Publications by authors named "LJ Friedman"

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A mechanism of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence.
Daniel H Zhou, Jongcheol Jeon, Nida Farheen, Larry J Friedman, Jane Kondev

Mol Cell· November 2025

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An Orc6 tether mediates ORC binding-site switching during replication origin licensing.
David Driscoll, Larry J Friedman, Jeff Gelles, Stephen P Bell

Proc Natl Acad Sci U S A· October 2025

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An Orc6 tether mediates ORC binding site switching during replication origin licensing.
David Driscoll, Larry J Friedman, Jeff Gelles, Stephen P Bell

bioRxiv· May 2025

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Single-molecule analysis of transcription activation: dynamics of SAGA coactivator recruitment.
Jongcheol Jeon, Larry J Friedman, Daniel H Zhou, Hogyu David Seo, Oluwatobi A Adeleke

Nat Struct Mol Biol· April 2025

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Mechanism of client loading from BiP to Grp94 and its disruption by select inhibitors.
Tara P Azam, Jiaqi Han, Erin E Deans, Bin Huang, Reyal Hoxie, Larry J Friedman

Nat Commun· April 2025

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Mechanisms of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence.
Daniel H Zhou, Jongcheol Jeon, Nida Farheen, Larry J Friedman, Jane Kondev

bioRxiv· December 2024

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Single-molecule analysis of transcription activation: dynamics of SAGA co-activator recruitment.
Jongcheol Jeon, Larry J Friedman, Hogyu David Seo, Augustus Adeleke, Bria Graham

bioRxiv· August 2023

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Recycling of bacterial RNA polymerase by the Swi2/Snf2 ATPase RapA.
Koe Inlow, Debora Tenenbaum, Larry J Friedman, Jane Kondev, Jeff Gelles

Proc Natl Acad Sci U S A· July 2023

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Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing.
Audra L Amasino, Shalini Gupta, Larry J Friedman, Jeff Gelles, Stephen P Bell

Proc Natl Acad Sci U S A· July 2023

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RNA polymerase sliding on DNA can couple the transcription of nearby bacterial operons.
Debora Tenenbaum, Koe Inlow, Larry J Friedman, Anthony Cai, Jeff Gelles

Proc Natl Acad Sci U S A· July 2023

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Changing protein-DNA interactions promote ORC binding-site exchange during replication origin licensing.
Annie Zhang, Larry J Friedman, Jeff Gelles, Stephen P Bell

Proc Natl Acad Sci U S A· July 2023

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Changing protein-DNA interactions promote ORC binding site exchange during replication origin licensing.
Annie Zhang, Larry J Friedman, Jeff Gelles, Stephen P Bell

bioRxiv· June 2023

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Recycling of Bacterial RNA Polymerase by the Swi2/Snf2 ATPase RapA.
Koe Inlow, Debora Tenenbaum, Larry J Friedman, Jane Kondev, Jeff Gelles

bioRxiv· March 2023

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Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing.
Audra Amasino, Shalini Gupta, Larry J Friedman, Jeff Gelles, Stephen P Bell

bioRxiv· January 2023

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Bayesian machine learning analysis of single-molecule fluorescence colocalization images.
Yerdos A Ordabayev, Larry J Friedman, Jeff Gelles, Douglas L Theobald

Elife· March 2022

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The endoplasmic reticulum chaperone BiP is a closure-accelerating cochaperone of Grp94.
Bin Huang, Ming Sun, Reyal Hoxie, Judy L M Kotler, Larry J Friedman

Proc Natl Acad Sci U S A· February 2022

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A helicase-tethered ORC flip enables bidirectional helicase loading.
Shalini Gupta, Larry J Friedman, Jeff Gelles, Stephen P Bell

Elife· December 2021

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Single-molecule studies reveal branched pathways for activator-dependent assembly of RNA polymerase II pre-initiation complexes.
Inwha Baek, Larry J Friedman, Jeff Gelles, Stephen Buratowski

Mol Cell· September 2021

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DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7.
Lorraine De Jesús-Kim, Larry J Friedman, Marko Lõoke, Christian K Ramsoomair, Jeff Gelles

Elife· February 2021

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Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription.
Grace A Rosen, Inwha Baek, Larry J Friedman, Yoo Jin Joo, Stephen Buratowski

Proc Natl Acad Sci U S A· December 2020

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Conformational Cycling within the Closed State of Grp94, an Hsp90-Family Chaperone.
Bin Huang, Larry J Friedman, Ming Sun, Jeff Gelles, Timothy O Street

J Mol Biol· August 2019

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A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding.
Kanokwan Champasa, Caitlin Blank, Larry J Friedman, Jeff Gelles, Stephen P Bell

Elife· August 2019

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Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription.
Sarah K Stumper, Harini Ravi, Larry J Friedman, Rachel Anne Mooney, Ivan R Corrêa

Elife· February 2019

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Synergistic assembly of human pre-spliceosomes across introns and exons.
Joerg E Braun, Larry J Friedman, Jeff Gelles, Melissa J Moore

Elife· June 2018

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Mechanism and timing of Mcm2-7 ring closure during DNA replication origin licensing.
Simina Ticau, Larry J Friedman, Kanokwan Champasa, Ivan R Corrêa, Jeff Gelles

Nat Struct Mol Biol· March 2017

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