Publications by authors named "Konstantin Helmsauer"

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Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers.
Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon, Elias Rodriguez-Fos, Konstantin Helmsauer

Cancer Discov· October 2025

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Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy.
Laura Grunewald, Lena Andersch, Konstantin Helmsauer, Silke Schwiebert, Anika Klaus

Pharmacol Res· February 2025

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Reconstructing extrachromosomal DNA structural heterogeneity from long-read sequencing data using Decoil.
Mădălina Giurgiu, Nadine Wittstruck, Elias Rodriguez-Fos, Rocío Chamorro González, Lotte Brückner, Konstantin Helmsauer

Genome Res· October 2024

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Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.
Steffen Fuchs, Clara Danßmann, Filippos Klironomos, Annika Winkler, Jörg Fallmann, Konstantin Helmsauer

Nat Commun· July 2023

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Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Rocío Chamorro González, Thomas Conrad, Maja C Stöber, Robin Xu, Mădălina Giurgiu, Konstantin Helmsauer

Nat Genet· May 2023

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Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.
Heathcliff Dorado García, Fabian Pusch, Yi Bei, Jennifer von Stebut, Glorymar Ibáñez, Konstantin Helmsauer

Nat Commun· July 2022

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ecDNA hubs drive cooperative intermolecular oncogene expression.
King L Hung, Kathryn E Yost, Liangqi Xie, Quanming Shi, Konstantin Helmsauer

Nature· December 2021

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Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Konstantin Helmsauer, Maria E Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin

Nat Commun· November 2020

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Publisher Correction: Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Richard P Koche, Elias Rodriguez-Fos, Konstantin Helmsauer, Martin Burkert, Ian C MacArthur

Nat Genet· April 2020

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Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Richard P Koche, Elias Rodriguez-Fos, Konstantin Helmsauer, Martin Burkert, Ian C MacArthur

Nat Genet· January 2020

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