Publications by authors named "Kin-Chow Chang"

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Research note: Use of in vitro and in ovo approaches to characterise avian influenza viruses and assess species specific responses to infection.
Lamyaa Al-Dalawi, Jiayun Yang, Adam M Blanchard, Michael Clark, Kin-Chow Chang

Poult Sci· December 2025

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An emerging PB2-627 polymorphism increases the zoonotic risk of avian influenza virus by overcoming ANP32 host restriction in mammalian and avian hosts.
Yuxin Guo, Sicheng Shu, Yong Zhou, Wenjing Peng, Zhimin Jiang, Kin-Chow Chang

J Virol· September 2025

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ApoD mediates age-associated increase in vulnerability to influenza virus infection.
Zhimin Jiang, Wenliang Pan, Yu Chen, Dongliang Zhou, Shuning Ren, Kin-Chow Chang

Proc Natl Acad Sci U S A· September 2025

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Impact of inactivated vaccine on transmission and evolution of H9N2 avian influenza virus in chickens.
Zhe Hu, Hui Ai, Zhen Wang, Shiyue Huang, Honglei Sun, Kin-Chow Chang

NPJ Vaccines· April 2025

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Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets.
Honglei Sun, Han Li, Qi Tong, Qiqi Han, Jiyu Liu, Haoyu Chang, Kin-Chow Chang

Cell· September 2023

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SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus.
Qiuchen Li, Zhimin Jiang, Shuning Ren, Hui Guo, Zhimin Song, Kin-Chow Chang

Adv Sci (Weinh)· December 2022

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Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals.
Chenxi Wang, Runkang Qu, Yanan Zong, Chao Qin, Litao Liu, Kin-Chow Chang

PLoS Pathog· July 2022

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N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammals.
Honglei Sun, Guojing Deng, Haoran Sun, Jingwei Song, Wei Zhang, Kin-Chow Chang

PNAS Nexus· July 2022

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Mink is a highly susceptible host species to circulating human and avian influenza viruses.
Honglei Sun, Fangtao Li, Qingzhi Liu, Jianyong Du, Litao Liu, Kin-Chow Chang

Emerg Microbes Infect· December 2021

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Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin.
Sarah Al-Beltagi, Leah V Goulding, Daniel K E Chang, Kenneth H Mellits, Christopher J Hayes, Kin-Chow Chang

Virulence· December 2021

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H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus inter-species infection in humans.
Fangtao Li, Jiyu Liu, Jizhe Yang, Haoran Sun, Zhimin Jiang, Kin-Chow Chang

PLoS Pathog· December 2021

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IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
Zhimin Jiang, Fanhua Wei, Yuying Zhang, Tong Wang, Weihua Gao, Kin-Chow Chang

Nat Microbiol· July 2021

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Reassortment with dominant chicken H9N2 influenza virus contributed to the fifth H7N9 virus human epidemic.
Juan Pu, Yanbo Yin, Jiyu Liu, Xinyu Wang, Yong Zhou, Kin-Chow Chang

J Virol· May 2021

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Neurovirulence of avian influenza virus is dependent on the interaction of viral NP protein with host factor FMRP in the murine brain.
Xuxiao Zhang, Juan Pu, Yipeng Sun, Bi Yuhai, Zhimin Jiang, Kin-Chow Chang

J Virol· March 2021

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Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus.
Sarah Al-Beltagi, Cristian Alexandru Preda, Leah V Goulding, Joe James, Juan Pu, Kin-Chow Chang

Viruses· February 2021

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Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus Replication.
Leah V Goulding, Jiayun Yang, Zhimin Jiang, Hongyu Zhang, Daniel Lea, Kin-Chow Chang

Viruses· September 2020

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Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection.
Honglei Sun, Yihong Xiao, Jiyu Liu, Dayan Wang, Fangtao Li, Kin-Chow Chang

Proc Natl Acad Sci U S A· July 2020

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Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells.
Weihua Gao, Zhipeng Zu, Jiyu Liu, Jingwei Song, Xinyu Wang, Kin-Chow Chang

J Gen Virol· September 2019

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Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses.
Tessa Slater, Isabella Eckerle, Kin-Chow Chang

Virol J· April 2018

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Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations.
Xuxiao Zhang, Guanlong Xu, Chenxi Wang, Ming Jiang, Weihua Gao, Kin-Chow Chang

J Gen Virol· June 2017

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M Gene Reassortment in H9N2 Influenza Virus Promotes Early Infection and Replication: Contribution to Rising Virus Prevalence in Chickens in China.
Juan Pu, Honglei Sun, Yi Qu, Chenxi Wang, Weihua Gao, Kin-Chow Chang

J Virol· April 2017

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Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity.
Guanlong Xu, Xuxiao Zhang, Weihua Gao, Chenxi Wang, Jinliang Wang, Kin-Chow Chang

J Virol· September 2016

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Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets.
Honglei Sun, Juan Pu, Yandi Wei, Yipeng Sun, Jiao Hu, Kin-Chow Chang

J Virol· July 2016

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Transmission and pathogenicity of novel reassortants derived from Eurasian avian-like and 2009 pandemic H1N1 influenza viruses in mice and guinea pigs.
Weili Kong, Qinfang Liu, Yipeng Sun, Yu Wang, Huijie Gao, Kin-Chow Chang

Sci Rep· June 2016

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Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation.
Pengxiang Chang, Suresh V Kuchipudi, Kenneth H Mellits, Sujith Sebastian, Joe James, Kin-Chow Chang

Sci Rep· December 2015

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