Publications by authors named "Kevin Tharp"

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Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis.
Preeti Yadav, Javier Gómez Ortega, Prerna Dabral, Whitney Tamaki, Charles Chien, Kevin M Tharp

J Clin Invest· November 2025

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The biophysical mechanism of mitochondrial pearling.
Gabriel Sturm, Kayley Hake, Austin E Y T Lefebvre, Caleb J Rux, Daria Ivanova, Kevin M Tharp

Mol Biol Cell· November 2025

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DeepTarget predicts anti-cancer mechanisms of action of small molecules by integrating drug and genetic screens.
Sanju Sinha, Neelam Sinha, Marlenne Perales, Adi Tarrab, Trinh Nguyen, Kevin Tharp

NPJ Precis Oncol· November 2025

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Ovarian Tumor FAK Inhibition Releases Omega-3 Fatty Acids Stimulating GATA6 Peritoneal Macrophage CXCL13 Production Enhancing Immunotherapy.
Xiao Lei Chen, Kevin M Tharp, Marjaana Ojalill, Duygu Ozmadenci, Antonia Boyer

bioRxiv· September 2025

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Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis.
Preeti Yadav, Javier Gómez Ortega, Prerna Dabral, Whitney Tamaki, Charles Chien, Kevin M Tharp

bioRxiv· July 2025

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Have plastic culture models prevented the discovery of effective cancer therapeutics?
Kevin M Tharp

Br J Pharmacol· November 2024

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A mitochondrial redox switch licenses the onset of morphogenesis in animals.
Updip Kahlon, Francesco Dalla Ricca, Saraswathi J Pillai, Marine Olivetta, Kevin M Tharp

bioRxiv· October 2024

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Growth on stiffer substrates impacts animal health and longevity in C. elegans.
Maria Oorloff, Adam Hruby, Maxim Averbukh, Athena Alcala, Naibedya Dutta, Kevin M Tharp

PLoS One· September 2024

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Tumor-associated macrophages restrict CD8 T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.
Kevin M Tharp, Kelly Kersten, Ori Maller, Greg A Timblin, Connor Stashko

Nat Cancer· July 2024

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Patient Navigation Plus Tailored Digital Video Disc Increases Colorectal Cancer Screening Among Low-Income and Minority Patients Who Did Not Attend a Scheduled Screening Colonoscopy: A Randomized Trial.
Susan M Rawl, Susan M Perkins, Yan Tong, Mira L Katz, Lisa Carter-Bawa, Kevin Tharp

Ann Behav Med· April 2024

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Mechanical stress through growth on stiffer substrates impacts animal health and longevity in .
Maria Oorloff, Adam Hruby, Maxim Averbukh, Athena Alcala, Naibedya Dutta, Kevin M Tharp

bioRxiv· April 2024

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The microenvironment dictates glycocalyx construction and immune surveillance.
Kevin M Tharp, Sangwoo Park, Greg A Timblin, Alicia L Richards, Jordan A Berg

Res Sq· August 2023

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Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.
Kelly Kersten, Ran You, Sophia Liang, Kevin M Tharp, Joshua Pollack

Cell Rep· June 2023

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SARS-CoV-2 interacts with the Clic-like chloride channel-1 () and triggers an unfolded protein response.
Hannah N Gruner, Yaohuan Zhang, Kaavian Shariati, Nicholas Yiv, Zicheng Hu, Kevin Tharp

PeerJ· April 2023

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Process Evaluation of a Mailed Interactive Educational DVD in a Comparative Effectiveness Trial to Promote Colorectal Cancer Screening.
Mira L Katz, Brent Emerson, Victoria L Champion, Peter H Schwartz, Thomas F Imperiale, Kevin Tharp

Health Promot Pract· September 2022

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Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.
Ian D Ferguson, Yu-Hsiu T Lin, Christine Lam, Hao Shao, Kevin M Tharp

Cell Chem Biol· August 2022

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Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization.
Erica A Moehle, Ryo Higuchi-Sanabria, C Kimberly Tsui, Stefan Homentcovschi, Kevin M Tharp

Sci Adv· October 2021

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Adhesion-mediated mechanosignaling forces mitohormesis.
Kevin M Tharp, Ryo Higuchi-Sanabria, Greg A Timblin, Breanna Ford, Carlos Garzon-Coral

Cell Metab· July 2021

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Mitohormesis reprogrammes macrophage metabolism to enforce tolerance.
Greg A Timblin, Kevin M Tharp, Breanna Ford, Janet M Winchester, Jerome Wang

Nat Metab· May 2021

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Transcriptomic analysis reveals that BMP4 sensitizes glioblastoma tumor-initiating cells to mechanical cues.
Jasmine H Hughes, Jeanette M Ewy, Joseph Chen, Sophie Y Wong, Kevin M Tharp

Matrix Biol· January 2020

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Modeling Tissue Polarity in Context.
Kevin M Tharp, Valerie M Weaver

J Mol Biol· September 2018

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Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues.
Kevin M Tharp, Michael S Kang, Greg A Timblin, Jon Dempersmier, Garret E Dempsey

Cell Metab· March 2018

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The Sense of Smell Impacts Metabolic Health and Obesity.
Celine E Riera, Eva Tsaousidou, Jonathan Halloran, Patricia Follett, Oliver Hahn, Kevin Tharp

Cell Metab· July 2017

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WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue.
Peter Loskill, Thiagarajan Sezhian, Kevin M Tharp, Felipe T Lee-Montiel, Shaheen Jeeawoody

Lab Chip· May 2017

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Amplification of Adipogenic Commitment by VSTM2A.
Blandine Secco, Étienne Camiré, Marc-Antoine Brière, Alexandre Caron, Armande Billong, Kevin M Tharp

Cell Rep· January 2017

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