Publications by authors named "Kotaro Hama"

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A sensitive LC-MS/MS method for quantifying phosphatidic acid species using basic mobile phases.
Kotaro Hama, Shohei Azuma, Yuko Fujiwara, Ayako Watanabe, Koko Imai

Biochem Biophys Res Commun· January 2026

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Phosphatidylcholine with C26:0-moiety, a precursor of a diagnostic marker for X-ALD, is synthesized by LPLAT10/LPEAT2.
Kotaro Hama, Yuko Fujiwara, Koko Imai, Yoshio Kusakabe, Yasuhiro Hayashi

J Lipid Res· December 2025

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Elaidic acid drives cellular senescence and inflammation via lipid raft-mediated IL-1R signaling.
Ryota Kojima, Yusuke Hirata, Ryo Ashida, Miki Takahashi, Ryosuke Matsui, Kotaro Hama

iScience· September 2025

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Mycobacterium leprae promotes triacylglycerol de novo synthesis through induction of GPAT3 expression in human premonocytic THP-1 cells.
Kazunari Tanigawa, Yasuhiro Hayashi, Kotaro Hama, Atsushi Yamashita, Kazuaki Yokoyama

PLoS One· July 2024

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Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer.
Tamuro Hayama, Kotaro Hama, Tsuyoshi Ozawa, Yuko Fujiwara, Keijiro Nozawa

Sci Rep· September 2023

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Cathepsin G-induced malignant progression of MCF-7 cells involves suppression of PAF signaling through induced expression of PAFAH1B2.
Kazunari Tanigawa, Mitsuo Kiriya, Yasuhiro Hayashi, Yoshiaki Shinden, Yuko Kijima, Kotaro Hama

Biochim Biophys Acta Mol Cell Biol Lipids· August 2022

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Controlled Tetradeuteration of Straight-Chain Fatty Acids: Synthesis, Application, and Insight into the Metabolism of Oxidized Linoleic Acid.
Ayako Watanabe, Kotaro Hama, Kohei Watanabe, Yuko Fujiwara, Kazuaki Yokoyama

Angew Chem Int Ed Engl· June 2022

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Development of a liquid chromatography-electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids.
Hyeon-Cheol Lee-Okada, Kotaro Hama, Kazuaki Yokoyama, Takehiko Yokomizo

J Biochem· October 2021

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-(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide Δ4-Desaturase 1-Independent Mechanism.
Yasuhiro Hayashi, Kiyoto Tsuchiya, Mizuki Yamamoto, Yoko Nemoto-Sasaki, Kazunari Tanigawa, Kotaro Hama

J Virol· August 2021

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Glycosphingolipids with Very Long-Chain Fatty Acids Accumulate in Fibroblasts from Adrenoleukodystrophy Patients.
Yuko Fujiwara, Kotaro Hama, Nobuyuki Shimozawa, Kazuaki Yokoyama

Int J Mol Sci· August 2021

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Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues.
Kotaro Hama, Yuko Fujiwara, Tamuro Hayama, Tsuyoshi Ozawa, Keijiro Nozawa

Sci Rep· March 2021

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Hexacosenoyl-CoA is the most abundant very long-chain acyl-CoA in ATP binding cassette transporter D1-deficient cells.
Kotaro Hama, Yuko Fujiwara, Shigeo Takashima, Yasuhiro Hayashi, Atsushi Yamashita

J Lipid Res· April 2020

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Mass spectrometry in combination with a chiral column and multichannel-MRM allows comprehensive analysis of glycosphingolipid molecular species from mouse brain.
Yuko Fujiwara, Kotaro Hama, Kazuaki Yokoyama

Carbohydr Res· April 2020

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Identification of Potent Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain.
Mitsuyasu Kawaguchi, Takayoshi Okabe, Shinichi Okudaira, Kotaro Hama, Kuniyuki Kano

J Med Chem· March 2020

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Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels.
Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Naoki Matsumoto, Kotaro Hama, Takashi Tanikawa

J Biol Chem· November 2018

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Acyl Chain Preference in Foam Cell Formation from Mouse Peritoneal Macrophages.
Yuko Fujiwara, Kotaro Hama, Makoto Tsukahara, Ryosuke Izumi-Tsuzuki, Toru Nagai

Biol Pharm Bull· August 2018

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Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species.
Kotaro Hama, Yuko Fujiwara, Kazuaki Yokoyama

J Vis Exp· May 2018

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Profiling and Imaging of Phospholipids in Brains of Abcd1-Deficient Mice.
Kotaro Hama, Yuko Fujiwara, Masashi Morita, Fumiyoshi Yamazaki, Yuko Nakashima

Lipids· January 2018

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Comprehensive Quantitation Using Two Stable Isotopically Labeled Species and Direct Detection of N-Acyl Moiety of Sphingomyelin.
Kotaro Hama, Yuko Fujiwara, Hidetsugu Tabata, Hideyo Takahashi, Kazuaki Yokoyama

Lipids· September 2017

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ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation.
Tatsuji Nishioka, Naoaki Arima, Kuniyuki Kano, Kotaro Hama, Eriko Itai

Sci Rep· March 2016

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Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo.
Keita Nakanaga, Kotaro Hama, Kuniyuki Kano, Takanao Sato, Hiroshi Yukiura

J Biochem· April 2014

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Molecular species of phospholipids with very long chain fatty acids in skin fibroblasts of Zellweger syndrome.
Kotaro Hama, Toru Nagai, Chiho Nishizawa, Kazutaka Ikeda, Masashi Morita

Lipids· December 2013

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Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry.
Daisuke Saigusa, Kanako Shiba, Asuka Inoue, Kotaro Hama, Michiyo Okutani

Anal Bioanal Chem· June 2012

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Identification and biochemical characterization of a novel autotaxin isoform, ATXδ, with a four-amino acid deletion.
Takafumi Hashimoto, Shinichi Okudaira, Koji Igarashi, Kotaro Hama, Yutaka Yatomi

J Biochem· January 2012

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Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish.
Hiroshi Yukiura, Kotaro Hama, Keita Nakanaga, Masayuki Tanaka, Yoichi Asaoka

J Biol Chem· December 2011

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