Publications by authors named "Larry Feldberg"

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Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors.
Christoph M Dehnhardt, Aranapakam M Venkatesan, Zecheng Chen, Efren Delos-Santos, Semiramis Ayral-Kaloustian, Larry Feldberg

Bioorg Med Chem Lett· August 2011

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Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor.
Robert Mallon, Larry R Feldberg, Judy Lucas, Inder Chaudhary, Christoph Dehnhardt

Clin Cancer Res· May 2011

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Synthesis of phosphatidylinositol 3-kinase (PI3K) inhibitory analogues of the sponge meroterpenoid liphagal.
Alban R Pereira, Wendy K Strangman, Frederic Marion, Larry Feldberg, Deborah Roll

J Med Chem· December 2010

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PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor.
Aranapakam M Venkatesan, Zecheng Chen, Osvaldo dos Santos, Christoph Dehnhardt, Efren Delos Santos, Larry Feldberg

Bioorg Med Chem Lett· October 2010

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B-Raf kinase inhibitors: hit enrichment through scaffold hopping.
Ariamala Gopalsamy, Mengxiao Shi, Yongbo Hu, Frederick Lee, Larry Feldberg

Bioorg Med Chem Lett· April 2010

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Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors.
Zecheng Chen, Aranapakam M Venkatesan, Christoph M Dehnhardt, Semiramis Ayral-Kaloustian, Natasja Brooijmans, Larry Feldberg

J Med Chem· April 2010

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Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor.
Robert Mallon, Irwin Hollander, Larry Feldberg, Judy Lucas, Veronica Soloveva

Mol Cancer Ther· April 2010

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Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.
Aranapakam M Venkatesan, Christoph M Dehnhardt, Efren Delos Santos, Zecheng Chen, Osvaldo Dos Santos, Larry Feldberg

J Med Chem· March 2010

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Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.
Aranapakam M Venkatesan, Christoph M Dehnhardt, Zecheng Chen, Efren Delos Santos, Osvaldo Dos Santos, Larry Feldberg

Bioorg Med Chem Lett· January 2010

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Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402.
Christoph M Dehnhardt, Aranapakam M Venkatesan, Efren Delos Santos, Zecheng Chen, Osvaldo Santos, Larry Feldberg

J Med Chem· January 2010

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Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.
Adam M Gilbert, Pawel Nowak, Natasja Brooijmans, Matthew G Bursavich, Christoph Dehnhardt, Larry R Feldberg

Bioorg Med Chem Lett· January 2010

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Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.
Dan M Berger, Nancy Torres, Minu Dutia, Dennis Powell, Greg Ciszewski, Larry Feldberg

Bioorg Med Chem Lett· December 2009

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Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors.
Ariamala Gopalsamy, Greg Ciszewski, Mengxiao Shi, Dan Berger, Yongbo Hu, Larry Feldberg

Bioorg Med Chem Lett· December 2009

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Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens.
David E Williams, Irwin Hollander, Larry Feldberg, Eileen Frommer, Robert Mallon

J Nat Prod· June 2009

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Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors.
Ariamala Gopalsamy, Greg Ciszewski, Yongbo Hu, Frederick Lee, Larry Feldberg

Bioorg Med Chem Lett· May 2009

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4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors.
Dan M Berger, Minu Dutia, Dennis Powell, Middleton B Floyd, Nancy Torres, Larry Feldberg

Bioorg Med Chem· October 2008

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A directly labeled TR-FRET assay for monitoring phosphoinositide-3-kinase activity.
Xiaoke Yang, Puyao Li, Larry Feldberg, Steven C Kim, Michael Bowman

Comb Chem High Throughput Screen· August 2006

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Liphagal, a Selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga: structure elucidation and biomimetic synthesis.
Frederic Marion, David E Williams, Brian O Patrick, Irwin Hollander, Robert Mallon, Larry Feldberg

Org Lett· January 2006

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Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase.
Robert Mallon, Larry Feldberg, Steven Kim, Karen Collins, Donald Wojciechowicz

Mol Cancer Ther· June 2004

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Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade.
Dan Berger, Minu Dutia, Dennis Powell, Biqi Wu, Allan Wissner, Larry R Feldberg

Bioorg Med Chem Lett· September 2003

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Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).
Deniz Tasdemir, Robert Mallon, Michael Greenstein, Larry R Feldberg, Steven C Kim

J Med Chem· January 2002

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