Publications by authors named "Kyle D Konze"

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The Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin αvβ6 Inhibitor for Fibrosis.
Bryce A Harrison, James E Dowling, Matthew G Bursavich, Dawn M Troast, Katherine M Chong, Kyle D Konze

J Med Chem· November 2024

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Combining Cloud-Based Free-Energy Calculations, Synthetically Aware Enumerations, and Goal-Directed Generative Machine Learning for Rapid Large-Scale Chemical Exploration and Optimization.
Phani Ghanakota, Pieter H Bos, Kyle D Konze, Joshua Staker, Gabriel Marques

J Chem Inf Model· September 2020

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Reaction-Based Enumeration, Active Learning, and Free Energy Calculations To Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin-Dependent Kinase 2 Inhibitors.
Kyle D Konze, Pieter H Bos, Markus K Dahlgren, Karl Leswing, Ivan Tubert-Brohman

J Chem Inf Model· September 2019

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Multi-omic Dissection of Oncogenically Active Epiproteomes Identifies Drivers of Proliferative and Invasive Breast Tumors.
John A Wrobel, Ling Xie, Li Wang, Cui Liu, Naim Rashid, Kyle D Konze

iScience· July 2019

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Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.
Xiaobao Yang, Fengling Li, Kyle D Konze, Jamel Meslamani, Anqi Ma

J Med Chem· August 2016

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Targeting EZH2 and PRC2 dependence as novel anticancer therapy.
Bowen Xu, Kyle D Konze, Jian Jin, Gang Greg Wang

Exp Hematol· August 2015

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Selective inhibitors of protein methyltransferases.
H Ümit Kaniskan, Kyle D Konze, Jian Jin

J Med Chem· February 2015

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Polycomb genes, miRNA, and their deregulation in B-cell malignancies.
Gang Greg Wang, Kyle D Konze, Jianguo Tao

Blood· February 2015

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Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.
Bowen Xu, Doan M On, Anqi Ma, Trevor Parton, Kyle D Konze

Blood· January 2015

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An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.
Kyle D Konze, Anqi Ma, Fengling Li, Dalia Barsyte-Lovejoy, Trevor Parton

ACS Chem Biol· August 2014

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A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a.
Kyle D Konze, Samantha G Pattenden, Feng Liu, Dalia Barsyte-Lovejoy, Fengling Li

ChemMedChem· March 2014

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