Publications by authors named "Saedis Saevarsdottir"

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Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource.
Unnur Styrkarsdottir, Sigrun H Lund, Gudmar Thorleifsson, Saedis Saevarsdottir, Daniel F Gudbjartsson, Unnur Thorsteinsdottir, Kari Stefansson

Arthritis Rheumatol· April 2023

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Genome-wide association study and polygenic risk prediction of hypothyroidism.
Søren A Rand, Gustav Ahlberg, Vinicius Tragante, Laia M Monfort, Chaoqun Zheng, Saedis Saevarsdottir

Nat Genet· December 2025

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African-ancestry-specific variant IKKβ p.Glu502Lys confers high lupus risk.
Gudny Ella Thorlacius, Erna V Ivarsdottir, Saedis Saevarsdottir, Kristjan H S Moore, Sigurjon A Gudjonsson

Nat Genet· December 2025

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Autoantibody-defined subsets of patients with systemic lupus erythematosus associate with clinical manifestations, NCF2, and HLA DR3-DQ2 genotypes.
Henrik Christian Bidstrup Leffers, Anne Troldborg, Martin Andersen, Ana Cristina Gonzalez Sanchez, Ingileif Jonsdottir, Saedis Saevarsdottir

Transl Res· October 2025

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Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the HLA Class II Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthritis.
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Saedis Saevarsdottir

Arthritis Rheumatol· September 2025

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The genetic architecture of fibromyalgia across 2.5 million individuals.
Isabel Kerrebijn, Gyda Bjornsdottir, Keon Arbabi, Lea Urpa, Hele Haapaniemi, Saedis Saevarsdottir

medRxiv· September 2025

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Common genetic variants do not impact clinical prediction of methotrexate treatment outcomes in early rheumatoid arthritis.
Anton Öberg Sysojev, Bénédicte Delcoigne, Thomas Frisell, Lars Alfredsson, Lars Klareskog, Saedis Saevarsdottir

J Intern Med· June 2025

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Association of matrix metalloproteinase 7 and the alpha-chain of fibrinogen at baseline with response to methotrexate at 3 months in patients with early rheumatoid arthritis.
Karen Hambardzumyan, Carl Hamsten, Lucía Lourido, Saedis Saevarsdottir, Peter Nilsson

BMC Rheumatol· May 2025

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In early rheumatoid arthritis, comorbidities do not explain the increased risk of failure to reach remission in patients with obesity.
Liselotte Tidblad, Anton Öberg Sysojev, Bénédicte Delcoigne, Lars Klareskog, Lars Alfredsson, Saedis Saevarsdottir

RMD Open· April 2025

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The impact of autoantibodies on the efficacy of biological disease-modifying anti-rheumatic drugs in rheumatoid arthritis: meta-analysis of randomized controlled trials.
Kaoru Takase-Minegishi, Stefan Böhringer, Jackie L Nam, Yuko Kaneko, Frank Behrens, Saedis Saevarsdottir

Rheumatology (Oxford)· February 2025

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A partial loss-of-function variant in STAT6 protects against type 2 asthma.
Katla Kristjansdottir, Gudmundur L Norddahl, Erna V Ivarsdottir, Gisli H Halldorsson, Gudmundur Einarsson, Saedis Saevarsdottir

J Allergy Clin Immunol· January 2025

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Legal obstacles jeopardise research in personalised medicine - experiences from a Nordic collaboration within rheumatology.
Bente Glintborg, Mats Hansson, Hilde Berner Hammer, Lars Klareskog, Saedis Saevarsdottir

Scand J Public Health· December 2024

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Genome-Wide Association Study of Accessory Atrioventricular Pathways.
Hildur M Aegisdottir, Laura Andreasen, Rosa B Thorolfsdottir, Gardar Sveinbjornsson, Andrea B Jonsdottir, Saedis Saevarsdottir

JAMA Cardiol· November 2024

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Gene-based burden tests of rare germline variants identify six cancer susceptibility genes.
Erna V Ivarsdottir, Julius Gudmundsson, Vinicius Tragante, Gardar Sveinbjornsson, Snaedis Kristmundsdottir, Saedis Saevarsdottir

Nat Genet· November 2024

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Minor Genetic Overlap Among Rheumatoid Arthritis, Myocardial Infarction, and Myocardial Infarction Risk Determinants.
Anton Öberg Sysojev, Lars Alfredsson, Lars Klareskog, , Gilad N Silberberg, Saedis Saevarsdottir

Arthritis Rheumatol· September 2024

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Sequence variants influencing the regulation of serum IgG subclass levels.
Thorunn A Olafsdottir, Gudmar Thorleifsson, Aitzkoa Lopez de Lapuente Portilla, Stefan Jonsson, Lilja Stefansdottir, Saedis Saevarsdottir

Nat Commun· September 2024

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The correlation between CpG methylation and gene expression is driven by sequence variants.
Olafur Andri Stefansson, Brynja Dogg Sigurpalsdottir, Solvi Rognvaldsson, Gisli Hreinn Halldorsson, Kristinn Juliusson, Saedis Saevarsdottir

Nat Genet· August 2024

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Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease.
Saedis Saevarsdottir, Kristbjörg Bjarnadottir, Thorsteinn Markusson, Jonas Berglund, Thorunn A Olafsdottir

Nat Commun· July 2024

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Author Correction: Large-scale plasma proteomics comparisons through genetics and disease associations.
Grimur Hjorleifsson Eldjarn, Egil Ferkingstad, Sigrun H Lund, Hannes Helgason, Olafur Th Magnusson, Saedis Saevarsdottir

Nature· June 2024

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Disease-modifying antirheumatic drugs and risk of thyroxine-treated autoimmune thyroid disease in patients with rheumatoid arthritis.
Kristin Waldenlind, Bénédicte Delcoigne, Saedis Saevarsdottir, Johan Askling

J Intern Med· March 2024

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In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation.
Eleftheria Pertsinidou, Saedis Saevarsdottir, Vivek Anand Manivel, Lars Klareskog, Lars Alfredsson

Ann Rheum Dis· February 2024

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Variants at the Interleukin 1 Gene Locus and Pericarditis.
Rosa B Thorolfsdottir, Andrea B Jonsdottir, Gardar Sveinbjornsson, Hildur M Aegisdottir, Asmundur Oddsson, Saedis Saevarsdottir

JAMA Cardiol· February 2024

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Comorbidities and chance of remission in patients with early rheumatoid arthritis receiving methotrexate as first-line therapy: a Swedish observational nationwide study.
Liselotte Tidblad, Helga Westerlind, Bénédicte Delcoigne, Johan Askling, Saedis Saevarsdottir

RMD Open· December 2023

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Remission, response, retention and persistence to treatment with disease-modifying agents in patients with rheumatoid arthritis: a study of harmonised Swedish, Danish and Norwegian cohorts.
Helga Westerlind, Bente Glintborg, Hilde Berner Hammer, Saedis Saevarsdottir, Niels Steen Krogh

RMD Open· September 2023

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Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria.
Ragnar P Kristjansson, Gudjon R Oskarsson, Astros Skuladottir, Asmundur Oddsson, Solvi Rognvaldsson, Saedis Saevarsdottir

Commun Biol· July 2023

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