Publications by authors named "Kumar D Ashtekar"

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The role of kinase domain dimerization in EGFR activation.
Zaritza O Petrova, Long Han, Yuko Tsutsui, Joshua B Sheetz, Kumar D Ashtekar

Structure· December 2025

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Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes.
Krishna C Mudumbi, Eric A Burns, David J Schodt, Zaritza O Petrova, Anatoly Kiyatkin, Kumar D Ashtekar

Cell Rep· January 2024

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A destabilizing Y891D mutation in activated EGFR impairs sensitivity to kinase inhibition.
Daniel S Lenchner, Zaritza O Petrova, Lisa Hunihan, Kumar D Ashtekar, Zenta Walther

NPJ Precis Oncol· January 2024

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Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor.
Debanjan Bhattacharjee, Jaweria Bakar, Surbhi P Chitnis, Erin L Sausville, Kumar Dilip Ashtekar

Cell Chem Biol· October 2023

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Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes.
Krishna C Mudumbi, Eric A Burns, David J Schodt, Zaritza O Petrova, Anatoly Kiyatkin, Kumar D Ashtekar

bioRxiv· April 2023

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Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations.
Iris K van Alderwerelt van Rosenburgh, David M Lu, Michael J Grant, Steven E Stayrook, Manali Phadke, Kumar D Ashtekar

Nat Commun· November 2022

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A Mechanistically Inspired Halenium Ion Initiated Spiroketalization: Entry to Mono- and Dibromospiroketals.
Kumar Dilip Ashtekar, Hadi Gholami, Mehdi Moemeni, Ankush Chakraborty, Lindsey Kiiskila

Angew Chem Int Ed Engl· February 2022

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Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance Mutations.
Jacqueline H Starrett, Alexis A Guernet, Maria Emanuela Cuomo, Kamrine E Poels, Iris K van Alderwerelt van Rosenburgh, Kumar Dilip Ashtekar

Cancer Res· May 2020

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Mechanistic Insights into the Origin of Stereoselectivity in an Asymmetric Chlorolactonization Catalyzed by (DHQD)PHAL.
Roozbeh Yousefi, Aritra Sarkar, Kumar Dilip Ashtekar, Daniel C Whitehead, Tayeb Kakeshpour

J Am Chem Soc· April 2020

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Absolute and relative facial selectivities in organocatalytic asymmetric chlorocyclization reactions.
Nastaran Salehi Marzijarani, Roozbeh Yousefi, Arvind Jaganathan, Kumar Dilip Ashtekar, James E Jackson

Chem Sci· March 2018

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Mechanistically Inspired Route toward Hexahydro-2H-chromenes via Consecutive [4 + 2] Cycloadditions.
Kumar Dilip Ashtekar, Xinliang Ding, Edmond Toma, Wei Sheng, Hadi Gholami

Org Lett· August 2016

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Nucleophile-Assisted Alkene Activation: Olefins Alone Are Often Incompetent.
Kumar Dilip Ashtekar, Mathew Vetticatt, Roozbeh Yousefi, James E Jackson, Babak Borhan

J Am Chem Soc· July 2016

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A new tool to guide halofunctionalization reactions: the halenium affinity (HalA) scale.
Kumar Dilip Ashtekar, Nastaran Salehi Marzijarani, Arvind Jaganathan, Daniel Holmes, James E Jackson

J Am Chem Soc· September 2014

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Point-to-axial chirality transfer--a new probe for "sensing" the absolute configurations of monoamines.
Mercy Anyika, Hadi Gholami, Kumar D Ashtekar, Robert Acho, Babak Borhan

J Am Chem Soc· January 2014

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Dissecting the stereocontrol elements of a catalytic asymmetric chlorolactonization: syn addition obviates bridging chloronium.
Roozbeh Yousefi, Kumar Dilip Ashtekar, Daniel C Whitehead, James E Jackson, Babak Borhan

J Am Chem Soc· October 2013

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Development of a formal catalytic asymmetric [4+2] addition of ethyl-2,3-butadienoate with acyclic enones.
Kumar Dilip Ashtekar, Richard J Staples, Babak Borhan

Org Lett· November 2011

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