Publications by authors named "Konstantin Khrapko"

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Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells.
Kelly McCastlain, Catherine Welsh, Yonghui Ni, Liang Ding, Ti-Cheng Chang, Konstantin Khrapko

Sci Adv· September 2025

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Deciphering the Foundations of Mitochondrial Mutational Spectra: Replication-Driven and Damage-Induced Signatures Across Chordate Classes.
Dmitrii Iliushchenko, Bogdan Efimenko, Alina G Mikhailova, Victor Shamanskiy, Murat K Saparbaev, Konstantin Khrapko

Mol Biol Evol· February 2025

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Somatic mitochondrial DNA mutations are a source of heterogeneity among primary leukemic cells.
Kelly McCastlain, Catherine Welsh, Yonghui Ni, Liang Ding, Melissa Franco, Konstantin Khrapko

medRxiv· September 2024

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Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive.
Zoë Fleischmann, Auden Cote-L'Heureux, Melissa Franco, Sergey Oreshkov, Sofia Annis, Mark Khrapko, Konstantin Khrapko

Mitochondrion· January 2024

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Interpreting Sequence-Levenshtein distance for determining error type and frequency between two embedded sequences of equal length.
Robert Logan, Amy Wangsness Wehe, Dori C Woods, Jon Tilly, Konstantin Khrapko

ArXiv· October 2023

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Secondary structure of the human mitochondrial genome affects formation of deletions.
Victor Shamanskiy, Alina A Mikhailova, Evgenii O Tretiakov, Kristina Ushakova, Alina G Mikhailova, Konstantin Khrapko

BMC Biol· May 2023

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Are some mutations more equal than others?
Auden Cote-L'Heureux, Yogesh N K Maithania, Melissa Franco, Konstantin Khrapko

Elife· April 2023

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Dynamics of the most common pathogenic mtDNA variant m.3243A > G demonstrate frequency-dependency in blood and positive selection in the germline.
Melissa Franco, Sarah J Pickett, Zoe Fleischmann, Mark Khrapko, Auden Cote-L'Heureux, Konstantin Khrapko

Hum Mol Genet· November 2022

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A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand.
Alina G Mikhailova, Alina A Mikhailova, Kristina Ushakova, Evgeny O Tretiakov, Dmitrii Iliushchenko, Konstantin Khrapko

Nucleic Acids Res· October 2022

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Mitochondrial Pseudogenes Suggest Repeated Inter-Species Hybridization among Direct Human Ancestors.
Konstantin Popadin, Konstantin Gunbin, Leonid Peshkin, Sofia Annis, Zoe Fleischmann, Konstantin Khrapko

Genes (Basel)· May 2022

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3GOLD: optimized Levenshtein distance for clustering third-generation sequencing data.
Robert Logan, Zoe Fleischmann, Sofia Annis, Amy Wangsness Wehe, Jonathan L Tilly, Konstantin Khrapko

BMC Bioinformatics· March 2022

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Retraction Note to: Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice.
Adeel Safdar, Konstantin Khrapko, James M Flynn, Ayesha Saleem, Michael De Lisio

Skelet Muscle· March 2021

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A nanoscale, multi-parametric flow cytometry-based platform to study mitochondrial heterogeneity and mitochondrial DNA dynamics.
Julie A MacDonald, Alisha M Bothun, Sofia N Annis, Hannah Sheehan, Somak Ray, Konstantin Khrapko

Commun Biol· May 2020

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LUCS: a high-resolution nucleic acid sequencing tool for accurate long-read analysis of individual DNA molecules.
Sofia Annis, Zoë Fleischmann, Robert Logan, Zachary Mullin-Bernstein, Melissa Franco, Konstantin Khrapko

Aging (Albany NY)· April 2020

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Quasi-Mendelian paternal inheritance of mitochondrial DNA: A notorious artifact, or anticipated behavior?
Sofia Annis, Zoe Fleischmann, Mark Khrapko, Melissa Franco, Kevin Wasko, Konstantin Khrapko

Proc Natl Acad Sci U S A· July 2019

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Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse.
Christine Faraci, Sofia Annis, Joyce Jin, Housaiyin Li, Konstantin Khrapko

Reproduction· August 2018

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Influence of Maternal Aging on Mitochondrial Heterogeneity, Inheritance, and Function in Oocytes and Preimplantation Embryos.
Dori C Woods, Konstantin Khrapko, Jonathan L Tilly

Genes (Basel)· May 2018

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Data on the time of integration of the human mitochondrial pseudogenes (NUMTs) into the nuclear genome.
Konstantin Gunbin, Leonid Peshkin, Konstantin Popadin, Sofia Annis, Rebecca R Ackermann, Konstantin Khrapko

Data Brief· August 2017

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Integration of mtDNA pseudogenes into the nuclear genome coincides with speciation of the human genus. A hypothesis.
Konstantin Gunbin, Leonid Peshkin, Konstantin Popadin, Sofia Annis, Rebecca R Ackermann, Konstantin Khrapko

Mitochondrion· May 2017

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Quantitation of Mitochondrial DNA Deletions Via Restriction Digestion/Long-Range Single-Molecule PCR.
Yevgenya Kraytsberg, Xinhong Guo, Saisai Tao, Alexandra Kuznetsov, Catherine MacLean, Konstantin Khrapko

Methods Mol Biol· September 2016

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Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice.
Adeel Safdar, Konstantin Khrapko, James M Flynn, Ayesha Saleem, Michael De Lisio

Skelet Muscle· September 2016

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Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis.
Adeel Safdar, Sofia Annis, Yevgenya Kraytsberg, Chloe Laverack, Ayesha Saleem, Konstantin Khrapko

Curr Opin Genet Dev· June 2016

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ERRATUM TO: Quantitation of Mitochondrial DNA Deletions Via Restriction Digestion/Long-Range Single-Molecule PCR.
Yevgenya Kraytsberg, Xinhong Guo, Saisai Tao, Alexandra Kuznetsov, Catherine MacLean, Konstantin Khrapko

Methods Mol Biol· May 2016

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Modeling the aging heart: from local respiratory defects to global rhythm disturbances.
Konstantin Khrapko, Natalia Trayanova, Stanley Nattel

Cell Metab· May 2015

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Mitochondrial DNA mutations and cancer: lessons from the parathyroid.
Konstantin Popadin, Konstantin V Gunbin, Konstantin Khrapko

Am J Pathol· November 2014

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