueller, Alex Phipps

Clin Pharmacol Ther· September 2020

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First-in-Human Phase I Study of Single-agent Vanucizumab, A First-in-Class Bispecific Anti-Angiopoietin-2/Anti-VEGF-A Antibody, in Adult Patients with Advanced Solid Tumors.
Manuel Hidalgo, Maria Martinez-Garcia, Christophe Le Tourneau, Christophe Massard, Elena Garralda, Kevin Smart

Clin Cancer Res· April 2018

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The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects.
Bruce E Miller, Sunil Mistry, Kevin Smart, Paul Connolly, Donald C Carpenter

BMC Pharmacol Toxicol· June 2015

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The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers.
Bruce E Miller, Kevin Smart, Sunil Mistry, Claire L Ambery, Jackie C Bloomer

Eur J Drug Metab Pharmacokinet· September 2014

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Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: a double-blind randomized controlled trial.
Saifudin Khalid, Robert Murdoch, Amy Newlands, Kevin Smart, Angela Kelsall

J Allergy Clin Immunol· July 2014

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Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist.
Carlijn Holland, Cornelis van Drunen, Jane Denyer, Kevin Smart, Christine Segboer

Br J Clin Pharmacol· May 2014

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TRPV1 inhibition does not prevent cold dry air-elicited symptoms in non-allergic rhinitis.
Robert D Murdoch, Philippe Bareille, Jane Denyer, Amy Newlands, Jane Bentley, Kevin Smart

Int J Clin Pharmacol Ther· April 2014

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The effects of a TRPV1 antagonist, SB-705498, in the treatment of seasonal allergic rhinitis.
Philippe Bareille, Robert D Murdoch, Jane Denyer, Jane Bentley, Kevin Smart

Int J Clin Pharmacol Ther· July 2013

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Efficacy, safety and tolerability of GSK2190915, a 5-lipoxygenase activating protein inhibitor, in adults and adolescents with persistent asthma: a randomised dose-ranging study.
Richard M A Follows, Neil G Snowise, Shu-Yen Ho, Claire L Ambery, Kevin Smart

Respir Res· May 2013

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Hyperammonaemia reduces intracellular 22Na (sodium) ion and extracellular 86Rb ion concentrations in the blood-brain barrier of the rat.
Barry Alexander, Kevin A Smart, Malcolm B Segal, Jane E Preston

Metab Brain Dis· March 2005

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