Publications by authors named "Kim Beyer"

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Identification and characterization of binders to a cryptic and functional pocket in KRAS.
Kim S Beyer, Jessica Klein, Stéphanie Katz, Patrick Welker, Mylene Lanter

Nat Commun· December 2025

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Author Correction: Targeting the SHOC2-RAS interaction in RAS-mutant cancers.
Zachary J Hauseman, Frédéric Stauffer, Kim S Beyer, Sandra Mollé, Elena Cavicchioli

Nature· July 2025

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Promise and Challenge of β-Lactone Electrophiles to Target Aspartate 12 of Mutant KRAS.
Balázs Budai, Andrea Vaupel, Callum J Dickson, Kim S Beyer, Daniel A Guthy

J Med Chem· July 2025

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Targeting the SHOC2-RAS interaction in RAS-mutant cancers.
Zachary J Hauseman, Frédéric Stauffer, Kim S Beyer, Sandra Mollé, Elena Cavicchioli

Nature· June 2025

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Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras.
Charles W Parry, Francesca Pellicano, Alexander W Schüttelkopf, Kim S Beyer, Justin Bower

J Med Chem· May 2025

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Dynamic conformational equilibria in the active states of KRAS and NRAS.
Enrico Rennella, Chrystèle Henry, Callum J Dickson, Florian Georgescauld, Thomas E Wales, Kim S Beyer

RSC Chem Biol· January 2025

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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS for the Treatment of Solid Tumors.
Edwige Lorthiois, Marc Gerspacher, Kim S Beyer, Andrea Vaupel, Catherine Leblanc

J Med Chem· December 2022

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Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Zachary J Hauseman, Michelle Fodor, Anxhela Dhembi, Jessica Viscomi, David Egli, Kim S Beyer

Nature· September 2022

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Andreas Weiss, Edwige Lorthiois, Louise Barys, Kim S Beyer, Claudio Bomio-Confaglia

Cancer Discov· June 2022

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New Potent DOT1L Inhibitors for Evaluation in Mouse.
Frédéric Stauffer, Andreas Weiss, Clemens Scheufler, Henrik Möbitz, Christian Ragot, Kim S Beyer

ACS Med Chem Lett· December 2019

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Influence of Biodentine® - A Dentine Substitute - On Collagen Type I Synthesis in Pulp Fibroblasts In Vitro.
Frangis Nikfarjam, Kim Beyer, Anke König, Matthias Hofmann, Manuel Butting

PLoS One· July 2017

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Photodynamic Treatment of Oral Squamous Cell Carcinoma Cells with Low Curcumin Concentrations.
Kim Beyer, Frangis Nikfarjam, Manuel Butting, Markus Meissner, Anke König

J Cancer· May 2017

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Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.
Henrik Möbitz, Rainer Machauer, Philipp Holzer, Andrea Vaupel, Frédéric Stauffer, Kim S Beyer

ACS Med Chem Lett· March 2017

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Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket.
Clemens Scheufler, Henrik Möbitz, Christoph Gaul, Christian Ragot, Céline Be, Kim S Beyer

ACS Med Chem Lett· August 2016

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Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach.
Chao Chen, Hugh Zhu, Frédéric Stauffer, Giorgio Caravatti, Susanne Vollmer, Kim S Beyer

ACS Med Chem Lett· August 2016

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A comparative study of fragment screening methods on the p38α kinase: new methods, new insights.
Scott J Pollack, Kim S Beyer, Christopher Lock, Ilka Müller, David Sheppard

J Comput Aided Mol Des· July 2011

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FARP2, HDLBP and PASK are downregulated in a patient with autism and 2q37.3 deletion syndrome.
Bärbel Felder, Bernhard Radlwimmer, Axel Benner, Antoaneta Mincheva, Grischa Tödt, Kim S Beyer

Am J Med Genet A· May 2009

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Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation.
Kim S Beyer, Roberta L Beauchamp, Ming-Fen Lee, James F Gusella, Anders M Näär

J Biol Chem· November 2007

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Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.
Ming-Fen Lee, Roberta L Beauchamp, Kim S Beyer, James F Gusella, Vijaya Ramesh

Biochem Biophys Res Commun· September 2006

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Mutation screening and association analysis of six candidate genes for autism on chromosome 7q.
Elena Bonora, Janine A Lamb, Gabrielle Barnby, Nuala Sykes, Thomas Moberly, Kim S Beyer

Eur J Hum Genet· February 2005

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Mutation analysis of the coding sequence of the MECP2 gene in infantile autism.
Kim S Beyer, Francesca Blasi, Elena Bacchelli, Sabine M Klauck, Elena Maestrini

Hum Genet· October 2002

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A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome.
Sabine M Klauck, Susan Lindsay, Kim S Beyer, Miranda Splitt, John Burn

Am J Hum Genet· April 2002

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Association studies of the HOPA dodecamer duplication variant in different subtypes of autism.
Kim S Beyer, Sabine M Klauck, Axel Benner, Fritz Poustka, Annemarie Poustka

Am J Med Genet· January 2002

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