Publications by authors named "Koki Chiba"

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Metabolic adaptation to acute metabolic stress via PFKFB3 upregulation in rodent beta cells.
Koki Chiba, Hiroshi Nomoto, Rimi Izumihara, Xinxin Zhang, Hiraku Kameda

Front Endocrinol (Lausanne)· July 2025

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Analyses of the onset mechanisms of cardio-stimulatory action by aciclovir.
Ai Goto, Ryuichi Kambayashi, Koki Chiba, Makoto Shinozaki, Kiryu Moritani

J Pharmacol Sci· April 2024

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Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs.
Hiroko Izumi-Nakaseko, Koki Chiba, Ai Goto, Ryuichi Kambayashi, Akio Matsumoto

Cardiovasc Toxicol· June 2023

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Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors.
Koki Chiba, Ryuichi Kambayashi, Mayu Onozato, Ai Goto, Hiroko Izumi-Nakaseko

J Pharmacol Sci· November 2022

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False Hypercortisolemia Due to Abnormal Albumin-Cortisol Binding in a Patient with Familial Dysalbuminemic Hyperthyroxinemia.
Koki Chiba, Hiraku Kameda, Aika Miya, Hiroshi Nomoto, Kyu Yong Cho

Thyroid· February 2022

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A Review on the Mechanism and Application of Keishibukuryogan.
Koichiro Tanaka, Koki Chiba, Kazuhiko Nara

Front Nutr· December 2021

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Effects of Cardiac Massage and β-Blocker Pretreatment on the Success Rate of Cardiopulmonary Resuscitation Assessed by the Canine Ischemia/Reperfusion-Induced Ventricular Fibrillation Model.
Takeshi Wada, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba

Circ J· September 2021

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In vivo characterization of anti-atrial fibrillatory potential and pharmacological safety profile of I plus I inhibitor ranolazine using the halothane-anesthetized dogs.
Yoshio Nunoi, Ryuichi Kambayashi, Ai Goto, Mihoko Hagiwara-Nagasawa, Koki Chiba

Heart Vessels· July 2021

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Effects of mechanical ventilation with expiratory negative airway pressure on porcine pulmonary and systemic circulation: mechano-physiology and potential application.
Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Takeshi Wada

J Physiol Sci· June 2021

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Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones.
Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Koki Chiba

Naunyn Schmiedebergs Arch Pharmacol· April 2021

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Translational Studies on Anti-Atrial Fibrillatory Action of Oseltamivir by its and Electropharmacological Analyses.
Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Ai Goto, Kazuya Tsurudome, Hironori Ohshiro, Koki Chiba

Front Pharmacol· April 2021

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Sodium-glucose cotransporter 2 inhibitors reduce day-to-day glucose variability in patients with type 1 diabetes.
Koki Chiba, Hiroshi Nomoto, Akinobu Nakamura, Kyu Yong Cho, Kumiko Yamashita

J Diabetes Investig· February 2021

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Analysis of electropharmacological effects of AVE0118 on the atria of chronic atrioventricular block dogs: characterization of anti-atrial fibrillatory action by atrial repolarization-delaying agent.
Ryuichi Kambayashi, Mihoko Hagiwara-Nagasawa, Tomoaki Ichikawa, Ai Goto, Koki Chiba

Heart Vessels· September 2020

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Optimizing the Direction and Order of the Motion Unveiled the Ability of Conventional Monolayers of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Show Frequency-Dependent Enhancement of Contraction and Relaxation Motion.
Hiroko Izumi-Nakaseko, Koki Chiba, Mihoko Hagiwara-Nagasawa, Ayano Satsuka, Ai Goto

Front Cell Dev Biol· September 2020

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How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone.
Ryuichi Kambayashi, Mihoko Hagiwara-Nagasawa, Yoshiki Kondo, Zhi Jie Yeo, Ai Goto, Koki Chiba

Cardiovasc Toxicol· August 2020

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Electropharmacological Characterization of Aciclovir in the Halothane-Anesthetized Dogs: A Proposal of Evaluation Method for Cardiovascular Safety Pharmacology of Anti-virus Drugs.
Yoshiki Kondo, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba

Cardiovasc Toxicol· August 2020

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Risperidone alone did not induce torsade de pointes: Experimental evidence from the chronic atrioventricular block model dogs.
Yoshio Nunoi, Koki Chiba, Mihoko Hagiwara-Nagasawa, Ai Goto, Ryuichi Kambayashi

J Pharmacol Sci· August 2020

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In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys.
Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba

J Pharmacol Sci· August 2020

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Characterization of microminipig as a laboratory animal for pharmacological study by analyzing bepridil-induced cardiovascular responses.
Yoshio Nunoi, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba

J Pharmacol Sci· May 2020

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Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin-dopamine antagonists against insomnia and nocturnal delirium.
Ryuichi Kambayashi, Mihoko Hagiwara-Nagasawa, Ai Goto, Koki Chiba, Hiroko Izumi-Nakaseko

Heart Vessels· April 2020

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Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes.
Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba

J Pharmacol Sci· April 2020

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Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors.
Hiroko Izumi-Nakaseko, Masachika Fujiyoshi, Mihoko Hagiwara-Nagasawa, Ai Goto, Koki Chiba

Cardiovasc Toxicol· February 2020

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In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval.
Ryuichi Kambayashi, Mihoko Hagiwara-Nagasawa, Ai Goto, Koki Chiba, Hiroko Izumi-Nakaseko

J Vet Med Sci· December 2019

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Pharmacological β-adrenoceptor blockade can augment torsadogenic action of I inhibitor: Comparison of proarrhythmic effects of d-sotalol and dl-sotalol in the chronic atrioventricular block dogs.
Ai Goto, Mihoko Hagiwara-Nagasawa, Koki Chiba, Ryuichi Kambayashi, Yoshio Nunoi

J Pharmacol Sci· September 2019

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Analysis of electro-mechanical relationship in human iPS cell-derived cardiomyocytes sheets under proarrhythmic condition assessed by simultaneous field potential and motion vector recordings.
Atsushi Sugiyama, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba

J Pharmacol Sci· August 2019

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