Publications by authors named "Kristopher A Sarosiek"

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BCL-2 inhibition in Waldenström macroglobulinaemia and marginal zone lymphoma.
Shayna Sarosiek, Uriel Suarez, Maria Fernandez-Turizo, Kristopher A Sarosiek, Jorge J Castillo

Br J Haematol· December 2025

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BCL-X Dependence is a Subtype Agnostic Actionable Feature of Difficult-to-Treat Kidney Cancers.
Tupa Basuroy, Treg Grubb, Ananthan Sadagopan, Xingping Qin, Kylee Madison, Kristopher A Sarosiek

bioRxiv· December 2025

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Regulation of inflammatory processes by caspases.
Manuel Beltrán-Visiedo, Ruth Soler-Agesta, Kristopher A Sarosiek, Douglas R Green, Lorenzo Galluzzi

Nat Rev Mol Cell Biol· November 2025

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BCL-xL dependency in chromophobe renal cell carcinoma.
Nadine Mahmoud, Xingping Qin, Wafaa Bzeih, Damir Khabibullin, Michel Alchoueiry, Kristopher A Sarosiek

Cancer Gene Ther· October 2025

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A molecular circuit regulates fate plasticity in emerging and adult AT2 cells.
Amitoj S Sawhney, Brian J Deskin, Junming Cai, Daniel Gibbard, Gibran Ali, Kristopher A Sarosiek

Nat Commun· October 2025

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De novo pyrimidine biosynthesis inhibition synergizes with BCL-X targeting in pancreatic cancer.
Huan Zhang, Naiara Santana-Codina, Qijia Yu, Clara Poupault, Claudia Campos, Kristopher A Sarosiek

Nat Commun· July 2025

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Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-X degradation to overcome cancer chemoresistance.
Xingping Qin, Adam Presser, Lissah Johnson, Yusuke Matoba, Brendan S Shay, Kristopher A Sarosiek

bioRxiv· June 2025

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A molecular circuit regulates fate plasticity in emerging and adult AT2 cells.
Amitoj S Sawhney, Brian J Deskin, Junming Cai, Daniel Gibbard, Gibran Ali, Kristopher A Sarosiek

bioRxiv· May 2025

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A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma.
Veronica Rendo, Eudocia Q Lee, Connor Bossi, Nicholas Khuu, Michelle A Rudek, Kristopher A Sarosiek

Sci Transl Med· February 2025

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Functional genomic screens with death rate analyses reveal mechanisms of drug action.
Megan E Honeywell, Marie S Isidor, Nicholas W Harper, Rachel E Fontana, Gavin A Birdsall, Kristopher A Sarosiek

Nat Chem Biol· November 2024

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Targeting Galectin 3 illuminates its contributions to the pathology of uterine serous carcinoma.
Yusuke Matoba, Dominique T Zarrella, Venkatesh Pooladanda, Maryam Azimi Mohammadabadi, Eugene Kim, Kristopher A Sarosiek

Br J Cancer· May 2024

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Inflammation and mitophagy are mitochondrial checkpoints to aging.
Emma Guilbaud, Kristopher A Sarosiek, Lorenzo Galluzzi

Nat Commun· April 2024

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In situ architecture of Opa1-dependent mitochondrial cristae remodeling.
Michelle Y Fry, Paula P Navarro, Pusparanee Hakim, Virly Y Ananda, Xingping Qin, Kristopher A Sarosiek

EMBO J· February 2024

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Role of intrinsic apoptosis in environmental exposure health outcomes.
Lissah Johnson, Kristopher A Sarosiek

Trends Mol Med· January 2024

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architecture of Opa1-dependent mitochondrial cristae remodeling.
Michelle Y Fry, Paula P Navarro, Pusparanee Hakim, Virly Y Ananda, Xingping Qin, Kristopher A Sarosiek

bioRxiv· November 2023

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Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX.
Rumani Singh, Stacey Yu, Marwa Osman, Zintis Inde, Cameron Fraser, Kristopher A Sarosiek

Cancer Res· October 2023

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Tuning ultrasmall theranostic nanoparticles for MRI contrast and radiation dose amplification.
Needa Brown, Paul Rocchi, Léna Carmès, Romy Guthier, Meghna Iyer, Kristopher A Sarosiek

Theranostics· October 2023

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p53 controls choice between apoptotic and non-apoptotic death following DNA damage.
Megan E Honeywell, Marie S Isidor, Nicholas W Harper, Rachel E Fontana, Peter Cruz-Gordillo, Kristopher A Sarosiek

bioRxiv· May 2023

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Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A Aaronson, John M Abrams, Kristopher A Sarosiek

Cell Death Differ· May 2023

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Targeting TBK1 to overcome resistance to cancer immunotherapy.
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Kristopher A Sarosiek

Nature· March 2023

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Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization.
Fiona Aguilar, Stacey Yu, Robert A Grant, Sebastian Swanson, Dia Ghose, Kristopher A Sarosiek

Structure· March 2023

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Endogenous and imposed determinants of apoptotic vulnerabilities in cancer.
Kristopher A Sarosiek, Kris C Wood

Trends Cancer· February 2023

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Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities.
Johan K E Spetz, Mary H C Florido, Cameron S Fraser, Xingping Qin, Jonathan Choiniere, Kristopher A Sarosiek

Sci Adv· November 2022

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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex.
Molly C McNamara, Aaron M Hosios, Margaret E Torrence, Ting Zhao, Cameron Fraser, Kristopher A Sarosiek

iScience· November 2022

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Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics.
Cameron S Fraser, Johan K E Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Shayna Sarosiek, Kristopher A Sarosiek

Nat Commun· October 2022

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