Publications by authors named "Kym Lowes"

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MK-7602: a potent multi-stage dual-targeting antimalarial.
Paola Favuzza, Josephine Palandri, Manuel de Lera Ruiz, Wendy Bailey, Christopher W Boyce, Kym N Lowes

EBioMedicine· December 2025

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Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity.
Xinyu Wu, Shane M Devine, Margareta Go, Julie V Nguyen, Bernadine G C Lu, Kym N Lowes

PLoS Pathog· September 2025

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A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.
Stefanie M Bader, Dale J Calleja, Shane M Devine, Nathan W Kuchel, Bernadine G C Lu, Kym N Lowes

Nat Commun· April 2025

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Differential regulation of BAX and BAK apoptotic activity revealed by small molecules.
Kaiming Li, Yu Q Yap, Donia M Moujalled, Fransisca Sumardy, Yelena Khakham, Kym Lowes

Sci Adv· March 2025

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Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape.
Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Kym N Lowes

Nat Commun· July 2024

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The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase.
Catia L Pierotti, Annette V Jacobsen, Christoph Grohmann, Ruby K Dempsey, Nima Etemadi, Kym N Lowes

Biochem J· May 2023

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Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.
Trent D Ashton, Madeline G Dans, Paola Favuzza, Anna Ngo, Adele M Lehane, Kym N Lowes

J Med Chem· March 2023

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Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Petar P S Calic, Natalie B Vinh, Chaille T Webb, Tess R Malcolm, Anna Ngo, Kym Lowes

Eur J Med Chem· February 2023

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RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting.
Julie Healer, Jennifer K Thompson, Karen L Mackwell, Cecille D Browne, Benjamin A Seager, Kym N Lowes

Front Cell Infect Microbiol· January 2023

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The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria.
Manuel de Lera Ruiz, Paola Favuzza, Zhuyan Guo, Lianyun Zhao, Bin Hu, Kym N Lowes

ACS Med Chem Lett· November 2022

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Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.
Anthony N Hodder, Janni Christensen, Stephen Scally, Tony Triglia, Anna Ngo, Kym Lowes

Structure· July 2022

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The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
Annette V Jacobsen, Catia L Pierotti, Kym N Lowes, Amanda E Au, Ying Zhang

Cell Death Dis· April 2022

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Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors.
Dale J Calleja, Nathan Kuchel, Bernadine G C Lu, Richard W Birkinshaw, Theresa Klemm, Kym N Lowes

Front Chem· April 2022

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Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity.
Trent D Ashton, Anna Ngo, Paola Favuzza, Hayley E Bullen, Maria R Gancheva, Kym N Lowes

Bioorg Chem· December 2021

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Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.
Brodie L Bailey, William Nguyen, Anna Ngo, Christopher D Goodman, Maria R Gancheva, Kym N Lowes

Bioorg Chem· October 2021

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Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
William Nguyen, Erinna F Lee, Marco Evangelista, Mihwa Lee, Tiffany J Harris, Kym N Lowes

ACS Infect Dis· May 2021

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Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion.
William Nguyen, Madeline G Dans, Anna Ngo, Maria R Gancheva, Ornella Romeo, Kym N Lowes

Eur J Med Chem· March 2021

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Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Kym N Lowes

EMBO J· September 2020

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A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
Mark F van Delft, Stephane Chappaz, Yelena Khakham, Chinh T Bui, Marlyse A Debrincat, Kym N Lowes

Nat Chem Biol· November 2019

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Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.
Emma J Petrie, Jarrod J Sandow, Wil I L Lehmann, Lung-Yu Liang, Diane Coursier, Kym N Lowes

Cell Rep· September 2019

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Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity.
Jing Wang, Dmitri Mouradov, Xiaojing Wang, Robert N Jorissen, Matthew C Chambers, Kym Lowes

Gastroenterology· October 2017

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Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.
Paul R Gilson, Cyrus Tan, Kate E Jarman, Kym N Lowes, Joan M Curtis

J Med Chem· February 2017

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Exploration of the P3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V.
Michelle Gazdik, Kate E Jarman, Matthew T O'Neill, Anthony N Hodder, Kym N Lowes

Bioorg Med Chem· May 2016

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Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
Anthony N Hodder, Brad E Sleebs, Peter E Czabotar, Michelle Gazdik, Yibin Xu, Kym Lowes

Nat Struct Mol Biol· August 2015

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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.
Joel D Leverson, Darren C Phillips, Michael J Mitten, Erwin R Boghaert, Dolores Diaz, Kym N Lowes

Sci Transl Med· March 2015

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