Publications by authors named "Koko Asakura"

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Optimal Antithrombotics for Ischemic Stroke and Concurrent Atrial Fibrillation and Atherosclerosis: A Randomized Clinical Trial.
Shuhei Okazaki, Kanta Tanaka, Yukako Yazawa, Ryosuke Doijiri, Masatoshi Koga, Koko Asakura

JAMA Neurol· December 2025

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Taxifolin for prevention of COGnitive impairment (T-COG trial): a study protocol for a randomized, double-blind, placebo-controlled trial.
Tetsuya Chiba, Yorito Hattori, Koko Asakura, Yuka Sano, Satoshi Saito

Front Nutr· October 2025

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Phase 2 Study to Evaluate the Efficacy and Safety of Inhaled Nitric Oxide Therapy in Patients With Severe Right Heart Failure Associated With Pulmonary Hypertension　- Protocol for the PHiNO Study.
Jin Ueda, Akihiro Tsuji, Tatsuo Aoki, Ryotaro Asano, Takatoyo Kiko, Koko Asakura

Circ Rep· April 2025

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Pulmonary Artery Denervation for Medication Refractory Pulmonary Hypertension (PARPH Study)　- Study Protocol for a Prospective, Open-Label, Single-Arm Clinical Trial.
Ryotaro Asano, Satoshi Nagase, Tatsuo Aoki, Jin Ueda, Akihiro Tsuji, Koko Asakura

Circ Rep· March 2025

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Effect of low-dose administration of carperitide for acute heart failure: the LASCAR-AHF trial.
Satoshi Honda, Toshiyuki Nagai, Yasuyuki Honda, Hiroki Nakano, Takanori Kawabata, Koko Asakura

Eur Heart J Acute Cardiovasc Care· February 2025

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Optimal antithrombotic therapy in ischemic stroke patients with non-valvular atrial fibrillation and atherothrombosis: study protocol for a randomized controlled trial.
Shuhei Okazaki, Haruko Yamamoto, Koko Asakura, Katsuhiro Omae, Hirotada Maeda

Front Neurol· October 2024

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Magnetic Resonance Imaging-Guided Intravenous Thrombolysis in Cardioembolic Stroke Patients With Unknown Time of Onset　- Subanalysis of the THAWS Randomized Control Trial.
Naoya Yamazaki, Masatoshi Koga, Ryosuke Doijiri, Manabu Inoue, Kaori Miwa, Koko Asakura

Circ J· February 2024

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Metabolic syndrome is linked to the incidence of pancreatic cancer.
Yohei Miyashita, Tatsuro Hitsumoto, Hiroki Fukuda, Jiyoong Kim, Shin Ito, Koko Asakura

EClinicalMedicine· January 2024

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Intravenous Alteplase at 0.6 mg/kg for Unknown Onset Stroke with Prior Antithrombotic Medication: THAWS Randomized Clinical Trial.
Masatoshi Koga, Manabu Inoue, Kaori Miwa, Sohei Yoshimura, Mayumi Fukuda-Doi, Koko Asakura

J Atheroscler Thromb· January 2023

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Cerebral microbleeds development after stroke thrombolysis: A secondary analysis of the THAWS randomized clinical trial.
Kaori Miwa, Masatoshi Koga, Manabu Inoue, Sohei Yoshimura, Makoto Sasaki, Koko Asakura

Int J Stroke· July 2022

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Impact of cascade screening for catecholaminergic polymorphic ventricular tachycardia type 1.
Keiko Shimamoto, Seiko Ohno, Koichi Kato, Koichiro Takayama, Keiko Sonoda, Koko Asakura

Heart· May 2022

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Magnetic Resonance Imaging-Guided Thrombolysis (0.6 mg/kg) Was Beneficial for Unknown Onset Stroke Above a Certain Core Size: THAWS RCT Substudy.
Kazunori Toyoda, Manabu Inoue, Sohei Yoshimura, Hiroshi Yamagami, Makoto Sasaki, Koko Asakura

