Publications by authors named "Kin-Fai Chan"

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F
Fabrication of a Lipopolysaccharide-Targeting Peptide-Based Colloid for Alleviating Carbapenem-Resistant Enterobacteriaceae-Induced Cutaneous Infection.
Ping Zeng, Xinyi Ding, Chenyu Liu, Sheng Chen, Kin-Fai Chan

Adv Healthc Mater· June 2025

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Overall mutational scanning unveils the essential active residues for the mechanistic action of MCR-1.
Qipeng Cheng, Yanchu Cheung, Chen Xu, Edward Wai Chi Chan, Kin Fai Chan

Microbiol Res· February 2025

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Repurposing cetylpyridinium chloride and domiphen bromide as phosphoethanolamine transferase inhibitor to combat colistin-resistant Enterobacterales.
Chen Xu, Qipeng Cheng, Kaichao Chen, Pui Kin So, Wenbin Jin, Edward Wai Chi Chan, Kin Fai Chan

Microbiol Res· November 2024

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Identification of isothiazolones analogues as potent bactericidal agents against antibiotic resistant CRE and MRSA strains.
Wenbin Jin, Chen Xu, Ning Dong, Kaichao Chen, Die Zhang, Kin-Fai Chan

BMC Chem· December 2023

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A novel ESKAPE-sensitive peptide with enhanced stability and its application in controlling multiple bacterial contaminations in chilled fresh pork.
Ping Zeng, Pengfei Zhang, Lanhua Yi, Kwok-Yin Wong, Sheng Chen, Kin-Fai Chan

Food Chem· July 2023

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C-terminal modification of a de novo designed antimicrobial peptide via capping of macrolactam rings.
Ping Zeng, Qipeng Cheng, Lanhua Yi, Sharon Shui Yee Leung, Sheng Chen, Kin-Fai Chan

Bioorg Chem· January 2023

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Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).
Iris L K Wong, Xuezhen Zhu, Kin-Fai Chan, Zhen Liu, Chin-Fung Chan, Tak Hang Chan

J Med Chem· October 2021

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An ornithine-rich dodecapeptide with improved proteolytic stability selectively kills gram-negative food-borne pathogens and its action mode on Escherichia coli O157:H7.
Ping Zeng, Lanhua Yi, Qipeng Cheng, Jun Liu, Sheng Chen, Kin-Fai Chan

Int J Food Microbiol· August 2021

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Investigation of antibiofilm activity, antibacterial activity, and mechanistic studies of an amphiphilic peptide against Acinetobacter baumannii.
Ping Zeng, Lanhua Yi, Jiangtao Xu, Wei Gao, Chen Xu, Kin-Fai Chan

Biochim Biophys Acta Biomembr· June 2021

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Bioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1,2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors.
Wen Bin Jin, Chen Xu, Qipeng Cheung, Wei Gao, Ping Zeng, Edward W C Chan, Tak Hang Chan, Kin-Fai Chan

Bioorg Chem· July 2020

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Hydrophobic substituents on isatin derivatives enhance their inhibition against bacterial peptidoglycan glycosyltransferase activity.
Yong Wang, Wing-Lam Cheong, Zhiguang Liang, Lok-Yan So, Kin-Fai Chan

Bioorg Chem· April 2020

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Designed Hexadecapeptides Synergize Glycopeptide Antibiotics Vancomycin and Teicoplanin against Pathogenic via Disruption of Cell Permeability and Potential.
Ping Zeng, Chen Xu, Chenyu Liu, Jun Liu, Qipeng Cheng, Kin-Fai Chan

ACS Appl Bio Mater· March 2020

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Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.
Xuezhen Zhu, Iris L K Wong, Kin-Fai Chan, Jiahua Cui, Man Chun Law, Tak Hang Chan

J Med Chem· September 2019

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Phenol-Soluble-Modulin-Inspired Amphipathic Peptides Have Bactericidal Activity against Multidrug-Resistant Bacteria.
Ping Zeng, Chen Xu, Qipeng Cheng, Jun Liu, Wei Gao, Kin-Fai Chan

ChemMedChem· August 2019

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Antibacterial activity and mechanism of action of a thiophenyl substituted pyrimidine derivative.
Zhiyuan Fang, Yanan Li, Yuanyuan Zheng, Xiaomei Li, Yu-Jing Lu, Kin-Fai Chan

RSC Adv· April 2019

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Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
Hok Kiu Lui, Wei Gao, Kwan Choi Cheung, Wen Bin Jin, Ning Sun, Edward W C Chan, Tak Hang Chan, Kin-Fai Chan

Eur J Med Chem· February 2019

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Design, synthesis and antibacterial evaluation of 2,4-disubstituted-6-thiophenyl-pyrimidines.
Zhiyuan Fang, Sichao Zheng, Kin-Fai Chan, Wenchang Yuan, Qi Guo, Tak-Hang Chan

Eur J Med Chem· January 2019

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Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".
Iris L K Wong, Xuezhen Zhu, Kin-Fai Chan, Man Chun Law, Aya M Y Lo, Tak Hang Chan

J Med Chem· November 2018

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Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1.
Wen Bin Jin, Chen Xu, Qipeng Cheng, Xiao Lin Qi, Wei Gao, Edward W C Chan, Tak Hang Chan, Kin-Fai Chan

Eur J Med Chem· July 2018

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Modified Penicillin Molecule with Carbapenem-Like Stereochemistry Specifically Inhibits Class C β-Lactamases.
Xuehua Pan, Yunjiao He, Tianfeng Chen, Kin-Fai Chan, Yanxiang Zhao

Antimicrob Agents Chemother· December 2017

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Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors.
Kin-Fai Chan, Ning Sun, Siu-Cheong Yan, Iris L K Wong, Hok-Kiu Lui, Fung-Yi Chan, Edward W C Chan, Tak Hang Chan

ACS Omega· October 2017

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Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1.
Lauriane Dury, Rachad Nasr, Doriane Lorendeau, Elisabeta Comsa, Iris Wong, Kin-Fai Chan, Tak-Hang Chan

Biochem Pharmacol· January 2017

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A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo.
Clare S W Yan, Iris L K Wong, Kin-Fai Chan, Jason W Y Kan, Tsz Cheung Chong, Shun Wan Chan, Tak Hang Chan

Mol Pharm· October 2015

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Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1).
Jiachi Chiou, Shengbiao Wan, Kin-Fai Chan, Pui-Kin So, Dandan He, Edward Wai-chi Chan, Tak-hang Chan

Chem Commun (Camb)· June 2015

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Structure-based design, synthesis, and biological evaluation of isatin derivatives as potential glycosyltransferase inhibitors.
Yong Wang, Fung-Yi Chan, Ning Sun, Hok-Kiu Lui, Pui-Kin So, Kin-Fai Chan

Chem Biol Drug Des· December 2014

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