Publications by authors named "Kyle Defrees"

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Structure-Based Ligand Design Targeting LpxA in Lipid A Biosynthesis.
Michael D Sacco, Kyle Defrees, Xiujun Zhang, William Lawless, Emeka Nwanochie

ACS Infect Dis· July 2022

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Mutation of the conserved Asp-Asp pair impairs the structure, function, and inhibition of CTX-M Class A β-lactamase.
M Trent Kemp, Derek A Nichols, Xiujun Zhang, Kyle Defrees, Insung Na

FEBS Lett· December 2021

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Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.
Nicholas J Torelli, Afroza Akhtar, Kyle DeFrees, Priyadarshini Jaishankar, Orville A Pemberton

ACS Infect Dis· June 2019

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An Empirical Study of Amide-Heteroarene π-Stacking Interactions Using Reversible Inhibitors of a Bacterial Serine Hydrolase.
Kyle DeFrees, M Trent Kemp, Xochina ElHilali-Pollard, Xiujun Zhang, Ahmed Mohamed

Org Chem Front· June 2019

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Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases.
Orville A Pemberton, Xiujun Zhang, Derek A Nichols, Kyle DeFrees, Priyadarshini Jaishankar

Antimicrob Agents Chemother· August 2018

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Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography.
Derek A Nichols, Jacqueline C Hargis, Ruslan Sanishvili, Priyadarshini Jaishankar, Kyle Defrees

J Am Chem Soc· July 2015

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Effect of pendant group on pDNA delivery by cationic-β-cyclodextrin:alkyl-PVA-PEG pendant polymer complexes.
Aditya Kulkarni, Vivek Badwaik, Kyle DeFrees, Ryan A Schuldt, Dinara S Gunasekera

Biomacromolecules· January 2014

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Microfluidic Assembly of Cationic-β-Cyclodextrin:Hyaluronic Acid-Adamantane Host:Guest pDNA Nanoparticles.
Aditya Kulkarni, Ross Verheul, Kyle Defrees, Christopher J Collins, Ryan A Schuldt

Biomater Sci· October 2013

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Cationic α-cyclodextrin:poly(ethylene glycol) polyrotaxanes for siRNA delivery.
Aditya Kulkarni, Kyle DeFrees, Ryan A Schuldt, Seok-Hee Hyun, Kyle J Wright

Mol Pharm· April 2013

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Multi-armed cationic cyclodextrin:poly(ethylene glycol) polyrotaxanes as efficient gene silencing vectors.
Aditya Kulkarni, Kyle DeFrees, Ryan A Schuldt, Alexander Vlahu, Ross VerHeul

Integr Biol (Camb)· January 2013

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Pendant polymer:amino-β-cyclodextrin:siRNA guest:host nanoparticles as efficient vectors for gene silencing.
Aditya Kulkarni, Kyle DeFrees, Seok-Hee Hyun, David H Thompson

J Am Chem Soc· May 2012

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