Publications by authors named "Kevin W Hallgren"

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Cellular and biochemical approaches to define GGCX carboxylation of vitamin K-dependent proteins.
Kathleen L Berkner, Kevin W Hallgren, Mark A Rishavy, Kurt W Runge

Methods Enzymol· November 2024

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GGCX mutants that impair hemostasis reveal the importance of processivity and full carboxylation to VKD protein function.
Mark A Rishavy, Kevin W Hallgren, Lee A Wilson, James M Hiznay, Kurt W Runge

Blood· October 2022

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Exon 2 skipping eliminates γ-glutamyl carboxylase activity, indicating a partial splicing defect in a patient with vitamin K clotting factor deficiency.
Mark A Rishavy, Kevin W Hallgren, Haitao Zhang, Kurt W Runge, Kathleen L Berkner

J Thromb Haemost· July 2019

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Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase.
Mark A Rishavy, Kevin W Hallgren, Lee Wilson, Savita Singh, Kurt W Runge

Blood· June 2018

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The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation.
Mark A Rishavy, Kevin W Hallgren, Lee A Wilson, Aisulu Usubalieva, Kurt W Runge

J Biol Chem· November 2013

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The vitamin K-dependent carboxylase generates γ-carboxylated glutamates by using CO2 to facilitate glutamate deprotonation in a concerted mechanism that drives catalysis.
Mark A Rishavy, Kevin W Hallgren, Kathleen L Berkner

J Biol Chem· December 2011

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Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation.
Mark A Rishavy, Aisulu Usubalieva, Kevin W Hallgren, Kathleen L Berkner

J Biol Chem· March 2011

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Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes.
Qiaoli Li, Dorothy K Grange, Nicole L Armstrong, Alison J Whelan, Maria Y Hurley, Kevin W Hallgren

J Invest Dermatol· March 2009

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Brønsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation.
Mark A Rishavy, Kevin W Hallgren, Anna V Yakubenko, Rebecca L Shtofman, Kurt W Runge

Biochemistry· November 2006

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Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiency.
Dhouha Darghouth, Kevin W Hallgren, Rebecca L Shtofman, Amel Mrad, Youssef Gharbi

Blood· September 2006

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r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step.
Kevin W Hallgren, Wen Qian, Anna V Yakubenko, Kurt W Runge, Kathleen L Berkner

Biochemistry· May 2006

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The vitamin K-dependent carboxylase has been acquired by Leptospira pathogens and shows altered activity that suggests a role other than protein carboxylation.
Mark A Rishavy, Kevin W Hallgren, Anna V Yakubenko, Richard L Zuerner, Kurt W Runge

J Biol Chem· October 2005

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A new model for vitamin K-dependent carboxylation: the catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine.
Mark A Rishavy, B Nirmala Pudota, Kevin W Hallgren, Wen Qian, Anna V Yakubenko

Proc Natl Acad Sci U S A· September 2004

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Carboxylase overexpression effects full carboxylation but poor release and secretion of factor IX: implications for the release of vitamin K-dependent proteins.
Kevin W Hallgren, Eric L Hommema, Beth A McNally, Kathleen L Berkner

Biochemistry· December 2002

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