Publications by authors named "Kuan-Ho Lin"

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MiR-493-3p suppresses the DPY-30 histone methyltransferase complex regulatory subunit to attenuate gefitinib resistance in lung cancer.
Valens Munyembaraga, Thomas Gabriel Mhone, Yung-Luen Yu, Ming-Cheng Chen, Chia-Hua Kuo, Kuan-Ho Lin

Transl Oncol· January 2026

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The role of Mir-365-5p in regulating NF2-Mediated apoptosis and ROS production in hypoxic cardiomyoblasts.
Chih-Hsueh Lin, Wei-Yun Wang, Bruce Chi-Kang Tsai, Wei-Wen Kuo, Chia-Hua Kuo, Kuan-Ho Lin, Shinn-Zong Lin

Mol Biol Rep· November 2025

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Therapeutic potential of cultivated with seeds for alleviating western diet-induced type 2 diabetes and diabetic nephropathy.
Shinn-Zong Lin, Wei-Wen Kuo, Bruce Chi-Kang Tsai, Catherine Reena Paul, Chia-Hua Kuo, Kuan-Ho Lin

Front Pharmacol· May 2025

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Trans-anethole enhances mesenchymal stem cell derived exosomes function to inhibit HO-induced rheumatoid arthritis-like inflammation in HIG-82 synovial cells.
Tai-Lung Huang, Yu-Chun Chang, Wei-Wen Kuo, Shih-Wen Kao, Chia-Hua Kuo, Kuan-Ho Lin

Mol Biol Rep· April 2025

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Jing-Si Herbal Tea Suppresses HO -Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG-82 Synoviocytes.
Shih-Wen Kao, Yu-Chun Chang, Feng-Huei Lin, Tai-Lung Huang, Tung-Sheng Chen, Shinn-Zong Lin, Kuan-Ho Lin

Environ Toxicol· December 2024

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Enhanced IGF-IIRα Expression Exacerbates Lipopolysaccharide-Induced Cardiac Inflammation, Hypertrophy, and Apoptosis Through Calcineurin Activation.
Khwanchit Boonha, Wei-Wen Kuo, Bruce Chi-Kang Tsai, Dennis Jine-Yuan Hsieh, Kuan-Ho Lin

Environ Toxicol· November 2024

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Platycodi radix aqueous extract salvages doxorubicin-induced senescence by mitochondrial reactive oxygen species reduction in umbilical cord matrix stem cells.
Pei-Ying Lee, Maria Angelina Sitorus, Chia-Hua Kuo, Bruce Chi-Kang Tsai, Wei-Wen Kuo, Kuan-Ho Lin, Yueh-Min Lin

Environ Toxicol· July 2024

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Calycosin Enhances Heat Shock Related-Proteins in H9c2 Cells to Modulate Survival and Apoptosis against Heat Shock.
Pei-Fang Lai, Ramasamy Mahendran, Bruce Chi-Kang Tsai, Cheng-You Lu, Chia-Hua Kuo, Kuan-Ho Lin, Yu-Ling Wu

Am J Chin Med· July 2024

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Renal protective effects of Alpinate Oxyphyllae Fructus and mesenchymal stem cells co-treatment against D- galactose induced renal deterioration.
Tsung-Jung Ho, Tamilselvi Shanmugam, Po-Hsiang Liao, Marthandam Asokan Shibu, William Shao-Tsu Chen, Kuan-Ho Lin

Int J Med Sci· June 2024

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Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210.
Kuan-Ho Lin, Shang-Chuan Ng, Shang-Yeh Lu, Yueh-Min Lin, Shu-Hui Lin

J Nutr Biochem· March 2024

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Anethole mitigates H O -induced inflammation in HIG-82 synoviocytes by suppressing the aquaporin 1 expression and activating the protein kinase A pathway.
Tai-Lung Huang, Yu-Chun Chang, Bruce Chi-Kang Tsai, Tung-Sheng Chen, Shih-Wen Kao, Shinn-Zong Lin, Kuan-Ho Lin

Environ Toxicol· February 2024

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Fisetin attenuates doxorubicin-induced cardiotoxicity by inhibiting the insulin-like growth factor II receptor apoptotic pathway through estrogen receptor-α/-β activation.
Kuan-Ho Lin, Samiraj Ramesh, Sakshi Agarwal, Wei-Wen Kuo, Chia-Hua Kuo, Yueh-Min Lin

Phytother Res· September 2023

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Cardiac-specific overexpression of insulin-like growth factor II receptor-α interferes with the regulation of calcium homeostasis in the heart under hyperglycemic conditions.
Shang-Yeh Lu, Bruce Chi-Kang Tsai, Dao Van Thao, Chin-Hu Lai, Michael Yu-Chih Chen, Kuan-Ho Lin

