Publications by authors named "Kenneth R Brouwer"

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Transporters and Toxicity: Insights From the International Transporter Consortium Workshop 4.
Michael J Hafey, Lauren M Aleksunes, Christy C Bridges, Kenneth R Brouwer, Huan-Chieh Chien

Clin Pharmacol Ther· September 2022

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Lipidomics profiles in hepatocytes from nonalcoholic steatohepatitis patients differ markedly from in vitro-induced steatotic hepatocytes.
Thomas Kralj, Raju Khatri, Kenneth R Brouwer, Kim L R Brouwer, Darren J Creek

FEBS Lett· June 2022

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Probe Cocktail to Assess Transporter Function in Sandwich-Cultured Human Hepatocytes.
Cen Guo, Kenneth R Brouwer, Paul W Stewart, Caroline Mosley, Kim L R Brouwer

J Pharm Pharm Sci· August 2020

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The C-DILI™ Assay: An Integrated In Vitro Approach to Predict Cholestatic Hepatotoxicity.
Jonathan P Jackson, Kenneth R Brouwer

Methods Mol Biol· August 2019

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Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters.
Tristan M Sissung, Phoebe A Huang, Ralph J Hauke, Edel M McCrea, Cody J Peer, Kenneth R Brouwer

Mol Pharmacol· August 2019

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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective.
J Gerry Kenna, Kunal S Taskar, Christina Battista, David L Bourdet, Kim L R Brouwer, Kenneth R Brouwer

Clin Pharmacol Ther· November 2018

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Farnesoid X Receptor Agonists Obeticholic Acid and Chenodeoxycholic Acid Increase Bile Acid Efflux in Sandwich-Cultured Human Hepatocytes: Functional Evidence and Mechanisms.
Cen Guo, Carl LaCerte, Jeffrey E Edwards, Kenneth R Brouwer, Kim L R Brouwer

J Pharmacol Exp Ther· May 2018

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Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa).
Merrie Mosedale, Donald Button, Jonathan P Jackson, Kimberly M Freeman, Kenneth R Brouwer

Toxicol Sci· February 2018

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Comparative potency of obeticholic acid and natural bile acids on FXR in hepatic and intestinal in vitro cell models.
Yuanyuan Zhang, Carl LaCerte, Sanjay Kansra, Jonathan P Jackson, Kenneth R Brouwer

Pharmacol Res Perspect· December 2017

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Prediction of Hepatic Efflux Transporter-Mediated Drug Interactions: When Is it Optimal to Measure Intracellular Unbound Fraction of Inhibitors?
Cen Guo, Kyunghee Yang, Mingxiang Liao, Cindy Q Xia, Kenneth R Brouwer, Kim L R Brouwer

J Pharm Sci· September 2017

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Prediction of Clinically Relevant Herb-Drug Clearance Interactions Using Sandwich-Cultured Human Hepatocytes: Case Study.
Jonathan P Jackson, Kimberly M Freeman, Weslyn W Friley, Ashley G Herman, Christopher B Black, Kenneth R Brouwer

Drug Metab Dispos· September 2017

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Obeticholic acid, a selective farnesoid X receptor agonist, regulates bile acid homeostasis in sandwich-cultured human hepatocytes.
Yuanyuan Zhang, Jonathan P Jackson, Robert L St Claire, Kimberly Freeman, Kenneth R Brouwer

Pharmacol Res Perspect· August 2017

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Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation.
Cen Guo, Kyunghee Yang, Kenneth R Brouwer, Robert L St Claire, Kim L R Brouwer

J Pharmacol Exp Ther· August 2016

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Hepatocellular Disposition and Transporter Interactions with Tolvaptan and Metabolites in Sandwich-Cultured Human Hepatocytes.
Yang Lu, Jason R Slizgi, Kenneth R Brouwer, Robert L St Claire, Kimberly M Freeman, Kim L Brouwer

Drug Metab Dispos· June 2016

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Assessing Natural Product-Drug Interactions: An End-to-End Safety Framework.
Amy L Roe, Mary F Paine, Bill J Gurley, Kenneth R Brouwer, Scott Jordan

Regul Toxicol Pharmacol· April 2016

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Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?
Jason R Slizgi, Yang Lu, Kenneth R Brouwer, Robert L St Claire, Kimberly M Freeman, Kim L R Brouwer

Toxicol Sci· January 2016

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Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.
Eve-Irene Lepist, Hunter Gillies, William Smith, Jia Hao, Cassandra Hubert, Kenneth R Brouwer

PLoS One· September 2014

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Automated applications of sandwich-cultured hepatocytes in the evaluation of hepatic drug transport.
Cassandra H Perry, William R Smith, Robert L St Claire, Kenneth R Brouwer

J Biomol Screen· April 2011

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An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes.
John H Ansede, William R Smith, Cassandra H Perry, Robert L St Claire, Kenneth R Brouwer

Drug Metab Dispos· February 2010

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Characterization of sandwich-cultured hepatocytes as an in vitro model to assess the hepatobiliary disposition of copper.
John H Ansede, Matthew R Wright, Robert L St Claire, Robert W Hart, Holly A Gefroh, Kenneth R Brouwer

Drug Metab Dispos· May 2009

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Effect of albumin on the biliary clearance of compounds in sandwich-cultured rat hepatocytes.
Kristina K Wolf, Kenneth R Brouwer, Gary M Pollack, Kim L R Brouwer

Drug Metab Dispos· October 2008

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GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats.
Jeffrey E Edwards, Kenneth R Brouwer, Patrick J McNamara

Antimicrob Agents Chemother· July 2002

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