Publications by authors named "Kin Tam"

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Identifying meaningful drug response biomarkers from public pharmacogenomic datasets with biologically informed interpretable neural networks.
Maoxin Ran, Shao-Lin Zhang, Kin Yip Tam

Comput Biol Chem· February 2026

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miRNA-HK2 networks in cancer metabolism: Mechanisms and dual-targeting therapeutic opportunities.
Xinyue Jiang, Xinnan Li, Leo Tsz On Lee, Kin Yip Tam

Biochim Biophys Acta Rev Cancer· January 2026

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PPP2/PP2A-mediated dephosphorylation of LC3B links PINK1-PRKN/Parkin-mediated mitophagy to SCA12 pathogenesis.
Ningning Li, Hongyu Hou, Dan Su, Bojun Yang, Rui Ni, Kin Yip Tam

Autophagy· December 2025

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Benserazide‑mediated targeting hexokinase 2 enhances the cytotoxicity of cisplatin in non-small cell lung cancer cell models.
Kaifang Wang, Suya Wang, Wenying Shan, Shuting Huang, Tong Fang, Kin Yip Tam

Biochem Pharmacol· September 2025

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An orally administered quinolinium molecule mitigates neuropathology of Alzheimer's disease through modulation of mitochondrial dysfunction and neuroinflammation.
Junqiu He, Maoxin Ran, Kin Yip Tam

Brain Res· September 2025

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Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation.
Wenying Shan, Shao-Lin Zhang, Yehuda G Assaraf, Kin Yip Tam

Biochim Biophys Acta Mol Basis Dis· August 2025

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Pharmacological interventions on GSK3β phosphorylation-mediated tau aggregation by modulating phase separation of tau proline-rich domain.
Shan Sun, Siqian Chen, Junqiu He, Bojun Yang, Yingping Zhang, Kin Yip Tam

Biomed Pharmacother· August 2025

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Targeting Metabolic Vulnerabilities Reveals Hexokinase 2 as a Key Mediator of Resistance to Osimertinib in Non-Small Cell Lung Cancer Models.
Yizhen Guo, Ding Huang, Yan Zhou, Maoxin Ran, Shaolin Zhang, Kin Yip Tam

ACS Pharmacol Transl Sci· August 2025

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Synaptic Deficits in Adnp-Mutant Mice Are Ameliorated by Histone Demethylase LSD1 Inhibition.
Chih-Hung Lin, Yong Ren, Kin Wai Tam, Megan Conrow-Graham, Zhen Yan

Autism Res· July 2025

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Unexpected Discovery of a Novel Triphenylphosphonium Alkylalcohol That Triggers Cancer Cell Death via Mitophagy and Ferroptosis.
Ding Huang, Maojie Zhang, Haibo Yan, Ligang Mei, Aiming Yang, Kin Yip Tam

J Med Chem· June 2025

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Cognitive and Synaptic Impairment Induced by Deficiency of Autism Risk Gene and its Rescue by Histone Deacetylase Inhibition.
Pei Li, Siqi Men, Prachetas J Patel, Komal Saleem, Ping Zhong, Kin Wai Tam

bioRxiv· June 2025

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Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3β to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer's Disease.
Junqiu He, Shan Sun, Hongfeng Wang, Zheng Ying, Kin Yip Tam

Neurosci Bull· May 2025

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Targeting hexokinase 2 to enhance anticancer efficacy of trichosanthin in HeLa and SCC25 cell models.
Yan Zhou, Maoxin Ran, Wenying Shan, Kaifang Wang, Ou Sha, Kin Yip Tam

ADMET DMPK· September 2024

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Exploring casual effects and shared molecular mechanism between psoriasis and liver cancer through Mendelian randomization and comprehensive bioinformatic analyses.
Maoxin Ran, Ou Sha, Kin Yip Tam

Comput Biol Chem· June 2024

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ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction.
Shiqiang Xu, Qilian Ma, Junwen Shen, Ningning Li, Shan Sun, Kin Yip Tam

Acta Pharm Sin B· May 2024

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Dual-target inhibitors of cholinesterase and GSK-3β to modulate Alzheimer's disease.
Junqiu He, Kin Yip Tam

Drug Discov Today· April 2024

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Epigallocatechin gallate circumvents drug-induced resistance in non-small-cell lung cancer by modulating glucose metabolism and AMPK/AKT/MAPK axis.
Yan Zhou, Shiqi Huang, Yizhen Guo, Maoxin Ran, Wenying Shan, Kin Yip Tam

Phytother Res· December 2023

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Combined inhibition of pyruvate dehydrogenase kinase 1 and hexokinase 2 induces apoptsis in non-small cell lung cancer cell models.
Yizhen Guo, Xianchen Lu, Yan Zhou, Wen-Hua Chen, Kin Yip Tam

Exp Cell Res· December 2023

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Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing.
Yan Zhou, Yizhen Guo, Maoxin Ran, Wenying Shan, Carlotta Granchi, Kin Yip Tam

Cancer Lett· November 2023

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Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance.
Maoxin Ran, Yan Zhou, Yizhen Guo, Ding Huang, Shao-Lin Zhang, Kin Yip Tam

FEBS J· October 2023

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Repurposing the Hedgehog pathway inhibitor, BMS-833923, as a phosphatidylglycerol-selective membrane-disruptive colistin adjuvant against ESKAPE pathogens.
Nian Zhang, Wenying Shan, Liangliang Gao, Si Hoi Kou, Chang Lu, Kin Yip Tam

Int J Antimicrob Agents· September 2023

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UBQLN2 and HSP70 participate in Parkin-mediated mitophagy by facilitating outer mitochondrial membrane rupture.
Qilian Ma, Jiaqi Xin, Qiang Peng, Ningning Li, Shan Sun, Kin Yip Tam

EMBO Rep· September 2023

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Chlorpromazine affects autophagy in association with altered Rag GTPase-mTORC1-TFEB signaling.
Ningning Li, Lingling Rao, Xueqing Zhao, Junwen Shen, Dan Su, Kin Yip Tam

Front Cell Dev Biol· September 2023

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Transplanting Human Neural Stem Cells with ≈50% Reduction of SOX9 Gene Dosage Promotes Tissue Repair and Functional Recovery from Severe Spinal Cord Injury.
Jessica Aijia Liu, Kin Wai Tam, Yong Long Chen, Xianglan Feng, Christy Wing Lam Chan

Adv Sci (Weinh)· July 2023

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Clofazimine p Determination by Potentiometry and Spectrophotometry: Reverse Cosolvent Dependence as an Indicator of the Presence of Dimers in Aqueous Solutions.
Tatjana Ž Verbić, Kin Y Tam, Dušan Ž Veljković, Abu T M Serajuddin, Alex Avdeef

Mol Pharm· June 2023

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