Publications by authors named "Kusma Pyakurel"

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Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex.
Mohamed A Ghonim, Jihang Ju, Kusma Pyakurel, Salome V Ibba, Mai M Abouzeid

J Inflamm (Lond)· April 2024

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Acute effect of inhaled iloprost on exercise dynamic hyperinflation in COPD patients: A randomized crossover study.
Matthew R Lammi, Mohamed A Ghonim, Jessica Johnson, Johnny D'Aquin, John B Zamjahn, Kusma Pyakurel

Respir Med· December 2021

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Microparticles in systemic sclerosis: Potential pro-inflammatory mediators and pulmonary hypertension biomarkers.
Matthew R Lammi, Lesley Ann Saketkoo, Samuel C Okpechi, Mohamed A Ghonim, Dorota Wyczechowska, Kusma Pyakurel

Respirology· July 2019

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Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway.
Mohamed A Ghonim, Jeffrey Wang, Salome V Ibba, Hanh H Luu, Kusma Pyakurel

J Transl Med· September 2018

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Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity.
Salome' V Ibba, Mohamed A Ghonim, Kusma Pyakurel, Matthew R Lammi, Anil Mishra

Mediators Inflamm· May 2017

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Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD.
Matthew R Lammi, Mohamed A Ghonim, Kusma Pyakurel, Amarjit S Naura, Salome V Ibba

Am J Physiol Lung Cell Mol Physiol· April 2016

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PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice.
Mohamed A Ghonim, Kusma Pyakurel, Salome V Ibba, Jeffrey Wang, Paulo Rodriguez

Clin Sci (Lond)· December 2015

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PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.
Mohamed A Ghonim, Kusma Pyakurel, Salome V Ibba, Amir A Al-Khami, Jeffrey Wang

J Transl Med· July 2015

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DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency.
Mohamed A Ghonim, Kusma Pyakurel, Jihang Ju, Paulo C Rodriguez, Matthew R Lammi

J Allergy Clin Immunol· February 2015

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Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor κB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase.
Amarjit S Naura, Hogyoung Kim, Jihang Ju, Paulo C Rodriguez, Joaquin Jordan, Kusma Pyakurel

J Biol Chem· January 2013

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