Publications by authors named "Sharin Roth"

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Body fluid biomarkers and psychosis risk in The Accelerating Medicines Partnership® Schizophrenia Program: design considerations.
Diana O Perkins, Clark D Jeffries, Scott R Clark, Rachel Upthegrove, Cassandra M J Wannan, Sharin Roth

Schizophrenia (Heidelb)· May 2025

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Clinical Pattern of Tolvaptan-Associated Liver Injury in Trial Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD): An Analysis of Pivotal Clinical Trials.
David H Alpers, James H Lewis, Christine M Hunt, James W Freston, Vicente E Torres, Sharin E Roth

Am J Kidney Dis· March 2023

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Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite.
Sean Hammond, Andrew Gibson, Kanoot Jaruthamsophon, Sharin Roth, Merrie Mosedale

Toxicol Sci· January 2021

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Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury.
Andrew Gibson, Sean Hammond, Kanoot Jaruthamsophon, Sharin Roth, Merrie Mosedale

Chem Res Toxicol· November 2020

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Next-Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development.
Sharin E Roth, Mark I Avigan, David Bourdet, David Brott, Rachel Church

Clin Pharmacol Ther· February 2020

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Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease.
Jacqueline Bezençon, James J Beaudoin, Katsuaki Ito, Dong Fu, Sharin E Roth

Drug Metab Dispos· August 2019

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Soluble Urokinase Plasminogen Activator Receptor and Decline in Kidney Function in Autosomal Dominant Polycystic Kidney Disease.
Salim S Hayek, Douglas P Landsittel, Changli Wei, Martin Zeier, Alan S L Yu, Sharin Roth

J Am Soc Nephrol· July 2019

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Bile Acids as Potential Biomarkers to Assess Liver Impairment in Polycystic Kidney Disease.
William J Brock, James J Beaudoin, Jason R Slizgi, Mingming Su, Wei Jia, Sharin E Roth

Int J Toxicol· March 2019

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Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease.
James J Beaudoin, Jacqueline Bezençon, Yanguang Cao, Katsuhiko Mizuno, Sharin E Roth

Drug Metab Dispos· February 2019

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miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.
Merrie Mosedale, J Scott Eaddy, O Joseph Trask, Natalie S Holman, Kristina K Wolf, Sharin E Roth

Toxicol Sci· January 2018

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Editor's Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach.
Merrie Mosedale, Yunjung Kim, William J Brock, Sharin E Roth, Tim Wiltshire

Toxicol Sci· April 2017

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Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.
Jeffrey L Woodhead, William J Brock, Sharin E Roth, Susan E Shoaf, Kim L R Brouwer

Toxicol Sci· January 2017

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Simultaneous quantitation of delamanid (OPC-67683) and its eight metabolites in human plasma using UHPLC-MS/MS.
Min Meng, Benjamin Smith, Brad Johnston, Spencer Carter, Jerry Brisson, Sharin E Roth

J Chromatogr B Analyt Technol Biomed Life Sci· October 2015

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Development of Calcitonin Salmon Nasal Spray: similarity of peptide formulated in chlorobutanol compared to benzalkonium chloride as preservative.
Henry R Costantino, Heather Culley, Lishan Chen, Daniel Morris, Michael Houston, Sharin Roth

J Pharm Sci· October 2009

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