Stroke· January 2021

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"BAX602" in Preventing Surgical Adhesion after Extracorporeal Ventricular Assist Device Implantation for Refractory Congestive Heart Failure: Study Protocol for a Multicenter Randomized Clinical Trial.
Satsuki Fukushima, Koko Asakura, Toshimitsu Hamasaki, Kaori Onda, Takuya Watanabe

Cardiovasc Drugs Ther· October 2020

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Rationale and Design of a Prospective, Multicenter, Single-Arm Clinical Trial to Investigate the Safety and Effectiveness of Rotablator Atherectomy System as an Adjunctive Device for Endovascular Treatment of Occlusive Atherosclerotic Lesions in Below-the-Knee Arteries With Critical Limb Ischemia (RESCUE-BTK).
Takeshi Yagyu, Shin Ito, Osami Kawarada, Mitsuyo Mizuseki, Haruko Yamamoto, Masanori Asakura, Koko Asakura

Circ Rep· June 2020

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Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: A Randomized Controlled Trial.
Masatoshi Koga, Haruko Yamamoto, Manabu Inoue, Koko Asakura, Junya Aoki

Stroke· May 2020

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Interim Monitoring for Futility in Clinical Trials with Two Co-primary Endpoints Using Prediction.
Koko Asakura, Scott R Evans, Toshimitsu Hamasaki

Stat Biopharm Res· November 2019

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Design, data monitoring, and analysis of clinical trials with co-primary endpoints: A review.
Toshimitsu Hamasaki, Scott R Evans, Koko Asakura

J Biopharm Stat· July 2019

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Japanese Antibacterial Drug Management for Cardiac Sarcoidosis (J-ACNES): A multicenter, open-label, randomized, controlled study.
Kohei Ishibashi, Yoshinobu Eishi, Nobuhiro Tahara, Masanori Asakura, Naka Sakamoto, Koko Asakura

J Arrhythm· October 2018

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Functional mitral stenosis after mitral valve repair for Type II dysfunction: determinants and impacts on long-term outcome.
Naonori Kawamoto, Tomoyuki Fujita, Satsuki Fukushima, Yusuke Shimahara, Yuta Kume, Koko Asakura

Eur J Cardiothorac Surg· September 2018

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Group-sequential three-arm noninferiority clinical trial designs.
Toshimitsu Ochiai, Toshimitsu Hamasaki, Scott R Evans, Koko Asakura, Yuko Ohno

J Biopharm Stat· January 2018

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Should annuloplasty prosthesis be selected dependent on the location of prolapse in mitral valve repair for type II dysfunction?
Naonori Kawamoto, Tomoyuki Fujita, Satsuki Fukushima, Hiroki Hata, Yusuke Shimahara, Koko Asakura

J Thorac Cardiovasc Surg· December 2017

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Arrhythmia risk and β-blocker therapy in pregnant women with long QT syndrome.
Kohei Ishibashi, Takeshi Aiba, Chizuko Kamiya, Aya Miyazaki, Heima Sakaguchi, Koko Asakura

Heart· September 2017

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Interim evaluation of efficacy or futility in group-sequential trials with multiple co-primary endpoints.
Koko Asakura, Toshimitsu Hamasaki, Scott R Evans

Biom J· July 2017

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Sample Size Considerations in Clinical Trials when Comparing Two Interventions using Multiple Co-Primary Binary Relative Risk Contrasts.
Yuki Ando, Toshimitsu Hamasaki, Scott R Evans, Koko Asakura, Tomoyuki Sugimoto

Stat Biopharm Res· June 2015

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Group-Sequential Strategies in Clinical Trials with Multiple Co-Primary Outcomes.
Toshimitsu Hamasaki, Koko Asakura, Scott R Evans, Tomoyuki Sugimoto, Takashi Sozu

Stat Biopharm Res· January 2015

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