Publications by authors named "Lakshman Segar"

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AICAR promotes endothelium-independent vasorelaxation by activating AMP-activated protein kinase via increased ZMP and decreased ATP/ADP ratio in aortic smooth muscle.
Rajkumar Pyla, Thomas J Hartney, Lakshman Segar

J Basic Clin Physiol Pharmacol· November 2022

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Imatinib improves insulin resistance and inhibits injury-induced neointimal hyperplasia in high fat diet-fed mice.
Prahalathan Pichavaram, Noha M Shawky, Thomas J Hartney, John Y Jun, Lakshman Segar

Eur J Pharmacol· January 2021

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SGLT2 inhibitors and metformin: Dual antihyperglycemic therapy and the risk of metabolic acidosis in type 2 diabetes.
Katherine Donnan, Lakshman Segar

Eur J Pharmacol· March 2019

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Alcohol-induced ketonemia is associated with lowering of blood glucose, downregulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice.
Mukund P Srinivasan, Noha M Shawky, Bhupendra S Kaphalia, Muthusamy Thangaraju, Lakshman Segar

Biochem Pharmacol· February 2019

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Sulforaphane improves leptin responsiveness in high-fat high-sucrose diet-fed obese mice.
Noha M Shawky, Lakshman Segar

Eur J Pharmacol· September 2018

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Pioglitazone Attenuates Injury-Induced Neointima Formation in Mouse Femoral Artery Partially through the Activation of AMP-Activated Protein Kinase.
Islam Osman, Arwa Fairaq, Lakshman Segar

Pharmacology· January 2018

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Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation.
Noha M Shawky, Lakshman Segar

Pharmacol Res· May 2017

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AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia.
Arwa Fairaq, Noha M Shawky, Islam Osman, Prahalathan Pichavaram, Lakshman Segar

Pharmacol Res· May 2017

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High fructose-mediated attenuation of insulin receptor signaling does not affect PDGF-induced proliferative signaling in vascular smooth muscle cells.
Islam Osman, Ninu Poulose, Vadivel Ganapathy, Lakshman Segar

Eur J Pharmacol· November 2016

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Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice.
Noha M Shawky, Prahalathan Pichavaram, George S G Shehatou, Ghada M Suddek, Nariman M Gameil, Lakshman Segar

J Nutr Biochem· June 2016

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Pioglitazone, a PPARγ agonist, attenuates PDGF-induced vascular smooth muscle cell proliferation through AMPK-dependent and AMPK-independent inhibition of mTOR/p70S6K and ERK signaling.
Islam Osman, Lakshman Segar

Biochem Pharmacol· February 2016

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Letter to the Editor: Comment on "SGLT2 inhibitors may predispose to ketoacidosis" by Taylor S.I., et al.
Lakshman Segar

J Clin Endocrinol Metab· February 2016

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Altered energy state reversibly controls smooth muscle contractile function in human saphenous vein during acute hypoxia-reoxygenation: Role of glycogen, AMP-activated protein kinase, and insulin-independent glucose uptake.
Rajkumar Pyla, Prahalathan Pichavaram, Arwa Fairaq, Mary Anne Park, Mark Kozak, Lakshman Segar

Biochem Pharmacol· September 2015

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Vascular protection with dipeptidyl peptidase-IV inhibitors in diabetes: experimental and clinical therapeutics.
Heba A Ahmed, Dianne W May, Susan C Fagan, Lakshman Segar

Pharmacotherapy· March 2015

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Metformin exaggerates phenylephrine-induced AMPK phosphorylation independent of CaMKKβ and attenuates contractile response in endothelium-denuded rat aorta.
Rajkumar Pyla, Islam Osman, Prahalathan Pichavaram, Paul Hansen, Lakshman Segar

Biochem Pharmacol· November 2014

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Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor.
Maha Abdalla, Anna Goc, Lakshman Segar, Payaningal R Somanath

J Biol Chem· November 2013

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Expression of conventional and novel glucose transporters, GLUT1, -9, -10, and -12, in vascular smooth muscle cells.
Rajkumar Pyla, Ninu Poulose, John Y Jun, Lakshman Segar

Am J Physiol Cell Physiol· March 2013

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Leptin treatment inhibits the progression of atherosclerosis by attenuating hypercholesterolemia in type 1 diabetic Ins2(+/Akita):apoE(-/-) mice.
John Y Jun, Zhexi Ma, Rajkumar Pyla, Lakshman Segar

Atherosclerosis· December 2012

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Spontaneously diabetic Ins2(+/Akita):apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis.
John Y Jun, Zhexi Ma, Lakshman Segar

Am J Physiol Endocrinol Metab· July 2011

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PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates.
Yan Zhao, Swarajit K Biswas, Patrick H McNulty, Mark Kozak, John Y Jun, Lakshman Segar

Am J Physiol Cell Physiol· June 2011

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