Publications by authors named "Kirk Knowlton"

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Cardiomyocyte β-arrestins mediate inflammation and cGAS-STING activation in CVB3 viral myocarditis.
Emilio Y Lucero, Haoran Jiang, Vincent D'Anniballe, Natalia Pakharukova, Daniella Galtes, Kirk U Knowlton

Am J Physiol Heart Circ Physiol· January 2026

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Observational and Mendelian randomization studies of plasma sclerostin levels do not provide evidence of cardiovascular adverse effects of sclerostin inhibition.
Rosa B Thorolfsdottir, Gardar Sveinbjornsson, Grimur Hjorleifsson Eldjarn, Hildur M Aegisdottir, Unnur Styrkarsdottir, Kirk U Knowlton

Hum Mol Genet· December 2025

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Recurrent right atrial myxoma presenting as pulmonary hypertension and peripheral pulmonary artery aneurysms.
Jacob C Taylor, Kirk U Knowlton, Thomas C Wilson, Mark W Dodson

Thorax· December 2025

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Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.
Aeron M Small, Ta-Yu Yang, Shinsuke Itoh, Sébastien Thériault, Line Dufresne, Kirk U Knowlton

Nat Genet· December 2025

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Association of study visit interval length with follow-up completeness and adherence to assigned study drug dose: A randomized comparison of participants in the ADAPTABLE trial.
Dennis I Narcisse, Jeff Whittle, Grace M Rhodes, Amanda L Stebbins, Lisa M Wruck, Kirk U Knowlton

Contemp Clin Trials· September 2025

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Genome-wide meta-analysis identifies nine loci associated with higher risk of hepatocellular carcinoma development.
Jonas Ghouse, Helene Gellert-Kristensen, Colm J O'Rourke, Anne-Sofie Seidelin, Gudmar Thorleifsson, Kirk U Knowlton

JHEP Rep· September 2025

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Does Sex or Age Impact the Prognostic Value of a Zero Coronary Artery Calcium Score?
Jeffrey L Anderson, Dave S Collingridge, Viet T Le, Leslie Iverson, Joseph B Muhlestein, Kirk U Knowlton

J Clin Med· September 2025

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The genetic architecture of fibromyalgia across 2.5 million individuals.
Isabel Kerrebijn, Gyda Bjornsdottir, Keon Arbabi, Lea Urpa, Hele Haapaniemi, Kirk U Knowlton

medRxiv· September 2025

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Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy.
Michele Nicastro, Alexa M C Vermeer, Pieter G Postema, Rafik Tadros, Forrest Z Bowling, Kirk U Knowlton

Am J Hum Genet· July 2025

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Passive immunotherapy for adults hospitalized with COVID-19: An individual participant data meta-analysis of six randomized controlled trials.
Kirk U Knowlton, Lianne K Siegel, Christina E Barkauskas, Sanjay Bhagani, Nila J Dharan

PLoS Med· July 2025

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Atrial Fibrillation as a Predictor of Age-Related Macular Degeneration.
Kaden T Bunch, Heidi T May, Kirk U Knowlton, Tami L Bair, J Brent Muhlestein

J Cardiovasc Electrophysiol· May 2025

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A genome-wide association meta-analysis links hidradenitis suppurativa to common and rare sequence variants causing disruption of the Notch and Wnt/β-catenin signaling pathways.
Rune Kjærsgaard Andersen, Lilja Stefansdottir, Peter Theut Riis, Gisli Halldorsson, Egil Ferkingstad, Kirk U Knowlton

J Am Acad Dermatol· April 2025

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Missense variants in FRS3 affect body mass index in populations of diverse ancestries.
Andrea B Jonsdottir, Gardar Sveinbjornsson, Rosa B Thorolfsdottir, Max Tamlander, Vinicius Tragante, Kirk U Knowlton

Nat Commun· March 2025

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Weight loss-independent changes in human growth hormone during water-only fasting: a secondary evaluation of a randomized controlled trial.
Benjamin D Horne, Jeffrey L Anderson, Heidi T May, Tami L Bair, Viet T Le, Kirk U Knowlton

Front Endocrinol (Lausanne)· February 2025

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Genome-Wide Association Study of Accessory Atrioventricular Pathways.
Hildur M Aegisdottir, Laura Andreasen, Rosa B Thorolfsdottir, Gardar Sveinbjornsson, Andrea B Jonsdottir, Kirk U Knowlton

JAMA Cardiol· November 2024

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Insulin resistance reduction, intermittent fasting, and human growth hormone: secondary analysis of a randomized trial.
Benjamin D Horne, Jeffrey L Anderson, Heidi T May, Tami L Bair, Viet T Le, Kirk U Knowlton

NPJ Metab Health Dis· October 2024

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Framework of the strengths and challenges of clinically integrated trials: An expert panel report.
Anthony E Peters, W Schuyler Jones, Brian Anderson, Carolyn T Bramante, Uli Broedl, Kirk U Knowlton

Am Heart J· September 2024

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Contribution of Clinical Trial Event Data by Data Source: A Prespecified Analysis of the ADAPTABLE Randomized Clinical Trial.
Jennifer A Rymer, Hillary Mulder, Lisa M Wruck, Daniel Muñoz, Sunil Kripalani, Kirk U Knowlton

JAMA Cardiol· September 2024

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Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease.
Saedis Saevarsdottir, Kristbjörg Bjarnadottir, Thorsteinn Markusson, Jonas Berglund, Thorunn A Olafsdottir, Kirk U Knowlton

Nat Commun· July 2024

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Biallelic variants in cause a novel autosomal recessive syndrome presenting with cardiac conduction defects and variable hypertrophic cardiomyopathy.
Michele Nicastro, Alexa M C Vermeer, Pieter G Postema, Rafik Tadros, Forrest Z Bowling, Kirk U Knowlton

medRxiv· July 2024

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Homozygosity for R47H in and the Risk of Alzheimer's Disease.
Hreinn Stefansson, G Bragi Walters, Gardar Sveinbjornsson, Vinicius Tragante, Gudmundur Einarsson, Kirk U Knowlton

N Engl J Med· June 2024

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Association of Short-Term Increases in Ambient Fine Particulate Matter With Hospitalization for Asthma or COPD During Wildfire Season and Other Time Periods.
Benjamin D Horne, Mary M Johnson, Denitza P Blagev, Francois Haddad, Kirk U Knowlton

CHEST Pulm· June 2024

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Periodic Fasting and Acute Cardiac Events in Patients Evaluated for COVID-19: An Observational Prospective Cohort Study.
Benjamin D Horne, Jeffrey L Anderson, Francois Haddad, Heidi T May, Viet T Le, Kirk U Knowlton

Nutrients· June 2024

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Impact of Active vs Passive Statin Selection for Primary Prevention: The CorCal Vanguard Trial.
Jeffrey L Anderson, Kirk U Knowlton, Heidi T May, Viet T Le, Donald L Lappe'

JACC Adv· December 2023

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Impact of Statin Therapy in Heart Failure Patients: Results of a Large Real-World Experience.
Jeffrey L Anderson, Heidi T May, Viet T Le, Joseph B Muhlestein, Benjamin D Horne, Kirk U Knowlton

JACC Adv· June 2023

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