Publications by authors named "Krushna Patra"

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Generation of a Biliary Tract Cancer Cell Line Atlas Identifies Molecular Subtypes and Therapeutic Targets.
Vindhya Vijay, Negin Karisani, Lei Shi, Yu-Han Hung, Phuong Vu, Krushna C Patra

Cancer Discov· September 2025

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Correction: DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming.
Ilaria Gritti, Jinkai Wan, Vajira Weeresekara, Joel M Vaz, Giuseppe Tarantino, Krushna C Patra

Cancer Discov· April 2025

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DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming.
Ilaria Gritti, Jinkai Wan, Vajira Weeresekara, Joel M Vaz, Giuseppe Tarantino, Krushna C Patra

Cancer Discov· February 2025

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Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.
Megan E Bischoff, Behrouz Shamsaei, Juechen Yang, Dina Secic, Bhargav Vemuri, Krushna C Patra

Cancer Discov· February 2025

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Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma.
Megan E Bischoff, Behrouz Shamsaei, Juechen Yang, Dina Secic, Bhargav Vemuri, Krushna C Patra

bioRxiv· January 2024

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Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms.
Gary K L Chan, Samantha Maisel, Yeonjoo C Hwang, Bryan C Pascual, Rebecca R B Wolber, Krushna C Patra

Elife· January 2023

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A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis.
Catherine S Blaha, Gopalakrishnan Ramakrishnan, Sang-Min Jeon, Veronique Nogueira, Hyunsoo Rho, Krushna C Patra

Nat Commun· February 2022

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BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis.
Chrystelle L Vilfranc, Li-Xiao Che, Krushna C Patra, Liang Niu, Olugbenga Olowokure

World J Hepatol· March 2021

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REDD1 loss reprograms lipid metabolism to drive progression of mutant tumors.
Shuxi Qiao, Siang-Boon Koh, Varunika Vivekanandan, Devika Salunke, Krushna Chandra Patra

Genes Dev· June 2020

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TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma.
Lipika Goyal, Lei Shi, Leah Y Liu, Ferran Fece de la Cruz, Jochen K Lennerz, Krushna C Patra

Cancer Discov· August 2019

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EGFR Pathway Links Amino Acid Levels and Induction of Macropinocytosis.
Vajira K Weerasekara, Krushna C Patra, Nabeel Bardeesy

Dev Cell· August 2019

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AMPK-Mediated Lysosome Biogenesis in Lung Cancer Growth.
Krushna C Patra, Vajira K Weerasekara, Nabeel Bardeesy

Cell Metab· February 2019

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and Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma.
Margaret A Hill, William B Alexander, Bing Guo, Yasutaka Kato, Krushna Patra

Cancer Res· August 2018

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Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Krushna C Patra, Yasutaka Kato, Yusuke Mizukami, Sebastian Widholz, Myriam Boukhali

Nat Cell Biol· July 2018

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A Cell Size Theory of Aging.
Krushna C Patra, Nabeel Bardeesy

Dev Cell· June 2018

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Author Correction: Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
Dannielle DeWaal, Veronique Nogueira, Alexander R Terry, Krushna C Patra, Sang-Min Jeon

Nat Commun· June 2018

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Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation.
Veronique Nogueira, Krushna C Patra, Nissim Hay

Elife· April 2018

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Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
Dannielle DeWaal, Veronique Nogueira, Alexander R Terry, Krushna C Patra, Sang-Min Jeon

Nat Commun· January 2018

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Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm.
Krushna C Patra, Nabeel Bardeesy, Yusuke Mizukami

Clin Transl Gastroenterol· April 2017

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Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration.
Wan-Ni Yu, Veronique Nogueira, Arya Sobhakumari, Krushna C Patra, Prashanth T Bhaskar

Cell Rep· July 2015

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The pentose phosphate pathway and cancer.
Krushna C Patra, Nissim Hay

Trends Biochem Sci· August 2014

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Hexokinase 2 as oncotarget.
Krushna C Patra, Nissim Hay

Oncotarget· November 2013

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Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.
Krushna C Patra, Qi Wang, Prashanth T Bhaskar, Luke Miller, Zebin Wang

Cancer Cell· August 2013

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DDB2 suppresses epithelial-to-mesenchymal transition in colon cancer.
Nilotpal Roy, Prashant V Bommi, Uppoor G Bhat, Shaumick Bhattacharjee, Indira Elangovan, Krushna C Patra

Cancer Res· June 2013

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mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.
Prashanth T Bhaskar, Veronique Nogueira, Krushna C Patra, Sang-Min Jeon, Youngkyu Park

Mol Cell Biol· September 2009

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