Publications by authors named "Merrie Mosedale"

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Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities.
Sean Hammond, Xiaoli Meng, Jane Barber, Merrie Mosedale, Amy Chadwick

Toxicol Sci· January 2025

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Activation of tolvaptan-responsive T-cell clones with the structurally-related mozavaptan.
Sean Hammond, Xiaoli Meng, Merrie Mosedale, Dean J Naisbitt

Toxicol Lett· January 2023

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Human-relevant mechanisms and risk factors for TAK-875-Induced liver injury identified via a gene pathway-based approach in Collaborative Cross mice.
Merrie Mosedale, Yanwei Cai, J Scott Eaddy, Patrick J Kirby, Francis S Wolenski

Toxicology· September 2021

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Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury.
Manisha Nautiyal, Rani J Qasem, John K Fallon, Kristina K Wolf, Jingli Liu, Merrie Mosedale

Toxicol In Vitro· February 2021

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Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression.
Raju Khatri, Natasha Kulick, Rebecca J B Rementer, John K Fallon, Craig Sykes, Merrie Mosedale

J Pharm Sci· January 2021

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Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite.
Sean Hammond, Andrew Gibson, Kanoot Jaruthamsophon, Sharin Roth, Merrie Mosedale

Toxicol Sci· January 2021

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Differential Detergent Fractionation of Membrane Protein From Small Samples of Hepatocytes and Liver Tissue for Quantitative Proteomic Analysis of Drug Metabolizing Enzymes and Transporters.
Rani J Qasem, John K Fallon, Manisha Nautiyal, Merrie Mosedale, Philip C Smith

J Pharm Sci· January 2021

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Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury.
Andrew Gibson, Sean Hammond, Kanoot Jaruthamsophon, Sharin Roth, Merrie Mosedale

Chem Res Toxicol· November 2020

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Understanding Idiosyncratic Toxicity: Lessons Learned from Drug-Induced Liver Injury.
Merrie Mosedale, Paul B Watkins

J Med Chem· June 2020

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Identification of Candidate Risk Factor Genes for Human Idelalisib Toxicity Using a Collaborative Cross Approach.
Merrie Mosedale, Yanwei Cai, John Scott Eaddy, Robert W Corty, Manisha Nautiyal

Toxicol Sci· December 2019

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Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis.
Leah M Norona, Deborah G Nguyen, David A Gerber, Sharon C Presnell, Merrie Mosedale

PLoS One· September 2019

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Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury.
Natalie S Holman, Rachel J Church, Manisha Nautiyal, Kelly A Rose, Sarah E Thacker, Merrie Mosedale

Toxicol Sci· August 2019

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Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.
Diane M Longo, Jeffrey L Woodhead, Paul Walker, Krisztina Herédi-Szabó, Károly Mogyorósi, Merrie Mosedale

Toxicol Sci· February 2019

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Mouse Population-Based Approaches to Investigate Adverse Drug Reactions.
Merrie Mosedale

Drug Metab Dispos· November 2018

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Challenges and Solutions for Future Pharmacy Practice in the Era of Precision Medicine.
Olivia M Dong, Rachel M Howard, Rachel Church, Mackenzie Cottrell, Alan Forrest, Merrie Mosedale

Am J Pharm Educ· August 2018

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Optimized Methods to Explore the Mechanistic and Biomarker Potential of Hepatocyte-Derived Exosomes in Drug-Induced Liver Injury.
Sarah E Thacker, Manisha Nautiyal, Monicah A Otieno, Paul B Watkins, Merrie Mosedale

Toxicol Sci· May 2018

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Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa).
Merrie Mosedale, Donald Button, Jonathan P Jackson, Kimberly M Freeman, Kenneth R Brouwer

Toxicol Sci· February 2018

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miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.
Merrie Mosedale, J Scott Eaddy, O Joseph Trask, Natalie S Holman, Kristina K Wolf

Toxicol Sci· January 2018

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Editor's Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach.
Merrie Mosedale, Yunjung Kim, William J Brock, Sharin E Roth, Tim Wiltshire

Toxicol Sci· April 2017

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Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.
Jeffrey L Woodhead, William J Brock, Sharin E Roth, Susan E Shoaf, Kim L R Brouwer, Merrie Mosedale

Toxicol Sci· January 2017

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Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?
Natalie S Holman, Merrie Mosedale, Kristina K Wolf, Edward L LeCluyse, Paul B Watkins

Toxicol Sci· June 2016

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Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice.
Rachel J Church, Daniel M Gatti, Thomas J Urban, Nanye Long, Xi Yang, Merrie Mosedale

Food Chem Toxicol· February 2015

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Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug.
Merrie Mosedale, Hong Wu, C Lisa Kurtz, Stephen P Schmidt, Karissa Adkins

Toxicol Appl Pharmacol· October 2014

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A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis.
Rachel J Church, Hong Wu, Merrie Mosedale, Susan J Sumner, Wimal Pathmasiri

Toxicol Sci· August 2014

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PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans.
Timothy R Koves, Lauren M Sparks, J P Kovalik, Merrie Mosedale, Ramamani Arumugam

J Lipid Res· February 2013

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