Publications by authors named "Kristin A Eckert"

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Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome.
Suzanne E Hile, Matthias H Weissensteiner, Kara G Pytko, Joseph Dahl, Eduard Kejnovsky, Kristin A Eckert

Nucleic Acids Res· April 2025

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DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion.
Mili Das, Suzanne E Hile, Jennifer Brewster, Jan Leendert Boer, Rachel Bezalel-Buch, Kristin A Eckert

Nucleic Acids Res· January 2025

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Replication of [AT/TA] Microsatellite Sequences by Human DNA Polymerase δ Holoenzymes Is Dependent on dNTP and RPA Levels.
Kara G Pytko, Rachel L Dannenberg, Kristin A Eckert, Mark Hedglin

Biochemistry· April 2024

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Replication of [AT/TA] microsatellite sequences by human DNA polymerase δ holoenzymes is dependent on dNTP and RPA levels.
Kara G Pytko, Rachel L Dannenberg, Kristin A Eckert, Mark Hedglin

bioRxiv· November 2023

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Accurate sequencing of DNA motifs able to form alternative (non-B) structures.
Matthias H Weissensteiner, Marzia A Cremona, Wilfried M Guiblet, Nicholas Stoler, Robert S Harris, Kristin A Eckert

Genome Res· June 2023

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Special Issue "DNA Replication/Repair, and the DNA Damage Response in Human Disease".
Dong Zhang, Kristin A Eckert, Marietta Y W T Lee

Genes (Basel)· April 2023

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Nontraditional Roles of DNA Polymerase Eta Support Genome Duplication and Stability.
Kristin A Eckert

Genes (Basel)· January 2023

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Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity.
MaryElizabeth Stein, Suzanne E Hile, Matthias H Weissensteiner, Marietta Lee, Sufang Zhang, Kristin A Eckert

DNA Repair (Amst)· November 2022

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Impact of G-Quadruplexes and Chronic Inflammation on Genome Instability: Additive Effects during Carcinogenesis.
MaryElizabeth Stein, Kristin A Eckert

Genes (Basel)· November 2021

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Overexpression of oncogenic H-Ras in hTERT-immortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion.
Wei-Chung Tsao, Raquel Buj, Katherine M Aird, Julia M Sidorova, Kristin A Eckert

PLoS One· October 2021

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Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome.
Wilfried M Guiblet, Michael DeGiorgio, Xiaoheng Cheng, Francesca Chiaromonte, Kristin A Eckert

Genome Res· July 2021

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Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.
Wilfried M Guiblet, Marzia A Cremona, Robert S Harris, Di Chen, Kristin A Eckert

Nucleic Acids Res· February 2021

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Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D.
Simran Kaushal, Charles E Wollmuth, Kohal Das, Suzanne E Hile, Samantha B Regan, Kristin A Eckert

Cell Rep· April 2019

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DNA polymerases as chemotherapy targets: promise and challenges.
Kristin A Eckert, Ryan P Barnes

Oncotarget· January 2019

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DNA Polymerase Eta Prevents Tumor Cell-Cycle Arrest and Cell Death during Recovery from Replication Stress.
Ryan P Barnes, Wei-Chung Tsao, George-Lucian Moldovan, Kristin A Eckert

Cancer Res· December 2018

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Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition.
Nishita Shastri, Yu-Chen Tsai, Suzanne Hile, Deondre Jordan, Barrett Powell, Kristin A Eckert

Mol Cell· October 2018

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Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress.
Wei-Chung Tsao, Kristin A Eckert

Int J Mol Sci· October 2018

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DNA polymerases eta and kappa exchange with the polymerase delta holoenzyme to complete common fragile site synthesis.
Ryan P Barnes, Suzanne E Hile, Marietta Y Lee, Kristin A Eckert

DNA Repair (Amst)· September 2017

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Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats.
Arkarachai Fungtammasan, Marta Tomaszkiewicz, Rebeca Campos-Sánchez, Kristin A Eckert, Michael DeGiorgio

Mol Biol Evol· October 2016

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Corrigendum: A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?
Arkarachai Fungtammasan, Erin Walsh, Francesca Chiaromonte, Kristin A Eckert, Kateryna D Makova

Genome Res· October 2016

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Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites.
Beverly A Baptiste, Kimberly D Jacob, Kristin A Eckert

DNA Repair (Amst)· May 2015

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Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins.
Thomas A Guilliam, Stanislaw K Jozwiakowski, Aaron Ehlinger, Ryan P Barnes, Sean G Rudd, Kristin A Eckert

Nucleic Acids Res· January 2015

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Interplay between DNA repair and inflammation, and the link to cancer.
Dawit Kidane, Wook Jin Chae, Jennifer Czochor, Kristin A Eckert, Peter M Glazer

Crit Rev Biochem Mol Biol· November 2014

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Microsatellite interruptions stabilize primate genomes and exist as population-specific single nucleotide polymorphisms within individual human genomes.
Guruprasad Ananda, Suzanne E Hile, Amanda Breski, Yanli Wang, Yogeshwar Kelkar, Kristin A Eckert

PLoS Genet· July 2014

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DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis.
Valérie Bergoglio, Anne-Sophie Boyer, Erin Walsh, Valeria Naim, Gaëlle Legube, Kristin A Eckert

J Cell Biol· April 2013

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