Publications by authors named "Kyle Biggar"

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Thermal profiling of novel and known miRNAs during cold acclimation in Aedes aegypti.
Ella H M De Nicola, Kyle K Biggar, Heath A MacMillan

Comp Biochem Physiol Part D Genomics Proteomics· December 2025

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Design of a selective peptide inhibitor targeting KDM5C demethylase activity.
Valentina Lukinović, Hemanta Adhikary, Matthew Hoekstra, Ali Shukri, Francois Charih, Kyle K Biggar

Structure· November 2025

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Machine learning-driven prediction of substrates for enzymes introducing or removing protein post-translational modifications.
Nashira H Ridgeway, Anand Chopra, Valentina Lukinović, Michal Feldman, François Charih, Kyle K Biggar

Commun Chem· November 2025

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Mass Spectrometry for Lysine Methylation: Principles, Progress, and Prospects.
Mackenzie G Cumming, Kyle K Biggar

Biomedicines· November 2025

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Exploration into the MLL4/WRAD Enzyme-Substrate Network: Systematic In Vitro Identification of CFP1 as a Potential Non-Histone Substrate of the MLL4 Lysine Methyltransferase.
Mullen Boulter, Ryan Collins, Kyle K Biggar

Epigenomes· October 2025

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Leveraging learned representations and multitask learning for lysine methylation site discovery.
François Charih, Mullen Boulter, Kyle K Biggar, James R Green

bioRxiv· September 2025

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Sequence-Based Protein-Protein Interaction Prediction and Its Applications in Drug Discovery.
François Charih, James R Green, Kyle K Biggar

Cells· September 2025

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Uncovering Enzyme-Specific Post-Translational Modifications: An Overview of Current Methods.
Nashira H Ridgeway, Kyle K Biggar

Proteomes· August 2025

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Future Perspective: Harnessing the Power of Artificial Intelligence in the Generation of New Peptide Drugs.
Nour Nissan, Mitchell C Allen, David Sabatino, Kyle K Biggar

Biomolecules· October 2024

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Biological Relevance of Dual Lysine and N-Terminal Methyltransferase METTL13.
Mullen Boulter, Kyle K Biggar

Biomolecules· September 2024

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Systematic optimization of antimicrobial peptides against .
Ali Shukri, Amanda C Carroll, Ryan Collins, Francois Charih, Alex Wong, Kyle K Biggar

JAC Antimicrob Resist· August 2024

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In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation.
Viktoria Xing, Kyle Biggar, Stephen S G Ferguson, Shawn Hayley

Mol Brain· February 2024

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Unraveling the battle for lysine: A review of the competition among post-translational modifications.
Ali H Shukri, Valentina Lukinović, François Charih, Kyle K Biggar

Biochim Biophys Acta Gene Regul Mech· December 2023

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Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability.
Fredrick J Rosario, Anand Chopra, Kyle Biggar, Theresa L Powell, Madhulika B Gupta

Int J Mol Sci· April 2023

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PeSA 2.0: A software tool for peptide specificity analysis implementing positive and negative motifs and motif-based peptide scoring.
Emine Topcu, Nashira H Ridgeway, Kyle K Biggar

Comput Biol Chem· December 2022

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Characterization of KDM5 lysine demethylase family substrate preference and identification of novel substrates.
Matthew Hoekstra, Nashira H Ridgeway, Kyle K Biggar

J Biochem· December 2022

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A peptide array pipeline for the development of Spike-ACE2 interaction inhibitors.
Anand Chopra, Ali H Shukri, Hemanta Adhikary, Valentina Lukinović, Matthew Hoekstra, Kyle K Biggar

Peptides· December 2022

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Assessing the in vitro Binding Affinity of Protein-RNA Interactions Using an RNA Pull-down Technique.
Anand Chopra, Feras Balbous, Kyle K Biggar

Bio Protoc· December 2022

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TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma.
Lee Admoni-Elisha, Tzofit Elbaz, Anand Chopra, Guy Shapira, Mark T Bedford, Kyle Biggar

Nucleic Acids Res· July 2022

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Increased Colocalization and Interaction Between Decidual Protein Kinase A and Insulin-like Growth Factor-Binding Protein-1 in Intrauterine Growth Restriction.
Madhulika B Gupta, Kyle K Biggar, Cun Li, Peter W Nathanielsz, Thomas Jansson

J Histochem Cytochem· July 2022

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Evaluation of Jumonji C lysine demethylase substrate preference to guide identification of substrates.
Matthew Hoekstra, Anand Chopra, William G Willmore, Kyle K Biggar

STAR Protoc· June 2022

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Assessing sequence-based protein-protein interaction predictors for use in therapeutic peptide engineering.
François Charih, Kyle K Biggar, James R Green

Sci Rep· June 2022

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Insights into a Cancer-Target Demethylase: Substrate Prediction through Systematic Specificity Analysis for KDM3A.
Anand Chopra, William G Willmore, Kyle K Biggar

Biomolecules· April 2022

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Identification of in vitro JMJD lysine demethylase candidate substrates via systematic determination of substrate preference.
Matthew Hoekstra, Kyle K Biggar

Anal Biochem· November 2021

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Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells.
Pinki Nandi, Chloe E Jang, Kyle Biggar, Chidambra D Halari, Thomas Jansson

Biomolecules· September 2021

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