Publications by authors named "Krysta Engel"

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Development of a Dynamic Counterfactual Risk Stratification Strategy for Newly Diagnosed Patients With AML Treated With Venetoclax and Azacitidine.
Nazmul Islam, Justin L Dale, Jamie S Reuben, Karan Sapiah, James W Coates, Krysta L Engel

JCO Clin Cancer Inform· December 2025

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Methyl-CpG-binding domain as a protein interaction partner in promoter regulation and neurodevelopment through evolutionary expanded entanglement.
Stephanie M Bilinovich, Surya B Chhetri, Jackson T Mitchell, Gage O Leighton, Vladislav Jdanov, Krysta L Engel

Am J Physiol Cell Physiol· September 2025

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SCUBA implements a storage format-agnostic API for single-cell data access in R.
William M Showers, Jairav Desai, Krysta L Engel, Clayton Smith, Craig T Jordan

F1000Res· August 2025

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scExploreR: a flexible platform for democratized analysis of multimodal single-cell data by non-programmers.
William M Showers, Jairav Desai, Stephanie R Gipson, Krysta L Engel, Clayton Smith

bioRxiv· June 2025

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Lysosomal acid lipase A modulates leukemia stem cell response to venetoclax/tyrosine kinase inhibitor combination therapy in blast phase chronic myeloid leukemia.
Mohd Minhajuddin, Amanda Winters, Haobin Ye, Shanshan Pei, Brett Stevens, Krysta Engel

Haematologica· January 2025

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Single-Cell RNA Sequencing before and after Light Chain Escape Reveals Intrapatient Multiple Myeloma Subpopulations with Divergent Osteolytic Gene Expression.
Denis Ohlstrom, Zachary J Walker, Abhishek Pandey, Lorraine N Davis, Krysta L Engel

Cancer Res Commun· January 2025

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Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium.
Anagha Inguva Sheth, Mark J Althoff, Hunter Tolison, Krysta Engel, Maria L Amaya

Cancer Discov· October 2024

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Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium.
Anagha Inguva Sheth, Krysta Engel, Hunter Tolison, Mark J Althoff, Maria L Amaya

bioRxiv· October 2023

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A Novel Type of Monocytic Leukemia Stem Cell Revealed by the Clinical Use of Venetoclax-Based Therapy.
Shanshan Pei, Ian T Shelton, Austin E Gillen, Brett M Stevens, Maura Gasparetto, Krysta Engel

Cancer Discov· September 2023

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Long-read sequencing and profiling of RNA-binding proteins reveals the pathogenic mechanism of aberrant splicing of an poison exon in epilepsy.
Hannah C Happ, Patricia N Schneider, Jung Hwa Hong, Eleanor Goes, Masha Bandouil, Krysta Engel

bioRxiv· May 2023

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Rate of transcription elongation and sequence-specific pausing by RNA polymerase I directly influence rRNA processing.
Abigail K Huffines, Krysta L Engel, Sarah L French, Yinfeng Zhang, Olga V Viktorovskaya

J Biol Chem· December 2022

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Systematic mutagenesis of TFIIH subunit p52/Tfb2 identifies residues required for XPB/Ssl2 subunit function and genetic interactions with TFB6.
Jacob Bassett, Jenna K Rimel, Shrabani Basu, Pratik Basnet, Jie Luo, Krysta L Engel

J Biol Chem· October 2022

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Machine Learning-Based Exploratory Clinical Decision Support for Newly Diagnosed Patients With Acute Myeloid Leukemia Treated With 7 + 3 Type Chemotherapy or Venetoclax/Azacitidine.
Nazmul Islam, Jamie S Reuben, Justin Dale, Jon Gutman, Christine M McMahon, Krysta Engel

JCO Clin Cancer Inform· September 2022

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Halo-seq: An RNA Proximity Labeling Method for the Isolation and Analysis of Subcellular RNA Populations.
Hei-Yong G Lo, Krysta L Engel, Raeann Goering, Ying Li, Robert C Spitale

Curr Protoc· May 2022

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Analysis of subcellular transcriptomes by RNA proximity labeling with Halo-seq.
Krysta L Engel, Hei-Yong G Lo, Raeann Goering, Ying Li, Robert C Spitale

Nucleic Acids Res· February 2022

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LABRAT reveals association of alternative polyadenylation with transcript localization, RNA binding protein expression, transcription speed, and cancer survival.
Raeann Goering, Krysta L Engel, Austin E Gillen, Nova Fong, David L Bentley

BMC Genomics· June 2021

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Mechanisms and consequences of subcellular RNA localization across diverse cell types.
Krysta L Engel, Ankita Arora, Raeann Goering, Hei-Yong G Lo, J Matthew Taliaferro

Traffic· June 2020

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NETSeq reveals heterogeneous nucleotide incorporation by RNA polymerase I.
Andrew M Clarke, Krysta L Engel, Keith E Giles, Chad M Petit, David A Schneider

Proc Natl Acad Sci U S A· December 2018

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Aberrant Inclusion of a Poison Exon Causes Dravet Syndrome and Related SCN1A-Associated Genetic Epilepsies.
Gemma L Carvill, Krysta L Engel, Aishwarya Ramamurthy, J Nicholas Cochran, Jolien Roovers

Am J Hum Genet· December 2018

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De novo mutations in MED13, a component of the Mediator complex, are associated with a novel neurodevelopmental disorder.
Lot Snijders Blok, Susan M Hiatt, Kevin M Bowling, Jeremy W Prokop, Krysta L Engel

Hum Genet· May 2018

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Direct Characterization of Transcription Elongation by RNA Polymerase I.
Suleyman Ucuncuoglu, Krysta L Engel, Prashant K Purohit, David D Dunlap, David A Schneider

PLoS One· July 2017

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Genomic diagnosis for children with intellectual disability and/or developmental delay.
Kevin M Bowling, Michelle L Thompson, Michelle D Amaral, Candice R Finnila, Susan M Hiatt, Krysta L Engel

Genome Med· May 2017

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Decoding transcriptional enhancers: Evolving from annotation to functional interpretation.
Krysta L Engel, Mark Mackiewicz, Andrew A Hardigan, Richard M Myers, Daniel Savic

Semin Cell Dev Biol· September 2016

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Spt6 Is Essential for rRNA Synthesis by RNA Polymerase I.
Krysta L Engel, Sarah L French, Olga V Viktorovskaya, Ann L Beyer, David A Schneider

Mol Cell Biol· July 2015

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Divergent contributions of conserved active site residues to transcription by eukaryotic RNA polymerases I and II.
Olga V Viktorovskaya, Krysta L Engel, Sarah L French, Ping Cui, Paul J Vandeventer

Cell Rep· September 2013

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