Publications by authors named "Kiyoshi Isobe"

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[Long-Term Survival by Low-Dose Imatinib after Recurrence of GIST].
Yosuke Mihara, Takashi Ando, Masanori Hayashi, Koji Atsuta, Takamori Nakayama, Kiyoshi Isobe

Gan To Kagaku Ryoho· January 2022

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Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents.
Shinya Fujii, Eriko Kikuchi, Honoka Suzuyama, Yuko Watanabe, Mari Ishigami-Yuasa, Kiyoshi Isobe

ChemMedChem· September 2021

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Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia.
Wakana Shoda, Naohiro Nomura, Fumiaki Ando, Hideaki Tagashira, Takahiro Iwamoto, Kiyoshi Isobe

PLoS One· September 2020

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Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling.
Shinya Fujii, Eriko Kikuchi, Yuko Watanabe, Honoka Suzuyama, Mari Ishigami-Yuasa, Kiyoshi Isobe

Bioorg Med Chem Lett· September 2020

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Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease.
Taisuke Furusho, Eisei Sohara, Shintaro Mandai, Hiroaki Kikuchi, Naohiro Takahashi, Kiyoshi Isobe

Kidney Int· April 2020

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CRISPR-Cas9/phosphoproteomics identifies multiple noncanonical targets of myosin light chain kinase.
Kiyoshi Isobe, Viswanathan Raghuram, Laya Krishnan, Chung-Lin Chou, Chin-Rang Yang

Am J Physiol Renal Physiol· March 2020

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Nationwide in-hospital mortality following major fractures among hemodialysis patients and the general population: An observational cohort study.
Shintaro Mandai, Hidehiko Sato, Soichiro Iimori, Shotaro Naito, Haruna Tanaka, Kiyoshi Isobe

Bone· January 2020

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A case of tracheal obstruction caused by reflux and aspiration of semi-solid nutrients via the nasogastric tube.
Masatoshi Nakagawa, Kaori Sugihara, Kiyoshi Isobe, Masafumi Akasu, Kazutaka Tsujimoto

Int J Surg Case Rep· November 2019

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Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium-potassium-2 chloride cotransporter and sodium-chloride cotransporter.
Yoshiaki Matsuura, Naohiro Nomura, Wakana Shoda, Takayasu Mori, Kiyoshi Isobe

Biochem Biophys Res Commun· September 2019

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Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation.
Tamami Fujiki, Fumiaki Ando, Kana Murakami, Kiyoshi Isobe, Takayasu Mori

Sci Rep· June 2019

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Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease.
Hiroaki Kikuchi, Emi Sasaki, Naohiro Nomura, Takayasu Mori, Yoji Andrew Minamishima, Kiyoshi Isobe

Kidney Int· January 2019

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Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo.
Sayaka Yoshida, Yuya Araki, Takayasu Mori, Emi Sasaki, Yuri Kasagi, Kiyoshi Isobe

Clin Exp Nephrol· December 2018

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Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter.
Hiroko Hashimoto, Naohiro Nomura, Wakana Shoda, Kiyoshi Isobe, Hiroaki Kikuchi

Metabolism· August 2018

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Systems-level identification of PKA-dependent signaling in epithelial cells.
Kiyoshi Isobe, Hyun Jun Jung, Chin-Rang Yang, J'Neka Claxton, Pablo Sandoval

Proc Natl Acad Sci U S A· October 2017

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The proteasome inhibitor bortezomib attenuates renal fibrosis in mice via the suppression of TGF-β1.
Moko Zeniya, Takayasu Mori, Naofumi Yui, Naohiro Nomura, Shintaro Mandai, Kiyoshi Isobe

Sci Rep· October 2017

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Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.
Emi Sasaki, Koichiro Susa, Takayasu Mori, Kiyoshi Isobe, Yuya Araki

Mol Cell Biol· April 2017

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Evaluation of Phosphorylated Urinary Na-Cl Cotransporter Is Potentially Useful in a Patient With Pseudohypoaldosteronism Type II due to Mutation in CUL3.
Keiko Nagahara, Yoshifusa Abe, Akira Hojo, Kazushige Dobashi, Motoko Chiga, Kiyoshi Isobe

Glob Pediatr Health· June 2016

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Photoinduced bending of rod-like millimetre-size crystals of a rhodium dithionite complex with n-pentyl moieties.
Hidetaka Nakai, Kengo Matsuba, Masataka Akimoto, Tomonori Nozaki, Takahiro Matsumoto, Kiyoshi Isobe

Chem Commun (Camb)· March 2016

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Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.
Yuki Yoshizaki, Yutaro Mori, Yoshihito Tsuzaki, Takayasu Mori, Naohiro Nomura, Kiyoshi Isobe

Biochem Biophys Res Commun· November 2015

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Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene.
Yuya Araki, Tatemitsu Rai, Eisei Sohara, Takayasu Mori, Yuichi Inoue, Kiyoshi Isobe

Biol Open· October 2015

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Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus.
Moko Zeniya, Nobuhisa Morimoto, Daiei Takahashi, Yutaro Mori, Takayasu Mori, Kiyoshi Isobe

J Am Soc Nephrol· September 2015

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Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.
Eriko Kikuchi, Takayasu Mori, Moko Zeniya, Kiyoshi Isobe, Mari Ishigami-Yuasa

J Am Soc Nephrol· July 2015

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PiCO2 monitoring of transferred jejunum perfusion using an air tonometry technique after hypopharyngeal cancer surgery.
Hiroyuki Ozawa, Yorihisa Imanishi, Fumihiro Ito, Yoshihiro Watanabe, Takashi Kato, Kiyoshi Isobe

Medicine (Baltimore)· March 2015

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Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.
Koichiro Susa, Eisei Sohara, Tatemitsu Rai, Moko Zeniya, Yutaro Mori, Kiyoshi Isobe

Hum Mol Genet· October 2014

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[Marginal zone lymphoma of mucosa-associated lymphoid tissue of the parietal pleura; report of a case].
Takashi Inoue, Hirohisa Inaba, Noriko Oshima, Kouji Atsuta, Reiko Shimojima, Kiyoshi Isobe

Kyobu Geka· February 2014

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