Publications by authors named "Kyle A Mack"

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Bisphosphine ligand conformer selection to enhance descriptor database representation: improving statistical modelling outcomes.
Jamie A Cadge, Sierra D Hart, Richard C Walroth, Kyle A Mack, Matthew S Sigman

Chem Sci· November 2025

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Utopia Point Bayesian Optimization Finds Condition-Dependent Selectivity for -Methyl Pyrazole Condensation.
Derek M Dalton, Richard C Walroth, Caroline Rouget-Virbel, Kyle A Mack, F Dean Toste

J Am Chem Soc· June 2024

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Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine Ligands.
Jordan J Dotson, Lucy van Dijk, Jacob C Timmerman, Samantha Grosslight, Richard C Walroth, Kyle A Mack

J Am Chem Soc· January 2023

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Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.
Jie Xu, Samantha Grosslight, Kyle A Mack, Sierra C Nguyen, Kyle Clagg

J Am Chem Soc· November 2022

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Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Acyclic Olefins.
Raphael Bigler, Kyle A Mack, Jeff Shen, Paolo Tosatti, Chong Han

Angew Chem Int Ed Engl· February 2020

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Phosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2-]pyrimidine Isomers.
Nicholas A White, Kyle Clagg, Lauren E Sirois, Kyle A Mack, Mohammad A Al-Sayah

Org Lett· December 2019

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Case for Lithium Tetramethylpiperidide-Mediated Ortholithiations: Reactivity and Mechanisms.
Kyle A Mack, David B Collum

J Am Chem Soc· April 2018

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Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities.
Kyle A Mack, Andrew McClory, Haiming Zhang, Francis Gosselin, David B Collum

J Am Chem Soc· September 2017

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Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-Carbon Olefins via Enol Tosylation and Suzuki-Miyaura Coupling.
Beryl X Li, Diane N Le, Kyle A Mack, Andrew McClory, Ngiap-Kie Lim

J Am Chem Soc· August 2017

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Lithium Enolates in the Enantioselective Construction of Tetrasubstituted Carbon Centers with Chiral Lithium Amides as Noncovalent Stereodirecting Auxiliaries.
Kai Yu, Ping Lu, Jeffrey J Jackson, Thuy-Ai D Nguyen, Joseph Alvarado, Kyle A Mack

J Am Chem Soc· January 2017

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Mixed Aggregates of the Dilithiated Koga Tetraamine: NMR Spectroscopic and Computational Studies.
Yun Ma, Kyle A Mack, Jun Liang, Ivan Keresztes, David B Collum

Angew Chem Int Ed Engl· August 2016

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