Publications by authors named "Labeit Siegfried"

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Small-Molecule Targeting MuRF1 Protects Against Denervation-Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms.
Fernando Ribeiro, Paulo R Jannig, Siegfried Labeit, Anselmo S Moriscot

J Cachexia Sarcopenia Muscle· December 2025

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CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress.
Akira Hanashima, Misaki Kimoto, Yoshihiro Ujihara, Ken Hashimoto, Yuu Usui, Siegfried Labeit

Commun Biol· November 2025

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Leucine Supplementation Counteracts the Atrophic Effects of HDAC4 in Rat Skeletal Muscle Submitted to Hindlimb Immobilization.
Paula K N Alves, André Cruz, William J Silva, Afonso M Melazzo, Siegfried Labeit

Muscle Nerve· July 2025

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MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction-Regulating Proteins in a Rat Model of HFpEF.
Beatrice Vahle, Antje Schauer, Antje Augstein, Maria-Elisa Prieto Jarabo, Janet Friedrich, Siegfried Labeit

J Cachexia Sarcopenia Muscle· June 2025

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The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch.
Robbert van der Pijl, Jochen Gohlke, Joshua Strom, Eva Peters, Shengyi Shen, Siegfried Labeit

bioRxiv· June 2025

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Importance of N2BA Titin in Maintaining Cardiac Homeostasis and Its Role in Dilated Cardiomyopathy.
Robbert van der Pijl, Eyad Nusayr, Joshua Strom, Rebecca Slater, Jochen Gohlke, Siegfried Labeit

Circ Heart Fail· March 2025

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Discovery of Titin and Its Role in Heart Function and Disease.
Henk L Granzier, Siegfried Labeit

Circ Res· January 2025

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Small-molecule mediated MuRF1 inhibition protects from doxorubicin-induced cardiac atrophy and contractile dysfunction.
Paula K N Alves, André Cruz, Volker Adams, Anselmo S Moriscot, Siegfried Labeit

Eur J Pharmacol· December 2024

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Modulation of Titin and Contraction-Regulating Proteins in a Rat Model of Heart Failure with Preserved Ejection Fraction: Limb vs. Diaphragmatic Muscle.
Beatrice Vahle, Leonard Heilmann, Antje Schauer, Antje Augstein, Maria-Elisa Prieto Jarabo, Siegfried Labeit

Int J Mol Sci· June 2024

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Class I and II Histone Deacetylase Inhibitors as Therapeutic Modulators of Dilated Cardiac Tissue-Derived Mesenchymal Stem/Stromal Cells.
Rokas Mikšiūnas, Siegfried Labeit, Daiva Bironaite

Int J Mol Sci· June 2024

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Truncated titin is structurally integrated into the human dilated cardiomyopathic sarcomere.
Dalma Kellermayer, Hedvig Tordai, Balázs Kiss, György Török, Dániel M Péter, Siegfried Labeit

J Clin Invest· January 2024

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Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis.
Christos Stergiou, Rhys Williams, Jennifer R Fleming, Vasiliki Zouvelou, Elpinickie Ninou, Siegfried Labeit

Biomedicines· February 2023

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Small-Molecule Inhibition of MuRF1 Prevents Early Disuse-Induced Diaphragmatic Dysfunction and Atrophy.
Fernando Ribeiro, Paula K N Alves, Luiz R G Bechara, Julio C B Ferreira, Siegfried Labeit

Int J Mol Sci· February 2023

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Genetic Ablation of Mitigates Cardiac Damage during Experimental Autoimmune Myocarditis in Mice.
Ieva Rinkūnaitė, Egidijus Šimoliūnas, Milda Alksnė, Gabrielė Bartkutė, Siegfried Labeit

Biomolecules· December 2022

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The Effect of Heat Shock on Myogenic Differentiation of Human Skeletal-Muscle-Derived Mesenchymal Stem/Stromal Cells.
Rokas Mikšiūnas, Siegfried Labeit, Daiva Bironaitė

Cells· October 2022

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The skeletal muscle circadian clock regulates titin splicing through RBM20.
Lance A Riley, Xiping Zhang, Collin M Douglas, Joseph M Mijares, David W Hammers, Siegfried Labeit

Elife· September 2022

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Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model.
Ephraim B Winzer, Antje Schauer, Erik Langner, Antje Augstein, Keita Goto, Siegfried Labeit

Int J Mol Sci· September 2022

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Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits.
Johan Lindqvist, Justin Kolb, Josine de Winter, Paola Tonino, Zaynab Hourani, Siegfried Labeit

Int J Mol Sci· July 2022

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Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility.
Volker Adams, Antje Schauer, Antje Augstein, Virginia Kirchhoff, Runa Draskowski, Siegfried Labeit

J Cachexia Sarcopenia Muscle· June 2022

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miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR.
Paula Ketilly Nascimento Alves, André Cruz, William J Silva, Siegfried Labeit, Anselmo Sigari Moriscot

Int J Mol Sci· June 2022

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MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice.
Kosuke Sugiura, Katsuya Hirasaka, Tasuku Maeda, Takayuki Uchida, Koji Kishimoto, Siegfried Labeit

J Orthop Res· May 2022

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Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium.
Daiva Bironaitė, Ieva Kažukauskienė, Julius Bogomolovas, Dainius Daunoravičius, Artūras Jakubauskas, Siegfried Labeit

Adv Exp Med Biol· May 2022

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Identification of Bovine miRNAs with the Potential to Affect Human Gene Expression.
Moldir Myrzabekova, Siegfried Labeit, Raigul Niyazova, Aigul Akimniyazova, Anatoliy Ivashchenko

Front Genet· January 2022

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Cardiomyogenic Differentiation Potential of Human Dilated Myocardium-Derived Mesenchymal Stem/Stromal Cells: The Impact of HDAC Inhibitor SAHA and Biomimetic Matrices.
Rokas Miksiunas, Ruta Aldonyte, Agne Vailionyte, Tadas Jelinskas, Romuald Eimont, Siegfried Labeit

Int J Mol Sci· November 2021

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Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere.
Julius Bogomolovas, Jennifer R Fleming, Barbara Franke, Bruno Manso, Bernd Simon, Siegfried Labeit

EMBO Rep· October 2021

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