Publications by authors named "Kosuke Yusa"

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Development of a Synthetic Lethality-Based Combination Therapy Using LIG1 and PARP Inhibitors for Prostate Cancer.
Masaru Tani, Koji Hatano, Yu Ishizuya, Toshiki Oka, Tomohiro Kanaki, Kosuke Yusa

Cancer Sci· December 2025

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Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis.
Malgorzata Gozdecka, Monika Dudek, Sean Wen, Muxin Gu, Richard J Stopforth, Kosuke Yusa

Nature· June 2025

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HVJ-E links Apolipoprotein d to antitumor effects.
Airi Ishibashi, Noriko Ohta, Yuko Uegaki, Hidefumi Suzuki, Katsuya Fukino, Kosuke Yusa

J Immunother Cancer· June 2025

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CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant.
Shunya Ikeda, Kana Hasegawa, Yosuke Kogue, Takao Arimori, Ryuhei Kawamoto, Kosuke Yusa

Nat Cancer· April 2025

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Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection.
Madoka Sakai, Yoshie Masuda, Yusuke Tarumoto, Naoyuki Aihara, Yugo Tsunoda, Kosuke Yusa

iScience· August 2024

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Genome-wide loss-of-function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus-integrated hepatoma cells.
Makoto Fukuoka, Takahiro Kodama, Kazuhiro Murai, Hayato Hikita, Emi Sometani, Kosuke Yusa

Cancer Sci· March 2024

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Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia.
Kazunari Aoki, Mizuki Hyuga, Yusuke Tarumoto, Gohei Nishibuchi, Atsushi Ueda, Kosuke Yusa

Blood· February 2024

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RENGE infers gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations.
Masato Ishikawa, Seiichi Sugino, Yoshie Masuda, Yusuke Tarumoto, Yusuke Seto, Kosuke Yusa

Commun Biol· December 2023

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S supports two steps of rubella virus life cycle.
Mayuko Yagi, Minami Hama, Sayaka Ichii, Yurie Nakashima, Daiki Kanbayashi, Kosuke Yusa

iScience· November 2023

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Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma.
Vincent W Keng, Amy P Chiu, Jeffrey C To, Xiao-Xiao Li, Michael A Linden, Kosuke Yusa

Heliyon· August 2023

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B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.
Daniel F Kaemena, Masahito Yoshihara, Meryam Beniazza, James Ashmore, Suling Zhao, Kosuke Yusa

Nat Commun· January 2023

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Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin.
Tomoyuki Abe, Yoshihito Horisawa, Osamu Kikuchi, Hitomi Ozawa-Umeta, Atsuhiro Kishimoto, Kosuke Yusa

Eur J Pharmacol· November 2022

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AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors.
Shanade Dunn, Cath Eberlein, Jason Yu, Albert Gris-Oliver, Swee Hoe Ong, Kosuke Yusa

Oncogene· November 2022

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Author Correction: Pooled extracellular receptor-ligand interaction screening using CRISPR activation.
Zheng-Shan Chong, Shuhei Ohnishi, Kosuke Yusa, Gavin J Wright

Genome Biol· October 2022

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Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming.
Amanda J Collier, Adam Bendall, Charlene Fabian, Andrew A Malcolm, Katarzyna Tilgner, Kosuke Yusa

Sci Adv· March 2022

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Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.
Kana Hasegawa, Shunya Ikeda, Moto Yaga, Kouki Watanabe, Rika Urakawa, Kosuke Yusa

Sci Transl Med· February 2022

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The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.
Marina Lafage-Pochitaloff, Bastien Gerby, Véronique Baccini, Laetitia Largeaud, Vincent Fregona, Kosuke Yusa

Blood Adv· January 2022

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Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals.
Tomohiro Suzuki, Mayuko Hayashi, Tetsuro Komatsu, Akiko Tanioka, Masahiro Nagasawa, Kosuke Yusa

Endocr J· December 2021

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KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.
Yan Zi Au, Muxin Gu, Etienne De Braekeleer, Malgorzata Gozdecka, Demetrios Aspris, Kosuke Yusa

Leukemia· April 2021

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Minimal genome-wide human CRISPR-Cas9 library.
Emanuel Gonçalves, Mark Thomas, Fiona M Behan, Gabriele Picco, Clare Pacini, Kosuke Yusa

Genome Biol· January 2021

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Author Correction: ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response.
Sankari Nagarajan, Shalini V Rao, Joseph Sutton, Danya Cheeseman, Shanade Dunn, Kosuke Yusa

Nat Genet· March 2020

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Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions.
Oliver Thompson, Ferdinand von Meyenn, Zoe Hewitt, John Alexander, Andrew Wood, Kosuke Yusa

Nat Commun· March 2020

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ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response.
Sankari Nagarajan, Shalini V Rao, Joseph Sutton, Danya Cheeseman, Shanade Dunn, Kosuke Yusa

Nat Genet· February 2020

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Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets.
Joshua M Dempster, Clare Pacini, Sasha Pantel, Fiona M Behan, Thomas Green, Kosuke Yusa

Nat Commun· December 2019

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Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening.
Gabriele Picco, Elisabeth D Chen, Luz Garcia Alonso, Fiona M Behan, Emanuel Gonçalves, Kosuke Yusa

Nat Commun· May 2019

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