Publications by authors named "Klara Haldimann"

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Correction: Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.
Suresh Dharuman, Gregory A Phelps, Christine M Dunn, Laura A Wilt, Patricia A Murphy, Klara Haldimann

J Antibiot (Tokyo)· January 2025

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Phenotypic Differentiation Within the ' Aminoglycoside Resistance Gene Family Suggests a Novel Subtype IV of Contemporary Clinical Relevance.
Michel Plattner, Maurizio Catelani, Sarah-Lisa Gmür, Maximilian Hartmann, Fatmanur Kiliç, Klara Haldimann

Antibiotics (Basel)· December 2024

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Synthesis and antibacterial action of 3',6'-disubstituted spectinomycins.
Suresh Dharuman, Gregory A Phelps, Christine M Dunn, Laura A Wilt, Patricia A Murphy, Klara Haldimann

J Antibiot (Tokyo)· September 2024

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Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models.
Niels Frimodt-Møller, Jon U Hansen, Michel Plattner, Douglas L Huseby, Stine Radmer Almind, Klara Haldimann

Int J Antimicrob Agents· July 2024

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L-carnitine co-administration prevents colistin-induced mitochondrial permeability transition and reduces the risk of acute kidney injury in mice.
Sophia L Samodelov, Zhibo Gai, Francesca De Luca, Klara Haldimann, Sven N Hobbie

Sci Rep· July 2024

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Phenotypic and genotypic characterization of isolates among individuals at high risk for sexually transmitted diseases in Zurich, Switzerland.
Christian Jünger, Frank Imkamp, Suraj Balakrishna, Marina Gysin, Klara Haldimann

Int J STD AIDS· May 2024

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Site-Selective Palladium-catalyzed Oxidation of Unprotected Aminoglycosides and Sugar Phosphates.
Nittert Marinus, Niels R M Reintjens, Klara Haldimann, Marc L M C Mouthaan, Sven N Hobbie

Chemistry· April 2024

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Experimental Determination of the p Values of Clinically Relevant Aminoglycoside Antibiotics: Toward Establishing p-Activity Relationships.
Ruslans Muhamadejevs, Klara Haldimann, Marina Gysin, David Crich, Kristaps Jaudzems

ACS Omega· February 2024

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Synthesis of Gentamicins C1, C2, and C2a and Antiribosomal and Antibacterial Activity of Gentamicins B1, C1, C1a, C2, C2a, C2b, and X2.
Santanu Jana, Parasuraman Rajasekaran, Klara Haldimann, Andrea Vasella, Erik C Böttger

ACS Infect Dis· August 2023

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Comparison of Disk Diffusion, E-Test, and Broth Microdilution Methods for Testing In Vitro Activity of Cefiderocol in .
Natalia Kolesnik-Goldmann, Helena M B Seth-Smith, Klara Haldimann, Frank Imkamp, Tim Roloff

Antibiotics (Basel)· July 2023

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Synthesis of 4--(4-Amino-4-deoxy-β-D-xylopyranosyl)paromomycin and 4--(β-D-Xylopyranosyl)-4-deoxy-4'-thio-paromomycin and Evaluation of their Antiribosomal and Antibacterial Activity.
Rukshana Mohamad-Ramshan, Chennaiah Ande, Takahiko Matsushita, Klara Haldimann, Andrea Vasella

Tetrahedron· April 2023

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Importance of Co-operative Hydrogen Bonding in the Apramycin-Ribosomal Decoding A-Site Interaction.
Michael G Pirrone, Chennaiah Ande, Klara Haldimann, Sven N Hobbie, Andrea Vasella

ChemMedChem· January 2023

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Synthesis, Antibacterial and Antiribosomal Activity of the 3-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5--Ribofuranosyl Apramycins).
Dmitrijs Lubriks, Klara Haldimann, Sven N Hobbie, Andrea Vasella, Edgars Suna

Antibiotics (Basel)· December 2022

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Apramycin susceptibility of multidrug-resistant Gram-negative blood culture isolates in five countries in Southeast Asia.
Marina Gysin, Pei Yun Hon, Pisey Tan, Amphonesavanh Sengduangphachanh, Manivone Simmalavong, Klara Haldimann

Int J Antimicrob Agents· October 2022

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Structure-Activity Relationships for 5'' Modifications of 4,5-Aminoglycoside Antibiotics.
Jonathan C K Quirke, Girish C Sati, Amr Sonousi, Marina Gysin, Klara Haldimann

ChemMedChem· July 2022

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Genotypic and phenotypic analyses of aac(3) aminoglycoside-resistance gene diversity point to three distinct phenotypes of contemporary clinical relevance.
Michel Plattner, Chloé Goyet, Klara Haldimann, Marina Gysin, Mario Juhas

J Glob Antimicrob Resist· June 2022

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Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
Katja Becker, Sha Cao, Anna Nilsson, Maria Erlandsson, Sven-Kevin Hotop, Klara Haldimann

EBioMedicine· November 2021

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Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
Katja Becker, Vincent Aranzana-Climent, Sha Cao, Anna Nilsson, Reza Shariatgorji, Klara Haldimann

Clin Microbiol Infect· September 2021

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Antimicrobial susceptibility patterns of respiratory Gram-negative bacterial isolates from COVID-19 patients in Switzerland.
Marina Gysin, Claudio Tirso Acevedo, Klara Haldimann, Elias Bodendoerfer, Frank Imkamp

Ann Clin Microbiol Antimicrob· September 2021

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Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5''- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes.
Dimitrijs Lubriks, Rimants Zogota, Vikram A Sarpe, Takahiko Matsushita, Girish C Sati, Klara Haldimann

ACS Infect Dis· August 2021

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An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity.
Amr Sonousi, Jonathan C K Quirke, Prabuddha Waduge, Tanja Janusic, Marina Gysin, Klara Haldimann

ChemMedChem· January 2021

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Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site.
Michael G Pirrone, Marina Gysin, Klara Haldimann, Sven N Hobbie, Andrea Vasella

J Org Chem· December 2020

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Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene .
Michel Plattner, Marina Gysin, Klara Haldimann, Katja Becker, Sven N Hobbie

Int J Mol Sci· August 2020

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Apralogs: Apramycin 5--Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
Jonathan C K Quirke, Parasuraman Rajasekaran, Vikram A Sarpe, Amr Sonousi, Ivan Osinnii, Klara Haldimann

J Am Chem Soc· January 2020

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Synthesis of saccharocin from apramycin and evaluation of its ribosomal selectivity.
Vikram A Sarpe, Michael G Pirrone, Klara Haldimann, Sven N Hobbie, Andrea Vasella

Medchemcomm· April 2019

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