Publications by authors named "Krystian Pyta"

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New Structure Activity Relationship Insight into the Role of the C-3 Extension on Rifamycin Antimycobacterial Activity.
Clinton G L Veale, Ewelina Smolarz, Aleksandra Leśniewska, Krystian Pyta, Piotr Przybylski

ChemMedChem· November 2025

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Cascade Transformation of the Ansamycin Benzoquinone Core into Benzoxazole Influencing Anticancer Activity and Selectivity.
Natalia Skrzypczak, Krystian Pyta, Wiktor Bohusz, Aleksandra Leśniewska, Maria Gdaniec

J Org Chem· July 2023

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Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs.
Krystian Pyta, Natalia Skrzypczak, Piotr Ruszkowski, Franz Bartl, Piotr Przybylski

J Enzyme Inhib Med Chem· December 2022

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An Approach to Modify 14-Membered Lactone Macrolide Antibiotic Scaffolds.
Anna Janas, Krystian Pyta, Maria Gdaniec, Piotr Przybylski

J Org Chem· March 2022

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Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators.
Natalia Skrzypczak, Krystian Pyta, Piotr Ruszkowski, Przemysław Mikołajczak, Małgorzata Kucińska

J Enzyme Inhib Med Chem· December 2021

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Synthesis, structure and anticancer activity of new geldanamycin amine analogs containing C(17)- or C(20)- flexible and rigid arms as well as closed or open ansa-bridges.
Natalia Skrzypczak, Krystian Pyta, Piotr Ruszkowski, Maria Gdaniec, Franz Bartl

Eur J Med Chem· September 2020

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Specific Interactions between Rifamycin Antibiotics and Water Influencing Ability To Overcome Natural Cell Barriers and the Range of Antibacterial Potency.
Krystian Pyta, Anna Janas, Natalia Skrzypczak, Wojciech Schilf, Barbara Wicher

ACS Infect Dis· October 2019

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Synthesis, docking and antibacterial studies of more potent amine and hydrazone rifamycin congeners than rifampicin.
Krystian Pyta, Anna Janas, Monika Szukowska, Paulina Pecyna, Marcelina Jaworska

Eur J Med Chem· April 2019

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The mechanism of activation of amidobenzylidene ruthenium chelates - latent catalysts of olefin metathesis.
Szymon Rogalski, Patrycja Żak, Natalia Tadeuszyk, Krystian Pyta, Piotr Przybylski

Dalton Trans· January 2017

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16-Membered Macrolide Lactone Derivatives Bearing a Triazole-Functionalized Arm at the Aglycone C13 Position as Antibacterial and Anticancer Agents.
Joanna Domagalska, Anna Janas, Krystian Pyta, Paulina Pecyna, Piotr Ruszkowski

ChemMedChem· September 2016

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Synthesis, structure and antimicrobial evaluation of a new gossypol triazole conjugates functionalized with aliphatic chains and benzyloxy groups.
Krystian Pyta, Marietta Blecha, Anna Janas, Katarzyna Klich, Paulina Pecyna

Bioorg Med Chem Lett· September 2016

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Synthesis, Antibacterial, and Anticancer Evaluation of Novel Spiramycin-Like Conjugates Containing C(5) Triazole Arm.
Katarzyna Klich, Krystian Pyta, Marcelina M Kubicka, Piotr Ruszkowski, Lech Celewicz

J Med Chem· September 2016

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Structure-activity relationship studies of new rifamycins containing l-amino acid esters as inhibitors of bacterial RNA polymerases.
Dominika Czerwonka, Joanna Domagalska, Krystian Pyta, Marcelina M Kubicka, Paulina Pecyna

Eur J Med Chem· June 2016

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The effect of complexation of 3-formylrifamycin SV macrocyclic ether derivatives with metal cations and small nitrogen-containing organic molecules on antibacterial activity against S. aureus and S. epidermidis.
Piotr Przybylski, Krystian Pyta, Dominika Czerwonka, Marcelina M Kubicka, Marzena Gajecka

Bioorg Med Chem Lett· September 2015

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Regio- and Stereoselective Functionalization of 16-Membered Lactone Aglycone of Spiramycin via Cascade Strategy.
Katarzyna Klich, Krystian Pyta, Piotr Przybylski

J Org Chem· July 2015

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Regioselective long-range proton transfer in new rifamycin antibiotics: a process in which crown ethers act as stronger Brønsted bases than amines.
Krystian Pyta, Piotr Przybylski, Franz Bartl

Chemphyschem· April 2015

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Structure and evaluation of antibacterial and antitubercular properties of new basic and heterocyclic 3-formylrifamycin SV derivatives obtained via 'click chemistry' approach.
Krystian Pyta, Katarzyna Klich, Joanna Domagalska, Piotr Przybylski

Eur J Med Chem· September 2014

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13C and 15N CP/MAS, 1H-15N SCT CP/MAS and FTIR spectroscopy as tools for qualitative detection of the presence of zwitterionic and non-ionic forms of ansa-macrolide 3-formylrifamycin SV and its derivatives in solid state.
Piotr Przybylski, Krystian Pyta, Katarzyna Klich, Wojciech Schilf, Bohdan Kamieński

Magn Reson Chem· August 2014

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A new model of binding of rifampicin and its amino analogues as zwitterions to bacterial RNA polymerase.
Krystian Pyta, Piotr Przybylski, Katarzyna Klich, Joanna Stefańska

Org Biomol Chem· October 2012

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Redetermination of rifampicin pentahydrate revealing a zwitterionic form of the antibiotic.
Barbara Wicher, Krystian Pyta, Piotr Przybylski, Ewa Tykarska, Maria Gdaniec

Acta Crystallogr C· May 2012

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Intramolecular proton transfer impact on antibacterial properties of ansamycin antibiotic rifampicin and its new amino analogues.
Krystian Pyta, Piotr Przybylski, Barbara Wicher, Maria Gdaniec, Joanna Stefańska

Org Biomol Chem· March 2012

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MALDI-TOF tandem mass spectrometric analysis of novel aza-analogues of semi-synthetic ansamycin antibiotic--rifampicin.
Krystian Pyta, Piotr Przybylski

J Mass Spectrom· August 2011

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The influence of protonation on molecular structure and physico-chemical properties of gossypol Schiff bases.
Piotr Przybylski, Krystian Pyta, Justyna Czupryniak, Barbara Wicher, Maria Gdaniec

Org Biomol Chem· December 2010

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Structure elucidation, complete NMR assignment and PM5 theoretical studies of new hydroxy-aminoalkyl-alpha,beta-unsaturated derivatives of the macrolide antibiotic josamycin.
Piotr Przybylski, Krystian Pyta, Joanna Stefańska, Bogumil Brzezinski, Franz Bartl

Magn Reson Chem· April 2010

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Synthesis, crystal structures and antibacterial activity studies of aza-derivatives of phytoalexin from cotton plant--gossypol.
Piotr Przybylski, Krystian Pyta, Joanna Stefańska, Małgorzata Ratajczak-Sitarz, Andrzej Katrusiak

Eur J Med Chem· November 2009

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