Publications by authors named "Klaus Seuwen"

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Loss of proton-sensing GPR4 reduces tumor progression in mouse models of colon cancer.
Leonie Perren, Moana Busch, Pedro A Ruiz, Ermanno Malagola, Valeria Baumeler, Klaus Seuwen

Mol Oncol· May 2025

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The Simultaneous Deletion of pH-Sensing Receptors GPR4 and OGR1 (GPR68) Ameliorates Colitis with Additive Effects on Multiple Parameters of Inflammation.
Federica Foti, Cordelia Schuler, Pedro A Ruiz, Leonie Perren, Ermanno Malagola, Klaus Seuwen

Int J Mol Sci· February 2025

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Accelerated remyelination and immune modulation by the EBI2 agonist 7α,25-dihydroxycholesterol analogue in the cuprizone model.
Klaudia Konieczna-Wolska, Fionä Caratis, Mikołaj Opiełka, Karol Biernacki, Krzysztof Urbanowicz, Klaus Seuwen

Biomed Pharmacother· December 2024

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Molecular characterization of chronic cutaneous wounds reveals subregion- and wound type-specific differential gene expression.
Shola Michelle Richards, Caroline Gubser Keller, Robert Kreutzer, Géraldine Greiner, Svenja Ley, Klaus Seuwen

Int Wound J· April 2024

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Role of pH-sensing receptors in colitis.
Martin Hausmann, Klaus Seuwen, Cheryl de Vallière, Moana Busch, Pedro A Ruiz

Pflugers Arch· April 2024

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The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.
Fionä Caratis, Mikołaj Opiełka, Martin Hausmann, Maria Velasco-Estevez, Bartłomiej Rojek, Klaus Seuwen

PLoS One· March 2024

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OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation.
Leonie Perren, Moana Busch, Cordelia Schuler, Pedro A Ruiz, Federica Foti, Klaus Seuwen

Int J Mol Sci· October 2023

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Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism.
James P Bridges, Caterina Safina, Bernard Pirard, Kari Brown, Alyssa Filuta, Klaus Seuwen

Elife· September 2022

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New Therapeutic Approach for Intestinal Fibrosis Through Inhibition of pH-Sensing Receptor GPR4.
Bruce Weder, Fabian Schefer, Wouter Tobias van Haaften, Eleonora Patsenker, Felix Stickel, Klaus Seuwen

Inflamm Bowel Dis· January 2022

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pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis.
Cheryl de Vallière, Jesus Cosin-Roger, Katharina Baebler, Anja Schoepflin, Céline Mamie, Klaus Seuwen

Int J Mol Sci· January 2022

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Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling.
Manuel Hayn, Andrea Blötz, Armando Rodríguez, Solange Vidal, Nico Preising, Klaus Seuwen

Proc Natl Acad Sci U S A· January 2021

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Targeting interleukin-4 to the arthritic joint.
Valerie Spieler, Marie-Gabrielle Ludwig, Janet Dawson, Bruno Tigani, Amanda Littlewood-Evans, Klaus Seuwen

J Control Release· October 2020

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The RESOLUTE consortium: unlocking SLC transporters for drug discovery.
Giulio Superti-Furga, Daniel Lackner, Tabea Wiedmer, Alvaro Ingles-Prieto, Barbara Barbosa, Klaus Seuwen

Nat Rev Drug Discov· July 2020

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The proton-activated ovarian cancer G protein-coupled receptor 1 (OGR1) is responsible for renal calcium loss during acidosis.
Pedro Henrique Imenez Silva, Chahira Katamesh-Benabbas, Kessara Chan, Eva Maria Pastor Arroyo, Thomas Knöpfel, Klaus Seuwen

Kidney Int· May 2020

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Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2.
Katharina R Beck, Sharavan Kanagaratnam, Denise V Kratschmar, Julia Birk, Hideaki Yamaguchi, Klaus Seuwen

J Steroid Biochem Mol Biol· June 2019

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Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease.
Irina Tcymbarevich, Shola M Richards, Giancarlo Russo, Jelena Kühn-Georgijevic, Jesus Cosin-Roger, Klaus Seuwen

J Crohns Colitis· February 2019

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The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.
Irina V Tcymbarevich, Jyrki J Eloranta, Jean-Benoît Rossel, Nicole Obialo, Marianne Spalinger, Klaus Seuwen

BMC Gastroenterol· January 2019

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SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney.
Muriel Auberson, Sophie Stadelmann, Candice Stoudmann, Klaus Seuwen, Robert Koesters

Pflugers Arch· December 2018

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Glucocorticoid-loaded liposomes induce a pro-resolution phenotype in human primary macrophages to support chronic wound healing.
Anne Gauthier, Andreas Fisch, Klaus Seuwen, Birgit Baumgarten, Heinz Ruffner

Biomaterials· September 2018

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Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization.
Ewa Surdziel, Ieuan Clay, Florian Nigsch, Anke Thiemeyer, Cyril Allard, Klaus Seuwen

PLoS One· October 2017

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A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia.
Thomas Suply, Sébastien Hannedouche, Nathalie Carte, Jianping Li, Bianka Grosshans, Klaus Seuwen

Sci Signal· September 2017

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Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.
Wolfgang Miltz, Juraj Velcicky, Janet Dawson, Amanda Littlewood-Evans, Marie-Gabrielle Ludwig, Klaus Seuwen

Bioorg Med Chem· August 2017

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Adhesion GPCR Function in Pulmonary Development and Disease.
Marie-Gabrielle Ludwig, Klaus Seuwen, James P Bridges

Handb Exp Pharmacol· June 2017

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Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling.
Kari Brown, Alyssa Filuta, Marie-Gabrielle Ludwig, Klaus Seuwen, Julian Jaros

JCI Insight· June 2017

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Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein-Coupled Receptor OGR1 (GPR68).
Cheryl de Vallière, Jesus Cosin-Roger, Simona Simmen, Kirstin Atrott, Hassan Melhem, Klaus Seuwen

Cell Mol Gastroenterol Hepatol· November 2016

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