Publications by authors named "Kim Brouwer"

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Evaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters.
Mattie Hartauer, Henry Ho, Meimei Wan, William A Murphy, Jacqueline B Tiley, Kim L R Brouwer

Cell Mol Life Sci· December 2025

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Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability-Limited Multicompartment Liver Model.
William A Murphy, Noora Sjöstedt, Mailys De Sousa Mendes, Mattie Hartauer, Kim L R Brouwer

CPT Pharmacometrics Syst Pharmacol· November 2025

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Comparison of Metformin PBPK Models Incorporating Placental Transfer to Predict Fetal and Maternal Exposure.
Jacqueline B Tiley, Mattie E Hartauer, Tajhia L Whigham, Maïlys De Sousa Mendes, Kim L R Brouwer

CPT Pharmacometrics Syst Pharmacol· November 2025

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Understanding Coproporphyrins and Their Disposition: Coproporphyrinuria is Common, of Diverse Cause, and Rarely Indicates Porphyria.
Herbert L Bonkovsky, Christopher D Ma, Manuela Araque, Jacqueline B Tiley, Kim L R Brouwer

Am J Med· September 2025

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Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity.
Mohammad Anwar Hossain, Abigail K Mayo, Anirban Ghoshal, Sharon Taft-Benz, Elizabeth Anderson, Kim L R Brouwer

J Med Chem· May 2025

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Altered bile acid and coproporphyrin-I disposition in patients with autosomal dominant polycystic kidney disease.
Jacqueline B Tiley, James J Beaudoin, Vimal K Derebail, William A Murphy, Christine C Park, Kim L R Brouwer

Br J Clin Pharmacol· February 2025

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Correction to "Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo".
Feifei Yang, Yusra Medik, Liantao Li, Xi Tian, Dong Fu, Kim L R Brouwer

Small· February 2025

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Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with Anti-alphaviral Activity.
Mohammad Anwar Hossain, Abigail K Mayo, Anirban Ghoshal, Sharon A Taft-Benz, Elizabeth J Anderson, Kim L R Brouwer

bioRxiv· January 2025

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Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework.
Mattie Hartauer, William A Murphy, Kim L R Brouwer, Roz Southall, Sibylle Neuhoff

CPT Pharmacometrics Syst Pharmacol· September 2024

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Effects of PFAS on human liver transporters: implications for health outcomes.
Ena Vujic, Stephen S Ferguson, Kim L R Brouwer

Toxicol Sci· August 2024

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Membrane transporters in drug development and as determinants of precision medicine.
Aleksandra Galetin, Kim L R Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt

Nat Rev Drug Discov· April 2024

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Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD).
Jeffry Adiwidjaja, Jessica Spires, Kim L R Brouwer

Pharm Res· March 2024

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Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD.
William A Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D Guy, Kim L R Brouwer

Hepatol Commun· March 2024

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Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers.
Angela Jeong, Catherine M Pastor, Kim L R Brouwer

Pharm Res· November 2023

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Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity.
Chitra Saran, Kim L R Brouwer

Toxicol Pathol· October 2023

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Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function .
Chitra Saran, Henry Ho, Paavo Honkakoski, Kim L R Brouwer

Front Pharmacol· March 2023

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Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH).
William A Murphy, Jeffry Adiwidjaja, Noora Sjöstedt, Kyunghee Yang, James J Beaudoin, Kim L R Brouwer

Clin Pharmacol Ther· February 2023

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Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences.
Jacqueline E McLaughlin, Rebekah L Layton, Paul B Watkins, Robert A Nicholas, Kim L R Brouwer

PLoS One· December 2022

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Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium.
Kim L R Brouwer, Raymond Evers, Elizabeth Hayden, Shuiying Hu, Cindy Yanfei Li

Clin Pharmacol Ther· September 2022

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Clinical Relevance of Hepatic and Renal P-gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective.
Kunal S Taskar, Xinning Yang, Sibylle Neuhoff, Mitesh Patel, Kenta Yoshida, Kim L R Brouwer

Clin Pharmacol Ther· September 2022

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A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity.
Chitra Saran, Dong Fu, Henry Ho, Abigail Klein, John K Fallon, Kim L R Brouwer

Sci Rep· August 2022

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Lipidomics profiles in hepatocytes from nonalcoholic steatohepatitis patients differ markedly from in vitro-induced steatotic hepatocytes.
Thomas Kralj, Raju Khatri, Kenneth R Brouwer, Kim L R Brouwer, Darren J Creek

FEBS Lett· June 2022

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Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors.
Chitra Saran, Louise Sundqvist, Henry Ho, Jonna Niskanen, Paavo Honkakoski, Kim L R Brouwer

J Pharmacol Exp Ther· February 2022

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New Pharmacokinetic Parameters of Imaging Substrates Quantified from Rat Liver Compartments.
Catherine M Pastor, Kim L R Brouwer

Drug Metab Dispos· January 2022

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Identification of Key Amino Acids that Impact Organic Solute Transporter / (OSTα/β).
William A Murphy, James J Beaudoin, Tuomo Laitinen, Noora Sjöstedt, Melina M Malinen, Kim L R Brouwer

Mol Pharmacol· December 2021

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