Mol Biol Rep· May 2023

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Insulin-like growth factor II receptor alpha overexpression in heart aggravates hyperglycemia-induced cardiac inflammation and myocardial necrosis.
Chin-Hu Lai, Dao Van Thao, Bruce Chi-Kang Tsai, Dennis Jine-Yuan Hsieh, Michael Yu-Chih Chen, Kuan-Ho Lin

Environ Toxicol· March 2023

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Carboxyl terminus of HSP70-interacting protein attenuates advanced glycation end products-induced cardiac injuries by promoting NFκB proteasomal degradation.
Kuan-Ho Lin, Ayaz Ali, Chia-Hua Kuo, Pei-Chen Yang, Velmurugan B Kumar

J Cell Physiol· March 2022

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MicroRNA-210 repression facilitates advanced glycation end-product (AGE)-induced cardiac mitochondrial dysfunction and apoptosis via JNK activation.
Kuan-Ho Lin, Shang-Chuan Ng, Catherine R Paul, Hong-Chen Chen, Ren-You Zeng

J Cell Biochem· December 2021

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Diallyl Trisulfide Suppresses High-Glucose-Induced Cardiomyocyte Apoptosis by Targeting Reactive Oxygen Species-Mediated Hypoxia-Inducible Factor-1α/Insulin-like Growth Factor Binding Protein 3 Activation.
Kuan-Ho Lin, Yu-Min Wei, Chung-Hung Liu, Jian-Sheng Liu, I-Chieh Huang

J Agric Food Chem· October 2021

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miR-145-5p targets paxillin to attenuate angiotensin II-induced pathological cardiac hypertrophy via downregulation of Rac 1, pJNK, p-c-Jun, NFATc3, ANP and by Sirt-1 upregulation.
Kuan-Ho Lin, V Bharath Kumar, Tamilselvi Shanmugam, Marthandam Asokan Shibu, Ray-Jade Chen

Mol Cell Biochem· September 2021

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Small Molecule Compound Nerolidol attenuates Hypertension induced hypertrophy in spontaneously hypertensive rats through modulation of Mel-18-IGF-IIR signalling.
Yueh-Min Lin, Khan Farheen Badrealam, Chia-Hua Kuo, Jayasimharayalu Daddam, Marthandam Asokan Shibu, Kuan-Ho Lin

Phytomedicine· April 2021

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Oral administration of green tea Epigallocatechin-3-gallate reduces oxidative stress and enhances restoration of cardiac function in diabetic rats receiving autologous transplantation of adipose-derived stem cells.
Tung-Sheng Chen, Show-Yih Liou, Hsin-Hung Lin, Meng-Yu Hung, Chien-Chung Lin, Yueh-Min Lin, Kuan-Ho Lin

Arch Physiol Biochem· February 2021

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Andrographolide mitigates cardiac apoptosis to provide cardio-protection in high-fat-diet-induced obese mice.
Kuan-Ho Lin, Shibu Marthandam Asokan, Wei-Wen Kuo, You-Liang Hsieh, Chong-Kuei Lii, Yi-Lin Lin, Shulin Wang

Environ Toxicol· June 2020

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Protective effects of luteolin against oxidative stress and mitochondrial dysfunction in endothelial cells.
Hsiu-I Chen, Wei-Syun Hu, Meng-Yu Hung, Hsiu-Chung Ou, Su-Hua Huang, Kuan-Ho Lin

Nutr Metab Cardiovasc Dis· June 2020

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Oridonin, A natural diterpenoid, protected NGF-differentiated PC12 cells against MPP- and kainic acid-induced injury.
Kuan-Ho Lin, Chien-Yu Li, Yuan-Man Hsu, Chang-Hai Tsai, Fuu-Jen Tsai

Food Chem Toxicol· November 2019

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17β-Estradiol and/or estrogen receptor alpha signaling blocks protein phosphatase 1 mediated ISO induced cardiac hypertrophy.
Hsin-Yuan Fang, Meng-Yu Hung, Yueh-Min Lin, Sudhir Pandey, Chia-Chien Chang, Kuan-Ho Lin

PLoS One· August 2018

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GABA tea attenuates cardiac apoptosis in spontaneously hypertensive rats (SHR) by enhancing PI3K/Akt-mediated survival pathway and suppressing Bax/Bak dependent apoptotic pathway.
Bih-Cheng Chen, Meng-Yu Hung, Hsueh-Fang Wang, Li-Jen Yeh, Sudhir Pandey, Ruey-Lin Chang, Kuan-Ho Lin

Environ Toxicol· July 2018

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