Publications by authors named "Timothy O Street"

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Mechanism of client loading from BiP to Grp94 and its disruption by select inhibitors.
Tara P Azam, Jiaqi Han, Erin E Deans, Bin Huang, Reyal Hoxie, Timothy O Street

Nat Commun· April 2025

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Mechanisms of Protein Quality Control in the Endoplasmic Reticulum by a Coordinated Hsp40-Hsp70-Hsp90 System.
Judy L M Kotler, Timothy O Street

Annu Rev Biophys· May 2023

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Electrostatics Drive the Molecular Chaperone BiP to Preferentially Bind Oligomerized States of a Client Protein.
Erin E Deans, Judy L M Kotler, Wei-Shao Wei, Timothy O Street

J Mol Biol· July 2022

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The endoplasmic reticulum chaperone BiP is a closure-accelerating cochaperone of Grp94.
Bin Huang, Ming Sun, Reyal Hoxie, Judy L M Kotler, Larry J Friedman, Timothy O Street

Proc Natl Acad Sci U S A· February 2022

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The ER Chaperones BiP and Grp94 Regulate the Formation of Insulin-Like Growth Factor 2 (IGF2) Oligomers.
Yi Jin, Judy L M Kotler, Shiyu Wang, Bin Huang, Jackson C Halpin, Timothy O Street

J Mol Biol· June 2021

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Hsp90 chaperones have an energetic hot-spot for binding inhibitors.
Reyal S Hoxie, Timothy O Street

Protein Sci· October 2020

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Multimapping confounds ribosome profiling analysis: A case-study of the Hsp90 molecular chaperone.
Jackson C Halpin, Radhika Jangi, Timothy O Street

Proteins· January 2020

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Conformational Cycling within the Closed State of Grp94, an Hsp90-Family Chaperone.
Bin Huang, Larry J Friedman, Ming Sun, Jeff Gelles, Timothy O Street

J Mol Biol· August 2019

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The endoplasmic reticulum (ER) chaperones BiP and Grp94 selectively associate when BiP is in the ADP conformation.
Ming Sun, Judy L M Kotler, Shanshan Liu, Timothy O Street

J Biol Chem· April 2019

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Hsp90 Sensitivity to ADP Reveals Hidden Regulation Mechanisms.
Jackson C Halpin, Timothy O Street

J Mol Biol· September 2017

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Molecular mechanism of bacterial Hsp90 pH-dependent ATPase activity.
Yi Jin, Reyal S Hoxie, Timothy O Street

Protein Sci· June 2017

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5'-N-ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor.
Shanshan Liu, Timothy O Street

Protein Sci· December 2016

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Crowding Activates Heat Shock Protein 90.
Jackson C Halpin, Bin Huang, Ming Sun, Timothy O Street

J Biol Chem· March 2016

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Two-sided block of a dual-topology F- channel.
Daniel L Turman, Jacob T Nathanson, Randy B Stockbridge, Timothy O Street, Christopher Miller

Proc Natl Acad Sci U S A· May 2015

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Elucidating the mechanism of substrate recognition by the bacterial Hsp90 molecular chaperone.
Timothy O Street, Xiaohui Zeng, Riccardo Pellarin, Massimiliano Bonomi, Andrej Sali

J Mol Biol· June 2014

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Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast.
Olivier Genest, Michael Reidy, Timothy O Street, Joel R Hoskins, Jodi L Camberg

Mol Cell· February 2013

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Cross-monomer substrate contacts reposition the Hsp90 N-terminal domain and prime the chaperone activity.
Timothy O Street, Laura A Lavery, Kliment A Verba, Chung-Tien Lee, Matthias P Mayer

J Mol Biol· January 2012

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Conformational dynamics of the molecular chaperone Hsp90.
Kristin A Krukenberg, Timothy O Street, Laura A Lavery, David A Agard

Q Rev Biophys· May 2011

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Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone.
Timothy O Street, Laura A Lavery, David A Agard

Mol Cell· April 2011

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Osmolyte-induced conformational changes in the Hsp90 molecular chaperone.
Timothy O Street, Kristin A Krukenberg, Jörg Rosgen, D Wayne Bolen, David A Agard

Protein Sci· January 2010

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pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation.
Kristin A Krukenberg, Daniel R Southworth, Timothy O Street, David A Agard

J Mol Biol· July 2009

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Predicting repeat protein folding kinetics from an experimentally determined folding energy landscape.
Timothy O Street, Doug Barrick

Protein Sci· January 2009

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Structures, basins, and energies: a deconstruction of the Protein Coil Library.
Lauren L Perskie, Timothy O Street, George D Rose

Protein Sci· July 2008

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Protein folding and stability using denaturants.
Timothy O Street, Naomi Courtemanche, Doug Barrick

Methods Cell Biol· December 2007

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Physical-chemical determinants of turn conformations in globular proteins.
Timothy O Street, Nicholas C Fitzkee, Lauren L Perskie, George D Rose

Protein Sci· August 2007

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