Publications by authors named "Konstantin Tsoyi"

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Macropinocytosis inhibition attenuates pro-fibrotic responses in lung fibroblasts and pulmonary fibrosis.
Ivan O Rosas, Aaron K McDowell-Sanchez, Santiago Sanchez, Juan D Cala-Garcia, Alan R Waich Cohen, Konstantin Tsoyi

bioRxiv· July 2025

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Single cell transcriptomics in a treatment-segregated cohort exposes a STAT3-regulated therapeutic gap in idiopathic pulmonary fibrosis.
Neil J McKenna, Scott A Ochsner, Alan Waich, Juan Cala-Garcia, Maria E Ruiz Echartrea, Konstantin Tsoyi

bioRxiv· June 2025

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Osteoprotegerin is induced by transforming growth factor-beta 1 and regulates pro-fibrotic responses in human dermal fibroblasts.
Aaron K McDowell-Sanchez, Alan R Waich Cohen, Santiago Sanchez, Konstantin Tsoyi

Biochem Biophys Res Commun· March 2025

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QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age-related macular degeneration.
Samantha Arokiasamy, Michaela J M Balderstone, Faheem Shaik, Enrico Cristante, Thomas C Moseley, Konstantin Tsoyi

Br J Pharmacol· February 2025

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Skewed adaptive immune responses are involved in alpha-1 antitrypsin deficiency emphysema.
Joselyn Rojas-Quintero, Scott A Ochsner, Hyun-Sung Lee, Christine Cong, Alan Waich Cohen, Konstantin Tsoyi

Eur Respir J· January 2025

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PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation.
Santiago Sanchez, Aaron K McDowell-Sanchez, Sharaz B Al-Meerani, Juan D Cala-Garcia, Alan R Waich Cohen, Konstantin Tsoyi

PLoS One· September 2024

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Fibroblast heterogeneity in pulmonary fibrosis: a new target for therapeutics development?
Konstantin Tsoyi, Ivan O Rosas

Eur Respir J· February 2024

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Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA.
Benjamin Geary, Bo Sun, Ronak R Tilvawala, Leonard Barasa, Konstantin Tsoyi

Front Immunol· December 2023

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SHP2 promotes sarcoidosis severity by inhibiting SKP2-targeted ubiquitination of TBET in CD8 T cells.
Sherly I Celada, Clarice X Lim, Alexandre F Carisey, Scott A Ochsner, Carlos F Arce Deza, Konstantin Tsoyi

Sci Transl Med· September 2023

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Targeting Danger Signals to Rescue Fibrosis.
Konstantin Tsoyi, Ivan O Rosas

Am J Respir Cell Mol Biol· May 2022

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Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
Konstantin Tsoyi, Anthony J Esposito, Bo Sun, Ryan G Bowen, Kevin Xiong

Sci Rep· February 2022

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Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation.
Junwen Han, Yuanyuan Shi, Gareth Willis, Jewel Imani, Min-Young Kwon, Konstantin Tsoyi

FEBS J· January 2022

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CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
Konstantin Tsoyi, Xiaoliang Liang, Giulia De Rossi, Stefan W Ryter, Kevin Xiong

Am J Respir Crit Care Med· August 2021

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PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis.
Bo Sun, Beverly Tomita, Ari Salinger, Ronak R Tilvawala, Ling Li, Konstantin Tsoyi

Matrix Biol· August 2021

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Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models.
Suraj U Hettiarachchi, Yen-Hsing Li, Jyoti Roy, Fenghua Zhang, Estela Puchulu-Campanella, Konstantin Tsoyi

Sci Transl Med· October 2020

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Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis.
Fenghua Zhang, Ehab A Ayaub, Bingbing Wang, Estela Puchulu-Campanella, Yen-Hsing Li, Konstantin Tsoyi

EMBO Mol Med· August 2020

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Expression of Stromal Cell-Derived Factor-1 by Mesenchymal Stromal Cells Impacts Neutrophil Function During Sepsis.
Min-Young Kwon, Sailaja Ghanta, Julie Ng, Konstantin Tsoyi, James A Lederer

Crit Care Med· May 2020

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Biobanking and cryopreservation of human lung explants for omic analysis.
Sarah G Chu, Sergio Poli De Frias, Yuichi Sakairi, Rachel S Kelly, Robert Chase, Konstantin Tsoyi

Eur Respir J· January 2020

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Palmitic Acid-Rich High-Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress.
Sarah G Chu, Julian A Villalba, Xiaoliang Liang, Kevin Xiong, Konstantin Tsoyi

Am J Respir Cell Mol Biol· December 2019

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Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness.
Konstantin Tsoyi, Juan C Osorio, Sarah G Chu, Isis E Fernandez, Sergio Poli De Frias

Am J Respir Cell Mol Biol· June 2019

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Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148.
Konstantin Tsoyi, Sarah G Chu, Nasly G Patino-Jaramillo, Julie Wilder, Julian Villalba

Am J Respir Cell Mol Biol· February 2018

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Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.
Sailaja Ghanta, Konstantin Tsoyi, Xiaoli Liu, Kiichi Nakahira, Bonna Ith

Am J Respir Cell Mol Biol· March 2017

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Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators.
Konstantin Tsoyi, Sean R R Hall, Jesmond Dalli, Romain A Colas, Sailaja Ghanta

Crit Care Med· December 2016

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Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages.
Konstantin Tsoyi, Adriana M Geldart, Helen Christou, Xiaoli Liu, Su Wol Chung

J Leukoc Biol· January 2015

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CKD712, a synthetic isoquinoline alkaloid, enhances the anti-cancer effects of paclitaxel in MDA-MB-231 cells through regulation of PTEN.
Young Min Kim, Konstantin Tsoyi, Hwa Jin Jang, Eun Jung Park, Sang Won Park

Life Sci· September 2014

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