Publications by authors named "Kunikazu Moribe"

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In situ SAXS and rheological correlation of microstructural evolution during the sol-gel transition of Poloxamer 407 modulated by Poloxamer 188.
Prakasit Panyamao, Kenjirou Higashi, Keisuke Ueda, Chalermpong Saenjum, Kunikazu Moribe

J Colloid Interface Sci· March 2026

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Role of carriers and pre-dissolved polymers in drug-rich nanodroplet formation during dissolution of amorphous drug formulations.
Rei Hakata, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe

J Pharm Sci· November 2025

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Nanomorphology tuning in doxorubicin-loaded liposomes cooling-induced doxorubicin-crystallization and membrane phase transition.
Koki Nishimura, Taiki Fujimoto, Taisei Tokumoto, Kenjirou Higashi, Ryo Hidaka, Kunikazu Moribe

Chem Commun (Camb)· July 2025

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Thermodynamic Perspectives on the Impact of a Second Drug on Amorphous Drug Solubility.
Shun Kaneko, Keisuke Ueda, Rei Hakata, Kenjirou Higashi, Masataka Ito, Kunikazu Moribe

Mol Pharm· July 2025

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Mechanistic insights into drug supersaturation during lipid digestion in self-emulsifying drug delivery systems: A cryo-TEM and NMR study.
Keisuke Ueda, Riku Uchiyama, Nao Kato, Kenjirou Higashi, Kunikazu Moribe

Int J Pharm· April 2025

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A Post-Encapsulation Method for the Preparation of mRNA-LNPs via the Nucleic Acid-Bridged Fusion of mRNA-Free LNPs.
Hiroki Tanaka, Yuka Sato, Tomoya Nakabayashi, Akari Tanaka, Kazuma Nishio, Kunikazu Moribe

Nano Lett· April 2025

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Impact of Microemulsion Oil Components on Liquid-Liquid Phase Separation of a Supersaturated Drug Revealed by Cryo-TEM and H NMR Analysis.
Risa Edera, Keisuke Ueda, Saeko Tomita, Kenjirou Higashi, Kunikazu Moribe

Mol Pharm· March 2025

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Impact of colloidal drug-rich droplet size and amorphous solubility on drug membrane permeability: A comprehensive analysis.
Keisuke Ueda, Shiryu Takemoto, Kenjirou Higashi, Kunikazu Moribe

J Pharm Sci· January 2025

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NMR-based analysis of impact of siRNA mixing conditions on internal structure of siRNA-loaded LNP.
Keisuke Ueda, Yui Sakagawa, Tomoki Saito, Fumie Sakuma, Hiroki Tanaka, Kunikazu Moribe

J Control Release· September 2024

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Effect of Acetaminophen on Poloxamer 407 Micelles and Hydrogels: The Relationship between Structural and Physical Properties.
Fumie Sakuma, Kenjirou Higashi, Keisuke Ueda, Takeshi Morita, Daisuke Iohara, Kunikazu Moribe

Langmuir· July 2024

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Quantitative Investigation of Intestinal Drug Absorption Enhancement by Drug-Rich Nanodroplets Generated via Liquid-Liquid Phase Separation.
Etsushi Yoshikawa, Keisuke Ueda, Rei Hakata, Kenjirou Higashi, Kunikazu Moribe

Mol Pharm· April 2024

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Mechanistic Analysis of Temperature-Dependent Curcumin Release from Poly(lactic-co-glycolic acid)/Poly(lactic acid) Polymer Nanoparticles.
Yushi Sunazuka, Keisuke Ueda, Kenjirou Higashi, Koichi Wada, Kunikazu Moribe

Mol Pharm· March 2024

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Controlled Sublimation Rate of Guest Drug from Polymorphic Forms of a Cyclodextrin-Based Polypseudorotaxane Complex and Its Correlation with Molecular Dynamics as Probed by Solid-State NMR.
Sudeshna Kundu, Kenjirou Higashi, Makoto Takamizawa, Keisuke Ueda, Waree Limwikrant, Kunikazu Moribe

Mol Pharm· March 2024

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The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles.
Jessica Anindita, Hiroki Tanaka, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kunikazu Moribe

Pharmaceutics· January 2024

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Unveiling the flavone-solubilizing effects of α-glucosyl rutin and hesperidin: probing structural differences through NMR and SAXS analyses.
Kazunori Kadota, Tero Kämäräinen, Fumie Sakuma, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe

Food Funct· November 2023

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New liposome-radionuclide-chelate combination for tumor targeting and rapid healthy tissue clearance.
Izumi O Umeda, Yusuke Koike, Mayumi Ogata, Emi Kaneko, Shusei Hamamichi, Kunikazu Moribe

J Control Release· September 2023

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Molecular-Level Structural Analysis of siRNA-Loaded Lipid Nanoparticles by H NMR Relaxometry: Impact of Lipid Composition on Their Structural Properties.
Keisuke Ueda, Yui Sakagawa, Tomoki Saito, Taiki Fujimoto, Misaki Nakamura, Kunikazu Moribe

Mol Pharm· September 2023

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Designing a Novel Coamorphous Salt Formulation of Telmisartan with Amlodipine to Enhance Permeability and Oral Absorption.
Yuta Hatanaka, Hiromasa Uchiyama, Shun Kaneko, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe

Mol Pharm· August 2023

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Preparation of a ternary amorphous solid dispersion using hot-melt extrusion for obtaining a stable colloidal dispersion of amorphous probucol nanoparticles.
Naho Hanada, Kenjirou Higashi, Zhijing Zhao, Keisuke Ueda, Kunikazu Moribe

Int J Pharm· June 2023

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Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 2: Effects of Solubilizer.
Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe

Mol Pharm· April 2023

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Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 1: Effects of Polymer and Drug Chiralities.
Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe

Mol Pharm· April 2023

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Supersaturation maintenance of carvedilol and chlorthalidone by cyclodextrin derivatives: Pronounced crystallization inhibition ability of methylated cyclodextrin.
Mengyao Liu, Kenjirou Higashi, Keisuke Ueda, Kunikazu Moribe

Int J Pharm· April 2023

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Understanding the rod-to-tube transformation of self-assembled ascorbyl dipalmitate lipid nanoparticles stabilized with PEGylated lipids.
Ziqiao Chen, Kenjirou Higashi, Yuki Shigehisa, Keisuke Ueda, Keiji Yamamoto, Kunikazu Moribe

Nanoscale· February 2023

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Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA.
Hiroki Tanaka, Shinya Hagiwara, Daiki Shirane, Takuma Yamakawa, Yuka Sato, Kunikazu Moribe

ACS Nano· February 2023

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Drug-Loaded Nanocarriers Composed of Cholesteryl Oleate Crystal Cores and Multiple-Nanosheet Shells of γ-Cyclodextrin Inclusion Complex Crystals.
Arisa Ishimoto, Hiroshi Sasako, Masaki Omori, Kenjirou Higashi, Keisuke Ueda, Kunikazu Moribe

Langmuir· August 2022

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