Publications by authors named "Kosuke Otani"

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A selective eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood glucose in Zucker fatty diabetes mellitus rat.
Ko Adachi, Tomoko Kodama, Kosuke Otani, Keito Sano, Asuka Sugiyama

J Pharmacol Sci· July 2025

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Senescent cardiac fibroblasts-derived extracellular vesicles induced autophagy in cardiac fibroblasts via suppression of ras homolog enriched in brain like 1.
Yusei Fujioka, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

J Pharmacol Sci· May 2025

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Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury.
Hayato Sasaki, Kazuki Otake, Kazuki Takeda, Karin Tesaki, Eiki Takahashi, Kosuke Otani

PLoS One· May 2025

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The eukaryotic elongation factor 2 kinase inhibitor, A484954, induces hypoglycaemic and hypotensive effects.
Tomoko Kodama, Satoshi Kameshima, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

Br J Pharmacol· April 2025

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Development of an Effective Isolation Method for Plasma Extracellular Vesicles Excluding Lipoproteins by Precipitation With Polyethylene Glycol.
Kosuke Otani, Yusei Fujioka, Muneyoshi Okada, Hideyuki Yamawaki

J Extracell Biol· April 2025

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Minocycline prevents monocrotaline-induced pulmonary hypertension through the attenuation of endothelial dysfunction and vascular wall thickening.
Ryo Niijima, Kosuke Otani, Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki

J Pharmacol Sci· January 2025

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Alteration of reactivity in isolated mesenteric artery from Zucker fatty diabetes mellitus rats.
Kosuke Otani, Naofumi Uemura, Hiroshi Funada, Tomoko Kodama, Muneyoshi Okada

J Pharmacol Sci· September 2024

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Human omentin-1 reduces vascular insulin resistance and hypertension in Otsuka Long-Evans Tokushima Fatty rats.
Yuta Okamura, Ko Adachi, Ryo Niijima, Tomoko Kodama, Kosuke Otani

Naunyn Schmiedebergs Arch Pharmacol· May 2024

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Eukaryotic elongation factor 2 kinase inhibitor, A484954 induced diuresis via nitric oxide production in spontaneously hypertensive rats.
Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

J Vet Med Sci· December 2023

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Autocrine role of senescent cardiac fibroblasts-derived extracellular vesicles.
Yusei Fujioka, Kosuke Otani, Tomoko Kodama, Muneyoshi Okada, Hideyuki Yamawaki

J Vet Med Sci· November 2023

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Human Omentin-1 Administration Ameliorates Hypertensive Complications without Affecting Hypertension in Spontaneously Hypertensive Rats.
Yuta Okamura, Ryo Niijima, Satoshi Kameshima, Tomoko Kodama, Kosuke Otani

Int J Mol Sci· February 2023

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Chemerin fragments show different effects on systemic blood pressure dependent on carboxyl-terminal cleavage site.
Atsunori Yamamoto, Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

J Vet Med Sci· September 2022

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Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits perivascular sympathetic nerve stimulation-induced vasoconstriction in isolated renal artery.
Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

Eur J Pharmacol· July 2022

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Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes.
Kosuke Otani, Hiroshi Funada, Risa Teranishi, Muneyoshi Okada, Hideyuki Yamawaki

Int J Mol Sci· April 2022

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Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro.
Atsunori Yamamoto, Ayumi Sagara, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

Eur J Pharmacol· December 2021

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Eukaryotic elongation factor 2 kinase inhibitor, A484954 induces diuretic effect via renal vasorelaxation in spontaneously hypertensive rats.
Tomoko Kodama, Satoshi Kameshima, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

Eur J Pharmacol· December 2021

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Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension.
Atsunori Yamamoto, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

Int J Mol Sci· October 2021

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[Development of basic research toward clinical application of cleaved fragment of type IV collagen].
Akira Sugiyama, Muneyoshi Okada, Kosuke Otani, Hideyuki Yamawaki

Nihon Yakurigaku Zasshi· September 2021

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A single injection of periostin decreases cardiac voltage-gated Na channel in rat ventricles.
Keisuke Imoto, Yuho Sakai, Muneyoshi Okada, Kosuke Otani, Hideyuki Yamawaki

J Vet Med Sci· July 2021

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Age-dependent increase in activity of eukaryotic elongation factor 2 kinase in mesenteric arteries from spontaneously hypertensive rats.
Tomoko Kodama, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

J Vet Med Sci· January 2021

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Preventive Effect of Canstatin against Ventricular Arrhythmia Induced by Ischemia/Reperfusion Injury: A Pilot Study.
Akira Sugiyama, Yurie Shimizu, Muneyoshi Okada, Kosuke Otani, Hideyuki Yamawaki

Int J Mol Sci· January 2021

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Decreased Expression of Canstatin in Rat Model of Monocrotaline-Induced Pulmonary Arterial Hypertension: Protective Effect of Canstatin on Right Ventricular Remodeling.
Akira Sugiyama, Maina Kaisho, Muneyoshi Okada, Kosuke Otani, Hideyuki Yamawaki

Int J Mol Sci· September 2020

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Plasma small extracellular vesicles in hypertensive rats impair reactivity of isolated blood vessels.
Yusei Fujioka, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki

J Vet Med Sci· July 2020

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Small extracellular vesicles from rat plasma promote migration and proliferation of vascular smooth muscle cells.
Kosuke Otani, Mai Yokoya, Yusei Fujioka, Muneyoshi Okada, Hideyuki Yamawaki

J Vet Med Sci· March 2020

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Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats.
Ayaho Omori, Makoto Goshima, Chiharu Kakuda, Tomoko Kodama, Kosuke Otani

Pflugers Arch· March 2020

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