Publications by authors named "Larry Harshyne"

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Extracellular Matrix-MYCAF Signatures Correlate with Resistance to Neoadjuvant aPD-L1 Immune Checkpoint Inhibition with Durvalumab + Metformin in HPV+ HNSCC.
Pablo Llerena, Hani Samarah, Kathryn Nunes, Zhao Lin, Kelly Bridgham, Larry Harshyne

Clin Cancer Res· December 2025

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Neoadjuvant nivolumab plus carboplatin and paclitaxel in patients with locally advanced resectable squamous cell carcinoma of the head and neck: a phase II, single-arm trial.
Ralph G Zinner, Eric V Mastrolonardo, Jennifer M Johnson, Kathryn Nunes, Pablo Llerena, Larry Harshyne

Clin Cancer Res· December 2025

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Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided analysis.
Priyan Bhattacharya, Alban Linnenbach, Andrew P South, Ubaldo Martinez-Outschoorn, Joseph M Curry, Larry A Harshyne

PLoS Comput Biol· June 2025

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Response-Adaptive Surgical Timing in Neoadjuvant Immunotherapy Demonstrates Enhanced Pathologic Treatment Response in Head and Neck Squamous Cell Carcinoma.
Eric V Mastrolonardo, Kathryn L Nunes, Pablo Llerena, Anastasia Nikitina, Anastasia Sobol, Larry A Harshyne

Clin Cancer Res· February 2025

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Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided analysis.
Priyan Bhattacharya, Alban Linnenbach, Andrew P South, Ubaldo Martinez-Outschoorn, Joseph M Curry, Larry A Harshyne

bioRxiv· September 2024

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Predictive capacity of immune-related adverse events and cytokine profiling in neoadjuvant immune checkpoint inhibitor trials for head and neck squamous cell carcinoma.
Angela E Alnemri, Sruti Tekumalla, Annie E Moroco, Ioannis Vathiotis, Madalina Tuluc, Larry A Harshyne

Cancer Med· June 2024

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Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma.
Leonard E Estephan, Gaurav Kumar, Matthew Stewart, Raphael Banoub, Alban Linnenbach, Larry A Harshyne

Front Oncol· June 2024

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IL-8 correlates with nonresponse to neoadjuvant nivolumab in HPV positive HNSCC via a potential extracellular vesicle miR-146a mediated mechanism.
Brianna L Hill, Alyssa N Calder, Joseph P Flemming, Yiyang Guo, Sydney L Gilmore, Larry A Harshyne

Mol Carcinog· September 2023

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CD8+ and FoxP3+ T-Cell Cellular Density and Spatial Distribution After Programmed Death-Ligand 1 Check Point Inhibition.
Joseph Curry, Angela Alnemri, Ramez Philips, Michele Fiorella, Sarah Sussman, Larry Harshyne

Laryngoscope· August 2023

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Nivolumab and ipilimumab in combination with radiotherapy in patients with high-risk locally advanced squamous cell carcinoma of the head and neck.
Jennifer M Johnson, Ioannis A Vathiotis, Larry A Harshyne, Ayesha Ali, Voichita Bar Ad

J Immunother Cancer· August 2023

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Intracellular monitoring by dendritic cells - a new way to stay informed - from a simple scavenger to an active gatherer.
Christopher Herbst, Larry A Harshyne, Botond Z Igyártó

Front Immunol· November 2022

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Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma.
Adam J Luginbuhl, Jennifer M Johnson, Larry A Harshyne, Alban J Linnenbach, Sanket K Shukla

Clin Cancer Res· March 2022

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Cytokine Profiling in Low- and High-Density Small Extracellular Vesicles from Epidermoid Carcinoma Cells.
Joseph P Flemming, Brianna L Hill, Lauren Anderson-Pullinger, Larry A Harshyne, Mỹ G Mahoney

JID Innov· December 2021

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Phase Ib Clinical Trial of IGV-001 for Patients with Newly Diagnosed Glioblastoma.
David W Andrews, Kevin D Judy, Charles B Scott, Samantha Garcia, Larry A Harshyne

Clin Cancer Res· April 2021

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Systemic Immune Bias Delineates Malignant Astrocytoma Survival Cohorts.
Michael Prosniak, Larry A Harshyne, Jonathan Gorky, Mark T Curtis, Lawrence C Kenyon

J Immunol· April 2021

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Discordant Responses Between Primary Head and Neck Tumors and Nodal Metastases Treated With Neoadjuvant Nivolumab: Correlation of Radiographic and Pathologic Treatment Effect.
Dante J Merlino, Jennifer M Johnson, Madalina Tuluc, Stacey Gargano, Robert Stapp, Larry Harshyne

Front Oncol· December 2020

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Cancer-Associated Fibroblast Density, Prognostic Characteristics, and Recurrence in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis.
Alexander M Knops, Andrew South, Ulrich Rodeck, Ubaldo Martinez-Outschoorn, Larry A Harshyne

Front Oncol· November 2020

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miRNA- and cytokine-associated extracellular vesicles mediate squamous cell carcinomas.
Joseph P Flemming, Brianna L Hill, Mohammed W Haque, Jessica Raad, Claudine S Bonder, Larry A Harshyne

J Extracell Vesicles· July 2020

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A Pilot Study of Radiation Therapy in Combination With Pembrolizumab in Patients With Metastatic Renal Cell Cancer.
Jianqing Lin, Andrew J Song, Jean Hoffman-Censits, Benjamin E Leiby, Madalina Tuluc, Larry Harshyne

Am J Clin Oncol· February 2020

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Loss of CD169 Subcapsular Macrophages during Metastatic Spread of Head and Neck Squamous Cell Carcinoma.
Michael C Topf, Larry Harshyne, Madalina Tuluc, Stacey Mardekian, Swar Vimawala

Otolaryngol Head Neck Surg· July 2019

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Prognostic Significance of Tumor-Associated Macrophage Content in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis.
Ayan Tyagi Kumar, Alexander Knops, Brian Swendseid, Ubaldo Martinez-Outschoom, Larry Harshyne

Front Oncol· July 2019

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Potential role of CSF cytokine profiles in discriminating infectious from non-infectious CNS disorders.
Danielle Fortuna, D Craig Hooper, Amity L Roberts, Larry A Harshyne, Michelle Nagurney

PLoS One· April 2019

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Metformin Clinical Trial in HPV+ and HPV- Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate.
Joseph M Curry, Jennifer Johnson, Mehri Mollaee, Patrick Tassone, Dev Amin, Larry Harshyne

Front Oncol· October 2018

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Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.
Huimin Lu, Nicholas Bowler, Larry A Harshyne, D Craig Hooper, Shiv Ram Krishn

Matrix Biol· September 2018

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Macrophage type 2 differentiation in a patient with laryngeal squamous cell carcinoma and metastatic prostate adenocarcinoma to the cervical lymph nodes.
Michael C Topf, Madalina Tuluc, Larry A Harshyne, Adam Luginbuhl

J Immunother Cancer· July 2017

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